Optical Cerebral Hemodynamics Monitor

光学脑血流动力学监测仪

• 批准号: 6644589
• 负责人: BO CHEN
• 金额: $ 10万
• 依托单位: CAS MEDICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2004-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6644589
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; brain circulation; dyes; hemodynamics; infrared spectrometry; optics; oxygen transport; patient monitoring device; swine

DESCRIPTION (provided by applicant): There is a need for a bedside monitor of cerebral hemodynamics for human patients. Near-infrared spectroscopy (NIRS) is an optically based technique that could meet such demand. Using a non-toxic near infrared dye Indocyanine green (ICG) as a tracer, cerebral blood flow (CBF) can be measured with NIRS using the Fick principle. However, NIRS based cerebral hemodynamics monitor is not yet widely used in routine clinical monitoring. One major challenge is to develop an optical probe and a corresponding algorithm to solve the problem of interference from extracerebral tissue (skin, scalp, and skull) in adult NIRS applications. Another challenge is to develop a simple accurate algorithm that will be able to quantify the arterial and cerebral ICG concentrations, which are required for CBF calculation with the Fick principle. Our goal is to resolve these challenges to develop an NIRS monitor that has an integrated probe to simultaneously measure arterial and true brain tissue ICG concentrations for quantification cerebral hemodynamics. The primary objectives of this SBIR proposal are: Design and construct a NIRS hemodynamic monitoring the system; determine the optimum integrated NIRS probe configuration to minimize extracerebral interference of brain tissue ICG concentration measurement; and evaluate feasibility of proposed algorithms and validate NIRS hemodynamics parameters in animal models.

描述（由申请人提供）：需要针对人类患者的脑血液动力学的床旁监测器。近红外光谱（NIRS）是一种基于光学的技术，可以满足这种需求。可以使用FICK原理以NIR来测量无毒的近红外染料吲哚苷绿（ICG）作为示踪剂，可以用NIR进行测量。但是，基于NIRS的脑血液动力学监测仪尚未广泛用于常规临床监测。一个主要的挑战是开发光学探针和相应的算法，以解决成人NIRS应用中脑外组织（皮肤，头皮和头骨）干扰的问题。另一个挑战是开发一种简单的精确算法，该算法将能够量化动脉和脑ICG浓度，这是使用FICK原理计算所需的。我们的目标是解决这些挑战，以开发NIRS监测仪，该监测器具有集成的探针，以同时测量动脉和真实的脑组织ICG浓度以进行定量脑血液动力学。 该SBIR提案的主要目标是：设计和构建系统的血液动力学监测；确定最佳综合NIRS探针构型，以最大程度地减少脑组织ICG浓度测量的脑外干扰；并评估提出的算法的可行性并验证动物模型中的NIRS血液动力学参数。