Brain Trauma Assessment System

脑外伤评估系统

• 批准号: 6550298
• 负责人: JOHN Milton SEWELL
• 金额: $ 9.94万
• 依托单位: ACTIVE SIGNAL TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6550298
• 关键词: biomedical equipment development; brain disorder diagnosis; clinical research; coma; diagnosis design /evaluation; disease /disorder etiology; emergency care; head /neck injury; human subject; noninvasive diagnosis; portable biomedical equipment; unconsciousness; biomedical equipment development; brain disorder diagnosis; clinical research; coma; diagnosis design /evaluation; disease /disorder etiology; emergency care; head /neck injury; human subject; noninvasive diagnosis; portable biomedical equipment; unconsciousness

DESCRIPTION (provided by applicant): With over 1.5 million persons suffering head injury annually in the U.S., and approximately 50,000 dying from these injuries, a need exists for early direct assessment of brain injury. Currently, injuries must be inferred from Glascow Coma Scores (GCS), low blood pressure, and/or low pulse oximetry, but there is no direct method of measuring brain condition at the scene. Active Signal proposes to test a small, portable, hand-held device to perform non-invasive measurements of brain injury, allowing direct assessment of injury even with lack of patient responsiveness. Thus, brain injury will be distinguished from low CGS caused by drugs, alcohol and hypoglycemia, and the information used for triaging and even early intervention. The brain trauma assessment system (BTAS) is modeled on one that has successfully identified neurological status on >150 trauma patients at the University of Maryland Shock Trauma Center (STC). Here, EMTs will use the BTAS on patients at the scene of injury and during transport. The measurements will be compared to the diagnosis upon admission to the STC to evaluate the device's sensitivity and specificity. Active Signal will make adjustments to accommodate demands of the EMS environment in preparation for a broad study in Phase II.

描述（由申请人提供）：美国每年有超过150万人遭受头部受伤，约有50,000人死于这些伤害，需要早日直接评估脑损伤。当前，必须从Glascow昏迷评分（GCS），低血压和/或低脉搏血氧饱和血氧饱和度计推断出伤害，但没有直接测量现场脑状况的方法。 Active Signal建议测试一个小型，便携式，手持设备，以对脑损伤进行非侵入性测量，即使缺乏患者反应能力，也可以直接评估损伤。因此，脑损伤将与由药物，酒精和低血糖症引起的低CG区分开，以及用于分列甚至早期干预的信息。脑创伤评估系统（BTA）是基于成功鉴定出在马里兰大学休克创伤中心（STC）上成功鉴定出> 150名创伤患者神经系统状况的模型的。在这里，EMT将在受伤现场和运输期间对患者使用BTA。将测量值与入院后的诊断进行比较，以评估设备的敏感性和特异性。主动信号将进行调整以适应EMS环境的需求，以准备在II阶段进行广泛研究。