Use of Diffuse Optical Tomography for Stroke Management

使用漫射光学断层扫描进行中风管理

基本信息

  • 批准号:
    6833700
  • 负责人:
  • 金额:
    $ 48.22万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2003
  • 资助国家:
    美国
  • 起止时间:
    2003-03-15 至 2006-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Stroke is the third leading cause of death in the United States and the leading cause of disability among adults. Currently, there are roughly 4 million stroke survivors with some sort of neurological impairment with $43 billion each year in health care costs and lost productivity. The main goal of this Phase II proposal is to develop, build and test a portable and non-invasive diffuse optical tomography (DOT) system for functional brain oxygenation monitoring. The objective of the innovation is to allow for continuous wave, real time measuring of cerebral hemodynamic activity associated with brain function, and to apply it to the study and clinical management of functional recovery in stroke survivors. This innovation promises the delivery of new technology for helping to improve in the diagnosis, treatment and care of stroke patients. In this program our Aims are to (1) develop DSP hardware modules with firmware; Aim (2) develop software capable of providing and visually displaying recordings in real time from 32 lasers and 32 detectors, generating 1024 single channels (i.e., with a 10 ms temporal resolution); Aim (3) conduct test verification in phantoms and in clinical studies of stroke patients. The test experiments will help to determine the extent of brain damage in stroke patients and to evaluate the benefits of exercise in the motor cortex. With continued funding, this Phase II enhances the value of other funded studies by NIH and for the general scientific community, who benefit from the advancement of non-invasive technology for other brain monitoring applications, such as epilepsy, dyslexia and head trauma. The continued funding and development will enable increased sales and commercialization for an improved portable, non-invasive brain-monitoring device. The long-term value for stroke patients is a medical device that provides continuous brain monitoring during treatment at the bedside in the hospitals and for therapy in rehabilitation centers and in-home. The long-term value for the health care community is improved quality of care at lower costs and less suffering.
描述(由申请人提供):中风是美国第三大死亡原因,也是成年人中残疾的主要原因。目前,大约有400万个中风幸存者,每年的医疗保健费用为430亿美元,生产力降低了。该II期建议的主要目标是开发,建立和测试用于功能性脑充氧监测的便携式和非侵入性弥漫性光学层析成像(DOT)系统。创新的目的是允许连续波,与脑功能相关的脑血液动力学活性的实时测量,并将其应用于中风幸存者功能恢复的研究和临床管理。这项创新有望提供新技术,以帮助改善中风患者的诊断,治疗和护理。在此程序中,我们的目的是(1)使用固件开发DSP硬件模块; AIM(2)开发能够从32个激光器和32个检测器实时提供和视觉上显示录音的软件,生成1024个单个通道(即具有10 ms的时间分辨率);目标(3)在幻影和中风患者的临床研究中进行测试验证。测试实验将有助于确定中风患者的脑损伤程度,并评估运动皮层运动中运动的好处。通过持续的资金,这一第二阶段增强了NIH和通用科学界的其他资助研究的价值,他们从非侵入性技术的进步中受益于其他大脑监测应用,例如癫痫,阅读障碍和头部创伤。持续的资金和开发将使销售和商业化增加,以改善便携式,非侵入性的大脑监测装置。中风患者的长期价值是一种医疗装置,可在医院的床边进行连续的大脑监测以及在康复中心和家中进行治疗。卫生保健社区的长期价值是提高了护理质量,成本较低,苦难减少。

项目成果

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WILLIAM A JOHNSON其他文献

WILLIAM A JOHNSON的其他文献

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{{ truncateString('WILLIAM A JOHNSON', 18)}}的其他基金

Use of Diffuse Optical Tomography for Stroke Management
使用漫射光学断层扫描进行中风管理
  • 批准号:
    6551783
  • 财政年份:
    2003
  • 资助金额:
    $ 48.22万
  • 项目类别:
EEG Data Monitoring System Used in Conjunction with fMRI
脑电图数据监测系统与功能磁共振成像结合使用
  • 批准号:
    6585309
  • 财政年份:
    2003
  • 资助金额:
    $ 48.22万
  • 项目类别:
Use of Diffuse Optical Tomography for Stroke Management
使用漫射光学断层扫描进行中风管理
  • 批准号:
    6949666
  • 财政年份:
    2003
  • 资助金额:
    $ 48.22万
  • 项目类别:

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