Drug Reinforcing Effects

药物强化作用

• 批准号: 6769609
• 负责人: RICHARD Alden MEISCH
• 金额: $ 11.72万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6769609
• 关键词: alprazolam; benzodiazepines; drug abuse; drug administration rate /duration; drug interactions; endogenous opioid; laboratory rat; methadone; operant conditionings; psychopharmacology; reinforcer; self medication; substance abuse related behavior

DESCRIPTION: (Provided by Applicant) Four projects are described in this application for a competing renewal of a Research Scientist Award. The first project is a study of the behavioral economics of polydrug abuse: rhesus moneys serve as subjects. Two reinforcing drugs are made concurrently available during daily 3-hr sessions with each drug in a separate reservoir. The objective is to determine how increases in the price of one drug alter intake of both the drugs. Price is determined by the size of the fixed-ratio schedule for the primary drug. The price of the second drug is held constant. If consumption of the second drug increases with increases in price of the primary drug, then the second drug functions as an economic substitute. If consumption of the second drug remains constant then the second drug is an independent commodity, and if consumption of the second drug decreases, then the second drug is an economic complement. The second project is a conceptually similar study that is being conducted in parallel with human subjects. The third project also concerns polydrug abuse, and the design of these studies involves placing a combination of two drugs in a single reservoir, and comparing the relative reinforcing effects of the combination to different concentrations of the constituent. These studies will permit the determination of whether the combination is infra-additive, additive, or supra-additive relative to its constituents. Each of these three projects represents an R01 grant that has been funded. The fourth project concerns studies with rats where the rats' lever pressing is reinforced by experimenter-administered response-contingent injections of drugs of abuse. The injections are delivered SQ. This procedure with rats permits long-term studies that can extend over much of the rats' life span. The studies with rats share with the oral self -administration studies in monkeys the common feature of an experimental preparation that permits studies over long periods of time.

描述：（申请人提供） 在本申请中描述了四个项目，以续签 研究科学家奖。第一个项目是对行为的研究 滥用多毒的经济学：恒河猴是主题。两个加固 每天的每种药物在每天的3小时课程中同时提供药物 在单独的水库中。目的是确定如何增加 两种药物的一种药物改变摄入量的价格。价格由 原发性药物的固定比例时间表的大小。第二个价格 药物保持不变。如果第二种药物的消费随着 初级药物的价格上涨，然后第二种药物用作 经济替代品。如果第二种药物的消耗保持恒定，则 第二种药物是独立商品，如果第二种 药物减少，然后第二种药物是一种经济补充。第二个 项目在概念上类似的研究正在并行进行 与人类主题。第三个项目还涉及滥用多药的项目， 这些研究的设计涉及将两种药物组合在一个 储层，并将组合的相对增强作用与 不同浓度的成分。这些研究将允许 确定该组合是基础添加剂，添加剂还是 相对于其组成部分，超级添加。这三个项目中的每一个 代表已获得资助的R01赠款。第四个项目问题 用大鼠的杠杆压力加强大鼠的研究 实验者管理的反应反应量注射滥用药物。这 注射是SQ。这项与大鼠的过程允许长期研究 这可以延伸到大部分老鼠的寿命上。与大鼠共享的研究 在猴子中的口腔自我管理研究中 实验制备允许长时间的研究。