In Vivo Photoactoustic Sensing of Lipid Laden Plaque

脂质斑块的体内光声传感

基本信息

批准号：
9114157
负责人：
Ji-Xin Cheng
金额：
$ 47.82万
依托单位：
PURDUE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-01 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9114157
关键词：
3-Dimensional Acute myocardial infarction Algorithms Angiography Area Arterial Fatty Streak Arteries Arteriogram Arts Atherogenic Diet Atherosclerosis Autopsy Blood Blood Vessels Blood flow Caliber California Cardiovascular system Catheters Chemicals Cholesterol Cholesterol Esters Classification Clinic Clinical Collagen Coronary Coronary Arteriosclerosis Coronary Stenosis Coronary artery Detection Development Devices Diagnosis Doctor of Medicine Esters Family suidae Frequencies Goals Health Histologic Histology Human Image Imagery Imaging Device Imaging Phantoms In Vitro Indiana Inflammation Inflammatory Lasers Lateral Length Life Lipids Measurement Measures Medical Microscopy Modality Modeling Monitor Morphologic artifacts Near-Infrared Spectroscopy Optical Coherence Tomography Optics Patients Performance Physicians Positioning Attribute Procedures Real-Time Systems Research Resolution Roentgen Rays Rotation Rupture Signal Transduction Speed Stenosis Stents Surface Surgeon System Technology Testing Therapeutic Time Tissues Ultrasonic Transducer Ultrasonography Universities base calcification clinically relevant data acquisition design experience feeding imaging system improved in vivo medical schools miniaturize novel photoacoustic imaging radiofrequency sensor spectrograph tool virtual

项目摘要

DESCRIPTION: In current medical treatment of atherosclerosis, a stent is placed for flow-limiting (i.e., >60% stenosis) plaques diagnosed by X-ray based angiography. Revascularization by stenting a flow-limiting coronary artery stenosis has profoundly improved survival. Plaque that is not flow-limiting and thus not stented, however, can be unstable and vulnerable to rupture, which is the major cause of acute myocardial infarction. Currently, no imaging tools exist to diagnose these non-flow-limiting yet potentially vulnerable plaques. The long-term goal of our project is to develop an intravascular vibrational photoacoustic (IVPA) catheter for clinica detection of vulnerable plaques. The objective of this R01 application is to demonstrate an IVPA system for real-time in vivo intravascular visualization of atherosclerotic plaque in a clinically relevant Ossabaw pig model. An interdisciplinary team has been assembled to approach this objective. Dr. Ji-Xin Cheng (Purdue University) is an expert in development and applications of vibrational spectral imaging. Dr. Michael Sturek (Indiana University School of Medicine) is an expert in cardiovascular research. Dr. Qifa Zhou (University of Southern California) is an expert in design and fabrication of ultrasound transducers. Consultant Art Coffey (M.D. in IU Health) is a cardiovascular surgeon who will provide clinical input on the IVPA catheter design. Our central hypothesis is that a high-speed IVPA system allows for in vivo assessment of lipid-rich, inflammatory plaques in an arterial wall. This hypothesis will be tested by 3 Specific Aims. (1) Develop a high-speed IVPA system and demonstrate real-time dual-modality PA/US sensing of an intact atherosclerotic artery in vitro. (2) Differentiate cholesterol crystal (CC) from cholesteol ester (CE)-rich lipid droplets inside an intact artery by spectral analysis of optically induced ultrasound signals. (3) Validate the IVPA system for in vivo assessment of atherosclerotic plaques in an Ossabaw swine model. Successful development of the IVPA system will be able to guide appropriate treatment, e.g. stent deployment, for the lipid-laden, unstable plaque that is not detectable by current intravascular catheters, thus potentially a life-saving technology.

描述：在当前的动脉粥样硬化治疗中，通过基于 X 射线的血管造影诊断出血流限制（即 >60% 狭窄）斑块，通过在血流限制性冠状动脉狭窄处植入支架进行血运重建可显着提高患者的生存率。然而，它不是流量限制的，因此没有支架，可能不稳定并且容易破裂，这是急性心肌梗塞的主要原因目前，还没有成像工具可以诊断这些非血流限制但可能易损的斑块，我们项目的长期目标是开发一种用于临床检测易损斑块的血管内振动光声（IVPA）导管。该 R01 应用旨在展示一种 IVPA 系统，可在临床相关的 Ossabaw 猪模型中实时显示血管内动脉粥样硬化斑块，以实现这一目标。 Ji-Xin Cheng（普渡大学）是振动光谱成像开发和应用方面的专家。Michael Sturek 博士（印第安纳大学医学院）是心血管研究方面的专家。 Qifa Zhou 博士（南加州大学）是一位心血管研究专家。超声换能器设计和制造专家 Art Coffey（印第安纳大学健康医学博士）是一位心血管外科医生，他将为 IVPA 导管设计提供临床意见。该系统可对动脉壁中富含脂质的炎症斑块进行体内评估，该假设将通过 3 个具体目标进行测试 (1) 开发高速 IVPA 系统并演示实时双模态 PA/US 传感。 (2) 通过光诱导超声信号的光谱分析将胆固醇晶体 (CC) 与完整动脉内富含胆固醇酯 (CE) 的脂滴区分开来。验证 IVPA 系统用于 Ossabaw 猪模型中动脉粥样硬化斑块的体内评估 IVPA 系统的成功开发将能够指导适当的治疗，例如针对富含脂质的不稳定斑块。目前的血管内导管无法检测到，因此可能是一种挽救生命的技术。