SELECTIVE REMOVAL OF EXTRAOCULAR MUSCLE

选择性去除眼外肌

• 批准号: 6555187
• 负责人: ALAN B SCOTT
• 金额: $ 10.63万
• 依托单位: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6555187
• 关键词: Primates; denervation; extraocular muscle; eye coordination disorder; eye laser surgery; eye movements; eye surgery; laboratory rabbit; microsurgery; muscle function; nonhuman therapy evaluation; postoperative state; saccades; smooth pursuit eye movement; technology /technique development; Primates; denervation; extraocular muscle; eye coordination disorder; eye laser surgery; eye movements; eye surgery; laboratory rabbit; microsurgery; muscle function; nonhuman therapy evaluation; postoperative state; saccades; smooth pursuit eye movement; technology /technique development

DESCRIPTION: Aim 1 defines the microsurgical anatomy of human extraocular muscle that is needed for erbium laser procedure development. Aim 2 represents a design/development phase in adapting a commercial erbium laser for the purpose of selective weakening of extraocular muscle. Aims 3 and 4 use a rabbit model to develop laser applications specific for the targeted removal of a longitudinal muscle strip and denervation of selected segments of extraocular muscle. Aim 5 applies the targeted muscle compromise procedures developed in the rabbit to a subhuman primate model in which both muscle morphology and quantitative eye movement behavior can be tightly correlated. Aim 6 represents human pilot studies needed for design of clinical trials for the therapy developed in this proposal.

描述：AIM 1定义人外生眼的显微外科解剖结构 ERBIUM激光程序开发所需的肌肉。 目标2 代表适应商业元素的设计/开发阶段 激光是为了选择性削弱眼外肌肉的目的。 目标 3和4使用兔模型开发特有的激光应用 有针对性的去除纵向肌肉条和去神经 选定的眼外肌肉段。 AIM 5应用目标 在兔子向亚人类灵长类动物开发的肌肉妥协程序 肌肉形态和定量眼运动的模型 行为可以紧密相关。 AIM 6代表人类飞行员研究 为此开发的临床试验设计需要设计 提议。