Independent and Dependent Life in the Elderly

老年人的独立和依赖生活

• 批准号: 6621498
• 负责人: DAVID A. SNOWDON
• 金额: $ 102.39万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6621498
• 关键词: Alzheimer's disease; aging; apolipoprotein E; cerebrovascular disorders; clinical research; cognition disorders; dementia; disease /disorder proneness /risk; education; functional ability; hippocampus; human old age (65+); human subject; human very old age (85+); language; lifestyle; longevity; longitudinal human study; magnetic resonance imaging; memory; neuritic plaques; neuroanatomy; neurofibrillary tangles; postmortem; prognosis; synaptophysin

DESCRIPTION (provided by applicant): This grant application is a continuation of a longitudinal study of aging and Alzheimer's disease in a defined population of 678 Catholic sisters who were 75 to 102 years old when the study began in 1991. By the end of 2001, approximately 250 survivors will range in age from 85 to as old as 107 years. The continuation of the Nun Study will provide valuable data on the oldest old (85+), the fastest growing segment of the American population. Early and late life risk factors documented in convent archives, annual assessments of cognitive and physical function, and brain donation by all participants make the Nun Study a unique resource. Because of the high level of homogeneity of adult lifestyles, many factors that confound other epidemiologic studies will be eliminated or minimized, such as smoking, occupation, reproductive history, and access to health care. More than ten years of extensive data collection provide us with the opportunity to describe the natural history of cognitive dysfunction from intact cognitive status, to mild cognitive impairment, to early and late stages of dementia. At the other extreme, our data allow us to investigate the determinants of survival and successful aging in the very old. Our study also is enhanced by combining the gross and microscopic findings from autopsies with data from postmortem MR images. Aim I. Mild cognitive impairment: Identify risk factors for both the development of mild cognitive impairment and its conversion to dementia. Determine if the risk factors for the development of mild cognitive impairment are different from those for the conversion to dementia. Aim II. Alzheimer's disease and dementia: Determine why some individuals with relatively little neuropathology succumb to the clinical manifestations of dementia, while others with severe neuropathology do not develop dementia. Furthermore, describe how this difference in the clinical expression of neuropathology is due in part to early life factors as well as increasing age. Aim Ill. Successful aging and longevity: Describe the relationship of Alzheimer's and cerebrovascular pathology to successful aging and longevity, and the role early life factors play in this relationship.

描述（由申请人提供）：此赠款申请是延续 定义的纵向研究和阿尔茨海默氏病的纵向研究 研究后，有678个天主教姐妹的人口为75至102岁 始于1991年。到2001年底，大约250个幸存者将范围 年龄从85岁到107岁。修女研究的继续 提供有关最古老的旧（85+）的宝贵数据，这是增长最快的段 美国人口。 修道院档案中记录的早期和晚期危险因素，年度 评估认知和身体机能，以及所有人的大脑捐赠 参与者使修女研究成为独特的资源。由于高水平 成人生活方式的同质性，许多因素使其他流行病学混淆 研究将被消除或最小化，例如吸烟，职业， 生殖历史和获得医疗保健。超过十年 广泛的数据收集为我们提供了描述的机会 从完整的认知状况到轻度的认知功能障碍的自然历史 认知障碍，到痴呆的早期和晚期。在另一个 极端，我们的数据使我们能够调查生存的决定因素和 成功的老化。我们的研究也通过结合 来自尸检的总发现和微观发现，并带有尸体MR的数据 图像。 目标I.轻度认知障碍：确定这两者的风险因素 轻度认知障碍的发展及其转化为痴呆症。 确定出现轻度认知障碍的风险因素是否 与转化为痴呆的不同。 目标II。阿尔茨海默氏病和痴呆症：确定为什么有些人 相对较少的神经病理学屈服于 痴呆症，而其他患有严重神经病理学的其他则不会发展痴呆。 此外，描述了如何在临床表达中的这种差异 神经病理学部分是由于早期生命因素以及年龄增长。 目标生病。成功的衰老和长寿：描述 阿尔茨海默氏症和脑血管病理的成功衰老和寿命， 早期生活因素在这种关系中起着作用。