NOVEL MECHANISMS OF ANTIDEPRESSANT ACTIVITY

抗抑郁活性的新机制

• 批准号: 6724902
• 负责人: JAMES M O'DONNELL
• 金额: $ 13.31万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6724902
• 关键词: adenylate cyclase; antidepressants; behavior; beta adrenergic receptor; dopamine receptor; drug interactions; enzyme activity; isozymes; laboratory rat; microdialysis; neurochemistry; norepinephrine; pharmacokinetics; phosphodiesterase inhibitors; phosphodiesterases; psychopharmacology; receptor expression; transfection

项目成果

Involvement of beta-1 and beta-2 adrenergic receptors in the antidepressant-like effects of centrally administered isoproterenol.

• 发表时间: 1994-10
• 期刊: The Journal of pharmacology and experimental therapeutics
• 作者: J. O'Donnell;S. Frith;J. Wilkins

Clenbuterol increases norepinephrine release from rat brain slices by a calcium- and receptor-independent mechanism.

克仑特罗通过钙和受体独立机制增加大鼠脑片中去甲肾上腺素的释放。

• 发表时间: 1994
• 期刊: Research communications in molecular pathology and pharmacology
• 作者: Murugaiah,KD;O'Donnell,JM
• 通讯作者: O'Donnell,JM