THE AUSTRALIAN BREAST CANCER FAMILY REGISTRY

澳大利亚乳腺癌家族登记处

• 批准号: 6650866
• 负责人: JOHN L HOPPER
• 金额: $ 62.67万
• 依托单位: UNIVERSITY OF MELBOURNE
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2005-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6650866
• 关键词: Australia; breast neoplasms; cancer registry /resource; cooperative study; family genetics; neoplasm /cancer genetics

The broad aim of this grant is to expand the material collected by the Australian Breast Cancer Family Study (ABCFS) between 1996 and 2000 on 1,5000 families as part of the CFRBCS, in terms of pathology, biospecimens, clinical data and epidemiology. The specific aims are for this resource to contribute to the 13 Scientific Modules of this competitive UO1 grant application. This includes a 5 year Systematic Follow-up Study of all 20,000 consenting individuals (8,000 affected) recruited into the CFBRCS, so as to form a prospective cohort study for cancer families. It also includes a study of cases and 750 controls in both Australia and Canada, and replication of positive findings sought by within-family analyses of population-based resources from those two sites, and from Northern California. These two modules are included in this application. It is proposed that an Australian Breast Cancer Family Registry (ABCFR) be created by combining the above material with data collected in 1992- 1995 by the ABCFS on 466 case and 408 control families by the ABCFS using local funds, and by adding a new consortium, the Kathleen Cunningham Foundation Consortium for Research in Familial Breast Cancer (KconFab), also locally funded. Funding is sought for follow-up of an anticipated 400 families, and for testing for mutations in BRCA1 and BRCA2 in 500 KconFab families. As well as being coordinators on the two modules above, the PIs of the ABCFS have a major role on other modules, including the Prognosis and Pathology Characteristics of Heritable Breast Cancer, Estrogen Gene Variants and Breast Cancer, Penetrance and Prevalence of BRCA1/BRCA2 Mutations in the CFRBCS and Identification of Novel Genes Involved in Breast Cancer Susceptibility. Funding is sought for the contribution to these and other modules of data, DNA and administration of questionnaires. This Australian Registry will make a major contribution to the CFRBC's efforts to elucidate the genetic and environmental causes of breast cancer, and translate this into benefits for women at risk of, or affected by, breast cancer.

这笔赠款的广泛目的是将澳大利亚乳腺癌家族研究（ABCFS）收集的材料扩展到1996年至2000年之间，以1,5000个家庭作为CFRBC的一部分，就病理学，生物测量，临床数据和流行病学而言。具体的目的是使该资源有助于该竞争性UO1赠款应用程序的13个科学模块。这包括对所有20,000名同意个人（受影响的8,000名）进行5年系统的随访研究，以形成针对癌症家庭的前瞻性队列研究。它还包括对澳大利亚和加拿大的病例和750个控制的研究，以及复制来自这两个地点以及北加州的基于人群资源的家庭内部分析所寻求的积极发现。这两个模块包含在此应用程序中。建议通过将上述材料与ABCFS于1992年至1995年收集的数据相结合的澳大利亚乳腺癌家庭注册表（ABCFR），并使用当地资金将ABCF的408个案例和408个控制家庭组合在一起，并增加了一个新的联盟，并添加了一个新的联盟，即Kathleen Cunningham Contortial in Commial Breastical Cancer concconfab）（Kathleen Cunningham Foundate in Kathleenham Concconfife）（KATHLEENHAM）基金会（Kathleenham）。寻求资金来跟进预期的400个家庭，并在500 kconfab家庭中测试BRCA1和BRCA2的突变。除了上述两个模块上的协调员外，ABCF的PI还在其他模块中发挥了重要作用，包括可遗传性乳腺癌的预后和病理特征，雌激素基因变异和乳腺癌，BRCA1/BRCA2在CFRBC中的brca1/brca2突变的普遍性以及在CFRBC中涉及乳腺癌的新型基因的鉴定。寻求对这些数据，DNA和问卷管理的这些模块的贡献。该澳大利亚注册中心将对CFRBC阐明乳腺癌的遗传和环境原因的努力做出重大贡献，并将其转化为对乳腺癌风险或受影响的妇女的好处。