Adult Optical Non-Invasive Brain Oxygenation Monitor

成人光学无创脑氧合监测仪

• 批准号: 6585412
• 负责人: BO CHEN
• 金额: $ 10万
• 依托单位: CAS MEDICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6585412
• 关键词: artificial intelligence; bioimaging /biomedical imaging; biomedical equipment development; brain circulation; infrared spectrometry; noninvasive diagnosis; optics; oxygen transport; patient monitoring device; respiratory oxygenation; swine

DESCRIPTION (provided by applicant): There is a need for a non-invasive and continuous bedside monitor for brain oxygenation for adult human patients. Near-infrared spectroscopy (NIRS) is an optically based technique that could meet such demand. However, NIRS instruments have yet to achieve their initially expected potential of becoming routine clinical monitors complementary to pulse oximetry. One major challenge is to develop an optical transducer probe and a corresponding algorithm to solve the problem of interference from extracerebral tissue (skin, scalp, and skull) in adult NIRS applications. Another major challenge is to develop an algorithm that will be able to absolutely quantify the optical signals to derive quantitative variables or indices that are of clinical significance. Our goal is to resolve these challenges to develop an NIRS monitor that will determine absolute brain hemoglobin oxygen saturation on adult patients. The primary objectives of this SBIR proposal are: 1) Design and construct an NIRS monitor for use on adult human patients; 2) Determine the optimum adult NIRS probe configuration to minimize extracerebral interference 3) Evaluate and validate novel adult NIRS algorithms that further minimize extracerebral interference and determine absolute brain oxygen saturation.

描述（由申请人提供）：需要非侵入性且连续的床旁监测仪，以供成人人类患者脑充电。近红外光谱（NIRS）是一种基于光学的技术，可以满足这种需求。 但是，NIRS仪器尚未达到其最初成为常规临床监测器与脉搏血氧饱和度互补的预期潜力。一个主要的挑战是开发光学传感器探针和相应的算法，以解决成人NIRS应用中脑外组织（皮肤，头皮和头骨）干扰的问题。另一个主要挑战是开发一种算法，该算法将能够绝对量化光学信号，以得出具有临床意义的定量变量或指数。我们的目标是解决这些挑战，以开发NIRS监测器，以确定成人患者的绝对脑血红蛋白氧饱和度。 该SBIR提案的主要目标是：1）设计和构建NIRS监视器，以用于成人人类患者； 2）确定最佳的成年NIR探针构型，以最大程度地减少脑外干扰3）评估和验证新型的成年NIRS算法，这些算法进一步最小化脑外干扰并确定绝对的脑氧饱和度。

项目成果

A validation method for near-infrared spectroscopy based tissue oximeters for cerebral and somatic tissue oxygen saturation measurements.

• DOI: 10.1007/s10877-017-0015-1
• 发表时间: 2018-04
• 期刊: Journal of clinical monitoring and computing
• 影响因子: 2.2
• 作者: Benni PB;MacLeod D;Ikeda K;Lin HM
• 通讯作者: Lin HM

Mathematical model for describing cerebral oxygen desaturation in patients undergoing deep hypothermic circulatory arrest.

用于描述深低温停循环患者脑氧饱和度下降的数学模型。

• DOI: 10.1093/bja/aep335
• 发表时间: 2010
• 期刊: British journal of anaesthesia
• 影响因子: 9.8
• 作者: Fischer,GW;Benni,PB;Lin,H-M;Satyapriya,A;Afonso,A;DiLuozzo,G;Griepp,RB;Reich,DL
• 通讯作者: Reich,DL

The accuracy of a near-infrared spectroscopy cerebral oximetry device and its potential value for estimating jugular venous oxygen saturation.

• DOI: 10.1213/ane.0000000000000463
• 发表时间: 2014-12
• 期刊: Anesthesia and analgesia
• 影响因子: 5.7
• 作者: Ikeda K;MacLeod DB;Grocott HP;Moretti EW;Ames W;Vacchiano C
• 通讯作者: Vacchiano C