Statistical methods for estimating relative intensity physical activity and its association with cardiometabolic disease
估计相对强度体力活动及其与心脏代谢疾病关联的统计方法
基本信息
- 批准号:9235966
- 负责人:
- 金额:$ 16.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-12-15 至 2018-11-30
- 项目状态:已结题
- 来源:
- 关键词:AccelerometerAccountingAddressAdultAerobicAfrican AmericanAgeCalciumCalibrationCationsClinical ResearchCohort StudiesCoronary Artery Risk Development in Young Adults StudyCoronary arteryDataDevelopmentDevicesDiabetes MellitusDiseaseDoseElderlyEnergy MetabolismExerciseExertionGoalsGuidelinesHealthHeart RateHigh Density Lipoprotein CholesterolHypertensionIndividualMeasurementMeasuresMethodologyMethodsModelingMonitorMovementObesityObservational StudyOutcomeParticipantPersonsPhysical activityPhysiciansPhysiologicalPublishingRecommendationResearchRiskRisk FactorsStandardizationStatistical MethodsTreadmill TestsTriglyceridesUnited States Dept. of Health and Human ServicesUpdateValidationWomanWorkagedbasecardiovascular disorder riskdeconditioningdesignepidemiology studyexercise capacityexercise intensityexercise interventionfitnessmenmiddle agenovelphysical conditioningprospectiveresearch studyresponsesedentaryvigorous intensitywaist circumferenceyoung adult
项目摘要
PROJECT SUMMARY
Intensity is a key factor when considering the dose of physical activity (PA) required to achieve specific health
and fitness outcomes. The intensity of aerobic PA can be defined either in terms of absolute intensity or
relative intensity. Absolute intensity refers to the energy or work required to perform an activity and does not
take into account the exercise capacity of the individual. Relative intensity takes into account or adjusts for a
person's exercise capacity. For many obese and/or unfit adults, it may not be possible to achieve moderate-
intensity PA as measured on an absolute scale due to their low exercise capacity. However, these adults may
be able to perform moderate-intensity PA on a relative scale. There is limited evidence regarding the dose of
relative intensity PA necessary to promote and maintain health. Addressing this question has important
implications regarding how individuals should monitor their PA intensity, how physicians should prescribe PA,
and how exercise interventions should be designed. One reason for the limited amount of evidence on the
relationship between relative intensity PA and health is the fact that it is difficult to measure relative intensity.
As a result, nearly all large prospective observational studies measure PA intensity on an absolute scale.
Wearable monitors (accelerometers) are widely used in both epidemiological and clinical research studies for
capturing objective estimates of PA without a large participant burden. These devices convert body movement
into derived accelerometer “counts” and there are several published thresholds or cut-points for classifying PA
intensity on an absolute scale based on counts. The Coronary Artery Risk Development in Young Adults
(CARDIA) study is an ongoing cohort study of 5,115 African American and White men and women aged 18-30
at baseline in 1985-1986. In 2005-2006, an ancillary CARDIA Fitness Study was performed on 2,760
participants aged 38 to 50 who wore accelerometers during a standardized graded exercise treadmill test and
for 1 week of normal activity. Participants were subsequently re-examined in 2010-2011 and 2015-2016 to
measure the development of cardiovascular disease risk factors. Using data from the CARDIA study, we will
develop and validate statistical methods for objectively measuring relative intensity PA using accelerometry.
Our specific aims are: 1) Develop statistical methods for calculating relative-intensity PA accelerometer cut-
points and apply these methods to data from the CARDIA exercise treadmill test; 2) Use the CARDIA data to
estimate the relationship between relative-intensity PA and the development of cardiometabolic disease as
compared to absolute-intensity PA. 3) Investigate the generalizability of our methodology to more translational
calibration settings.
项目概要
在考虑实现特定健康所需的体力活动 (PA) 剂量时,强度是一个关键因素
有氧运动强度可以用绝对强度或健身结果来定义。
相对强度。绝对强度是指执行某项活动所需的能量或功,而不是能量或功。
考虑个人的运动能力 考虑或调整相对强度。
对于许多肥胖和/或不健康的成年人来说,可能无法达到中等水平。
由于运动能力低,这些成年人可能会以绝对量表测量强度 PA。
能够在相对范围内进行中等强度的 PA 关于剂量的证据有限。
促进和维持健康所需的相对强度 PA 具有重要意义。
关于个人应如何监测其 PA 强度、医生应如何开 PA 处方的影响,
以及如何设计运动干预措施的原因之一是证据数量有限。
PA相对强度与健康的关系在于相对强度难以测量。
因此,几乎所有大型前瞻性观察研究都以绝对尺度测量 PA 强度。
可穿戴监测器(加速度计)广泛应用于流行病学和临床研究中
这些设备可以在不增加参与者负担的情况下捕获 PA 的客观估计。
转化为派生的加速度计“计数”,并且有几个已发布的 PA 分类阈值或切点
基于计数的绝对范围的强度。
(CARDIA) 研究是一项持续进行的队列研究,对象为 5,115 名 18-30 岁的非裔美国人和白人男性和女性
1985-1986 年基线 2005-2006 年,对 2,760 人进行了辅助 CARDIA 健康研究。
38 至 50 岁的参与者在标准化分级运动跑步机测试中佩戴加速计,
随后在 2010-2011 年和 2015-2016 年对参与者进行了 1 周的正常活动检查。
我们将使用 CARDIA 研究的数据来衡量心血管疾病危险因素的发展。
开发并验证使用加速度计客观相对测量强度 PA 的统计方法。
我们的具体目标是: 1) 开发计算相对强度 PA 加速度计切割的统计方法
点并将这些方法应用于 CARDIA 运动跑步机测试的数据 2) 使用 CARDIA 数据
估计相对强度 PA 与心脏代谢疾病发展之间的关系为
与绝对强度 PA 相比 3) 研究我们的方法对更多转化的通用性。
校准设置。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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