Novel laser-processed scintillation detector for high-resolution PET scanners

用于高分辨率 PET 扫描仪的新型激光加工闪烁探测器

基本信息

批准号：
9197984
负责人：
Hamid Sabet
金额：
$ 21.77万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-12-21 至 2018-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9197984
关键词：
Address Animal Model Animals Behavior Biochemical Process Biological Markers Collection Computer Simulation Crystallization Data Development Diamond Elements Gamma Rays Goals Image Imagery Knowledge Lasers Lateral Light Location Magnetic Resonance Imaging Measurement Mechanical Stress Mechanics Methods Modality Modeling Modernization Nature Optics Organism Output Pattern Performance Pharmacologic Substance Physics Physiological Processes Polishes Positron-Emission Tomography Price Process Property Refractive Indices Research Research Project Grants Research Proposals Resolution Shapes Side Structure Surface System Techniques Technology Thick Time Work base cost cost effective density design detector driving force human disease imaging study imaging system improved indexing molecular imaging novel pre-clinical process optimization public health relevance thermal stress

项目摘要

DESCRIPTION (provided by applicant): Small animal PET studies are crucial in development of new pharmaceuticals and therapies as well as quantification of diverse biochemical and physiological processes in living organism. Visualized and quantified imaging of structures in small animals, however, imposes stringent requirements on the imaging system. Satisfying these requirements simultaneously necessitates expensive approaches and typically results in trading off between key performance metrics such as spatial resolution and sensitivity. The scintillators used in the majority of the modern PET systems and those under development are high density orthosilicate-based materials such as LYSO, LSO, LGSO, and GSO thanks to their high stopping power, fast decay time, non- hygroscopic nature, and relatively high light output. These scintillators are mechanically pixelated to form an array of scintillator elements to achieve high spatial resolution. However, array fabrication with pixels that have small cross-section (e.g. 1x1 mm2) and large thickness (e.g. 15 mm) is challenging and expensive which leads to a number of issues such as light collection problem, practical difficulties of accurate and consistent crystal size, and high cost associated with fine crystal cutting and surface treatment (polishing). In the mechanically pixelated arrays, a reflecting material is inserted between the pixels which leads to low packing fraction and thereby loss of sensitivity to gamma rays. Our goal is develop a PET detector using recently emerged technology called Laser-Induced Optical barriers (LIOB) in that we create optical barriers within the scintillation detector to control the light spread function and hence the spatial resolution. The significance of this research work is that using LIOB, development of high sensitivity PET detectors with sub-millimeter intrinsic spatial and DOI capability is achievable in a very cost effective manner. Our specific aims are to 1) Simulate the properties of laser induced optical barriers and correlate the results with experimental data. 2) Model a laser processed detector and optimize the optical barriers pattern, and 3) Fabricate and characterize LYSO detectors processed by LIOB technique.

描述（由申请人提供）：小动物 PET 研究对于开发新药物和疗法以及定量活体生物体中的各种生化和生理过程至关重要，然而，对小动物结构的可视化和量化成像提出了严格的要求。同时满足这些要求需要昂贵的方法，并且通常会导致在大多数现代 PET 系统中使用的闪烁体和敏感度等关键性能指标之间进行权衡。正在开发的高密度原硅酸盐材料，如 LYSO、LSO、LGSO 和 GSO，得益于它们的高阻止能力、快速衰减时间、非吸湿性和相对高的光输出。这些闪烁体通过机械像素化形成阵列。闪烁体元件实现然而，具有小横截面的像素阵列制造（例如 1x1 mm2）和大厚度（例如15毫米）具有挑战性且昂贵，这会导致许多问题，例如光收集问题、精确一致的晶体尺寸的实际困难以及与精细晶体切割和表面处理（抛光）相关的高成本在机械像素化阵列中，在像素之间插入反射材料，这会导致堆积率降低，从而降低对伽马射线的灵敏度。激光诱导光学屏障 (LIOB)，我们在闪烁探测器内创建光学屏障来控制这项研究工作的意义在于，使用 LIOB，可以以非常经济有效的方式开发具有亚毫米固有空间和 DOI 功能的高灵敏度 PET 探测器。 ) 模拟激光诱导光学屏障的特性，并将结果与实验数据关联起来 2) 模拟激光加工的探测器并优化光学屏障图案，以及 3) 制造并表征通过 LIOB 技术加工的 LYSO 探测器。