Noise, Solvents, and Hearing Loss

噪音、溶剂和听力损失

• 批准号: 6667340
• 负责人: PETER MACGARR RABINOWITZ
• 金额: $ 29.34万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2005-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6667340
• 关键词: clinical research; disease /disorder proneness /risk; environmental exposure; epidemiology; hearing disorders; human data; longitudinal human study; noise; noise induced deafness; occupational hazard; occupational health /safety; solvents

DESCRIPTION (provided by applicant): While noise, one of the most prevalent occupational hazards, is well recognized as a cause of high frequency hearing loss, a growing body of evidence suggests that organic solvents, also widespread in industry, may also increase the risk of hearing loss. There is a need for longitudinal studies of exposed workers to further investigate this possibility. Determining a dose-response relationship for solvents and hearing loss could affect further efforts to control exposures and prevent hearing loss. This study will make use of the Alcoa database, a unique longitudinal set of a large working population which includes a significant number of women and African Americans. This data set contains both detailed exposure information regarding noise and solvents as well as hearing tests on employees in U.S. Alcoa facilities. Preliminary study of this database reveals that noise hearing loss is a significant problem, and that a significant number of workers are exposed to solvents. The long term goal of the study is to examine effects of chronic solvent exposure on hearing, as well as the impact of noise-solvent interactions on the auditory system. The study will investigate these effects through a longitudinal cohort study of 8800 worjers hired at Alcoa between 1983 and 1997. This would be the largest study to date of noise, solvents, and hearing, and will allow for calculation of relative risks of developing hearing lost for solvent and noise exposed workers. Modeling of industrial hygiene sampling data will allow for cumulative estimates of noise and solvent exposures. A nested case control study will match cases of hearing loss identified in the cohort with controls by age at hire, year of hire, sex, and gender, to further explore these relationships.

描述（由申请人提供）：虽然噪音是最普遍的职业危害之一，被公认为是导致高频听力损失的原因，但越来越多的证据表明，工业中广泛使用的有机溶剂也可能增加风险听力损失。 有必要对暴露工人进行纵向研究，以进一步调查这种可能性。 确定溶剂和听力损失的剂量反应关系可能会影响控制暴露和预防听力损失的进一步努力。 这项研究将利用美国铝业数据库，这是一个独特的大型工作人口纵向数据集，其中包括大量女性和非裔美国人。 该数据集包含有关噪音和溶剂的详细暴露信息以及美国铝业工厂员工的听力测试。 该数据库的初步研究表明，噪音听力损失是一个严重的问题，并且大量工人接触溶剂。 该研究的长期目标是检查长期接触溶剂对听力的影响，以及噪声与溶剂相互作用对听觉系统的影响。 该研究将通过对 1983 年至 1997 年间美国铝业公司雇用的 8800 名工人进行纵向队列研究来调查这些影响。这将是迄今为止关于噪音、溶剂和听力的最大研究，并将允许计算听力损失的相对风险适用于接触溶剂和噪音的工人。 工业卫生采样数据的建模将允许对噪声和溶剂暴露进行累积估计。 嵌套病例对照研究将队列中发现的听力损失病例与按雇用年龄、雇用年份、性别和性别进行对照的病例进行匹配，以进一步探讨这些关系。