IGF::OT::IGF Recipient Epidemiology and Donor Evaluation Study III (REDS-III) - International Sites - Phase 3

IGF::OT::IGF 受者流行病学和捐助者评估研究 III (REDS-III) - 国际站点 - 第 3 阶段

• 批准号: 9581241
• 负责人: DARYL CARSON
• 金额: $ 70.88万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9581241
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adult; Affect; Alloimmunization; Amendment; Area; Basic Science; Behavior; Biological; Biological Sciences; Blood; Blood Banks; Blood Donations; Blood Transfusion; Blood donor; Blood donor screening; Books; Budgets; Catalogs; Characteristics; Clinical Research; Clinical Sciences; Code; Collaborations; Collection; Contractor; Contracts; Country; Data; Data Collection; Data Coordinating Center; Data Element; Data Set; Databases; Development; Education; Educational Activities; Ensure; Epidemic; Epidemiology; Evaluation Studies; Geography; Goals; Government; HIV; HIV-1; HIV-2; Health Insurance Portability and Accountability Act; Health Personnel; Incidence; Income; Infection; Infectious Agent; Informed Consent; Institution; Institutional Review Boards; International; Knowledge; Laboratories; Laboratory Study; Language; Leadership; Location; Manuals; Medical; Medicine; Methodology; Monitor; National Heart, Lung, and Blood Institute; Office Management; Participant; Pathologic; Patient Care; Patient Education; Performance; Phase; Policy Developments; Prevalence; Principal Investigator; Procedures; Process; Protocols documentation; Public Health; Publications; Questionnaires; Reporting; Research; Research Activity; Research Methodology; Research Personnel; Risk; Risk Factors; Safety; Sampling; Ships; Site; Specimen; Surveys; Technical Expertise; Test Result; Testing; Training; Training and Education; Transfusion; Translating; Translational Research; Vascular blood supply; Writing; base; epidemiology study; evidence base; evidence based guidelines; improved; interest; meetings; member; operation; population based; prevent; programs; repository; research study; response; sample collection; symposium; transmission process; work-study

The objectives of the REDS-III program are to ensure safe and effective blood banking and transfusion medicine practices through a comprehensive, multi-targeted strategy involving basic, translational, and clinical research to improve the benefits of transfusion while reducing its risks. Improving blood component safety and availability in the U.S. and internationally through the conduct of epidemiologic, survey, and laboratory studies is the cornerstone of the REDS program. Transfusion therapy is the most commonly employed, and, arguably, one of the least understood medical procedures in the U.S. affecting about five million recipients annually. This research program is not only critical to public health in the U.S. but also to countries struggling with the HIV epidemic where blood safety and availability are major concerns. The REDS-III program is comprised of one Data Coordinating Center (DCC), one Central Laboratory, four domestic hubs, and three international collaborative programs involving U.S. investigators and investigators at international blood centers. The REDS-III program will target the following blood banking and transfusion medicine areas: donor targeted strategies; blood banking; transfusion practices in adult patients; and education and training. The goal of the International program is to address scientific questions to improve the safety and adequacy of the blood supply in selected low or middle income countries affected by the HIV/AIDS epidemic. The REDS-III international sites shall conduct epidemiologic, laboratory, and survey research primarily on blood donors with a major research focus on reducing and preventing the transmission of HIV/AIDS and other known and emerging infectious agents through transfusion. Studies in transfusion recipients may also be conducted. The major objectives of the research in the international program are: 1) assess and monitor the prevalence and incidence of HIV-1, HIV-2 and other existing as well as newly discovered infectious agents that pose a threat to blood safety; 2) assess risks of transfusion-transmitted infections; 3) assess the impact of existing and new blood donor screening methodologies on blood safety and availability; 4) evaluate characteristics and behaviors of blood donors including risk factors for acquiring HIV and other blood-borne agents; and 5) evaluate the donation process for ways to improve the safety and adequacy of the blood supply. Some studies may also address transfusion recipient safety concerns such as evaluating non-infectious transfusion risks (e.g., alloimmunization) and ways to reduce their occurrence.

REDS-III 计划的目标是通过涉及基础、转化和临床研究的全面、多目标策略，确保安全有效的血库和输血医学实践，以提高输血的益处，同时降低其风险。通过流行病学、调查和实验室研究来提高美国和国际上血液成分的安全性和可用性是 REDS 计划的基石。输血疗法是最常用的治疗方法，也可以说是美国最不为人所知的医疗程序之一，每年影响约 500 万接受者。该研究计划不仅对美国的公共卫生至关重要，而且对那些与艾滋病毒流行作斗争的国家也至关重要，因为血液安全和供应是这些国家的主要关注点。 REDS-III 项目由 1 个数据协调中心 (DCC)、1 个中心实验室、4 个国内中心以及 3 个涉及美国研究人员和国际血液中心研究人员的国际合作项目组成。 REDS-III 计划将针对以下血库和输血医学领域：针对捐助者的策略；血库；成年患者的输血实践；以及教育和培训。该国际计划的目标是解决科学问题，以改善受艾滋病毒/艾滋病影响的选定低收入或中等收入国家的血液供应的安全性和充足性。 REDS-III 国际站点应主要针对献血者进行流行病学、实验室和调查研究，主要研究重点是减少和预防通过输血传播艾滋病毒/艾滋病和其他已知和新出现的传染源。还可以对输血接受者进行研究。 该国际计划研究的主要目标是： 1) 评估和监测 HIV-1、HIV-2 和其他现有的以及新发现的对血液安全构成威胁的传染源的流行率和发病率； 2）评估输血传播感染的风险； 3) 评估现有和新的献血者筛查方法对血液安全性和可用性的影响； 4) 评估献血者的特征和行为，包括感染艾滋病毒和其他血源性病原体的危险因素； 5) 评估献血过程，寻找提高血液供应安全性和充足性的方法。一些研究还可能解决输血接受者的安全问题，例如评估非传染性输血风险（例如同种免疫）以及减少其发生的方法。