VISUAL-MOTOR TRANSFORMATIONS IN PARIETAL CORTEX

顶叶皮层的视觉运动转换

• 批准号: 6498322
• 负责人: Lawrence H Snyder
• 金额: $ 23.67万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6498322
• 关键词: Primates; arm; behavior test; body movement; brain mapping; eye movements; head movements; limb movement; neural information processing; parietal lobe /cortex; sensorimotor system; space perception; visual stimulus

DESCRIPTION (Adapted From The Applicant's Abstract): This proposal will investigate the role of the posterior parietal cortex in directing movements to visible targets. The parietal cortex clearly plays a role in this process, but the nature of that role is unresolved. Complicating the issue is the fact that parietal cortex contains multiple fields, many of which are involved in the processing of visual spatial information, and some of which appear to be related to the movements of particular body parts. A common approach to studying the role of these fields in transforming sensory information into motor commands has been to consider the frame of reference of the spatial information that each contains. The PI now proposes to study, in addition, whether and how the information is specifically related to arm, eye and head movements (motor specificity). The development of motor specific responses relates to the selection of a particular motor response, a critical stage in the sensory to motor transformation. It is suggested that response selection and reference frame transformation are two distinct and potentially separable components of that transformation. This approach is a significant departure from previous work, which has typically considered only a single motor output. Aim I will characterize the exact relationship between motor specificity and frame of reference for activity in the ventral intraparietal area (VIP). The experiments and their analysis are designed to capture the full range and potential richness of the properties of individual neurons, rather than merely categorizing them as "motor" or "sensory." Aim 2 will examine motor-specific activity in the lateral intraparietal area (LIP) and in the parietal reach region (PRR). We will determine how signals encoding the decision to take one course of action or another interact with signals encoding spatial information. Finally, Aim 3 will challenge an established hypothesis concerning spatial information processing in LIP. The hypothesis has important ramifications for whether processing may be directed towards specific motor outputs. Taken together, the results of these aims are likely to provide new insight into the role of parietal cortex in the sensory to motor transformation in general, and in particular, into the role of specific fields in directing eye, arm and head movements to visual targets.

描述（根据申请人的摘要改编）：该提案将 研究后顶叶皮层在引导运动中的作用 可见目标。顶叶皮质显然在此过程中起作用，但 该角色的性质尚未解决。使问题复杂化的事实是 顶叶皮质包含多个字段，其中许多涉及 视觉空间信息的处理，其中一些似乎是 与特定身体部位的运动有关。一种常见的方法 研究这些领域在将感官信息转换为 电机命令是考虑空间的参考框架 每个包含的信息。 PI现在建议研究 信息是否以及如何与手臂，眼睛和头部特别相关 运动（运动特异性）。电机特定响应的发展 与选择特定电机响应的选择有关，这是一个关键阶段 运动转化的感觉。建议选择响应 和参考框架转换是两个不同的，可能可分开的 该转换的组成部分。这种方法是一个重大的离开 从以前的工作中，通常仅考虑一个电动机输出。 目的我将表征运动特异性与 腹侧室内区域（VIP）活动活动的参考框架。这 实验及其分析旨在捕获整个范围， 单个神经元的性质的潜在丰富性，而不是仅仅 将它们归类为“电机”或“感觉”。 AIM 2将检查特定电动机 侧面室内区域（唇）和顶距离的活动 区域（PRR）。我们将确定如何编码决定的信号 行动课程或另一个与编码空间信息的信号相互作用。 最后，AIM 3将挑战有关空间的既定假设 嘴唇中的信息处理。该假设对 处理是否可以针对特定的电动机输出。拍摄 总之，这些目标的结果可能会提供有关该目标的新见解 顶叶皮层在运动转化的感觉中的作用，并且 特别是，特定领域在指导眼，手臂和头部的作用 移动到视觉目标。