Timing and Sequence learning

时间和顺序学习

• 批准号: 6836668
• 负责人: MICHAEL A LONG
• 金额: $ 4.73万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6836668
• 关键词: animal communication behavior; behavioral /social science research tag; electroencephalography; electrostimulus; membrane potentials; neural inhibition; neurogenesis; neurons; neurophysiology; neuropsychology; postdoctoral investigator; psychomotor function; songbirds; synapses; telencephalon; verbal learning; vocalization; voltage /patch clamp

DESCRIPTION (provided by applicant): Despite the fundamental significance of temporal order on brain function, little is known about the circuit mechanisms that underlie the ability to generate and learn sequences. In the songbird premotor pathway, information concerning the production of learned vocalizations is encoded in the spatiotemporal activity patterns within a higher-order nucleus, named HVC. In the present proposal, in vivo intracellular recordings will be used to better understand the mechanisms involved in generating precisely timed sequences of activity within HVC. These experiments will address the role of synaptic inhibition and afferent inputs in generating stereotyped neuronal codes. Furthermore, the ontogeny of sequential activity within HVC will be considered in order to address the means by which learned vocalizations are encoded. The present proposal has direct relevance for human speech learning in that songbirds, unlike most animals such as nonhuman primates, are capable of learning vocalizations.

描述（由申请人提供）：尽管时间顺序对大脑功能具有基本意义，但对产生和学习序列的能力的基础的电路机制知之甚少。在鸣鸟前途径中，有关学习发声的产生的信息在高阶核中的时空活动模式中编码，称为HVC。在本提案中，体内细胞内记录将用于更好地了解HVC内精确定时活性序列所涉及的机制。这些实验将解决突触抑制和传入输入在产生定型神经元代码中的作用。此外，将考虑HVC内顺序活性的个体发育，以解决对学习的声音进行编码的手段。本提案与人类言语学习的直接相关性，因为与大多数非人类灵长类动物等动物不同，该鸣禽能够学习发声。