Technological Innovations for the Remote Monitoring of Smoking in Adolescents

青少年吸烟远程监测的技术创新

基本信息

  • 批准号:
    9307742
  • 负责人:
  • 金额:
    $ 15.44万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-07-01 至 2019-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Dr. McClure is a [Research Instructor] in the Clinical Neuroscience Division of the Department of Psychiatry and Behavioral Sciences at the Medical University of South Carolina (MUSC). Dr. McClure seeks a Mentored Research Scientist Development Award (K01) through the National Institute on Drug Abuse. This award will provide the essential training to facilitate her transition to independence to pursue a research agenda focused on technological innovations to advance smoking cessation in adolescents. Candidate. Dr. McClure is a behavioral psychologist with extensive preclinical and clinical training in the areas of substance abuse research and treatment, with a specific focus on tobacco and cannabis dependence. Dr. McClure requires career development through the K01 award in order to realize her long-term goals focused in the multidisciplinary research of smoking and relapse and how that knowledge can inform personalized, patient-centered treatment interventions. Dr. McClure has carefully devised a structured career development plan for the 5-year K01 award period. Dr. McClure's objectives will be to: 1) obtain training in mobile health (mHealth), including extensive knowledge of methodology, analyses, engineering, and privacy/confidentiality concerns; [2) obtain biostatistical training in the analysis of longitudina data]; 3) broaden understanding of adolescent smoking cessation and addiction; 4) expand understanding in conducting randomized clinical trials; and [5) improve grant writing skills to successfully transition to research independence.] Environment. MUSC is a collaborative, productive environment that will provide the ideal setting for Dr. McClure to receive mentored career development through the K01 award. Research productivity is stellar, with 1,242 extramural grants awarded during FY2012, totaling more than $232 million. MUSC has a strong addictions focus, and ranks among the top 10 medical schools in the country for drug and alcohol abuse medical education. Over 30 faculty are engaged in training and research in addiction across departments and disciplines. The Department of Psychiatry and Behavioral Sciences ranks 7th in NIH research funding among domestic psychiatry departments, with faculty receiving 173 grant and contract awards, totaling $40.8 million in FY2012. All study procedures will take place through the Clinical Neuroscience Division (CND; Director, McRae-Clark), where the candidate, Primary Mentor (Gray) and Co-Mentor (Brady) hold appointments. The CND provides the infrastructure and dedicated space for successful execution of study procedures. Technological expertise, training, and software development will be provided by the Technology Applications Center for Healthful Lifestyles (TACHL) within the School of Nursing at MUSC, which is directed by Dr. Frank Treiber (Co-Mentor). [Biostatistical training and coursework will be provided through the Department of Public Health Sciences, where the candidate's Co-Mentor (Ramakrishnan) holds an appointment.] MUSC offers several resources to Early Career Investigators, such as pilot funds, seminars, grant writing courses and consultations, mock study sections, and research and recruitment services through the South Carolina Clinical and Translational Research Institute and the Offices of Research Development and Sponsored Programs Research. Cigarette smoking is the leading cause of preventable death in the US, with the vast majority of adult smokers starting prior to age 18. Understanding the process of relapse to smoking during a quit attempt is critical for the development of highly efficacious treatment interventions, yet little is known about the natural history of relapse among adolescent smokers. Technological innovations for the remote monitoring of smoking that do not primarily rely on self-report would allow for the fine-grained analysis of relapse and may be a highly fruitful avenue to explore. The studies in this K01 application propose to develop and evaluate a comprehensive remote monitoring system combining self-reports of smoking through ecological momentary assessment (EMA) with biochemical verification of smoking through breath carbon monoxide (CO) in adolescents (ages 14-21). In Aim 1, feasibility, acceptability, and compliance of the EMA + CO system will be evaluated during 1 week of smoking through quantitative and qualitative methods (Experiment 1). Experiment 2 will then monitor relapse to smoking following a quit attempt and compare the EMA + CO system vs. traditional EMA alone plus weekly clinic visits to obtain biochemical verification of smoking. In Aim 2, agreement between CO and self-reported smoking across groups will be compared. Participants in the EMA + CO group are expected to exhibit higher agreement between self-reported smoking and CO verification compared to the EMA alone group. Additionally, in Exploratory Aim 1, the trajectory of relapse following a quit attempt will be characterized across groups. Finally, in Exploratory Aim 2, EMA ratings of situational and momentary states will be compared during smoking and non-smoking occasions. The remote monitoring of smoking allows for the fine-grained characterization of behavioral processes, rather than outcomes that may not capture the complex process of relapse. The evaluation of this system is a critical first step in the eventual goal of facilitating its use for future studies to answer questions regarding relapse. Thi knowledge can then inform maximally effective, just-in-time interventions delivered at critical moments to promote long-term abstinence.
描述(由申请人提供):McClure 博士是南卡罗来纳医科大学 (MUSC) 精神病学和行为科学系临床神经科学部的[研究讲师]。麦克卢尔博士通过国家药物滥用研究所寻求指导研究科学家发展奖 (K01)。该奖项将提供必要的培训,以促进她向独立过渡,以追求以技术创新为重点的研究议程,以促进青少年戒烟。候选人。麦克卢尔博士是一位行为心理学家,在药物滥用研究和治疗领域接受过广泛的临床前和临床培训,特别关注烟草和大麻依赖。 McClure 博士需要通过 K01 奖获得职业发展,以实现她的长期目标,重点是吸烟和复吸的多学科研究,以及这些知识如何为个性化、以患者为中心的治疗干预提供信息。 McClure博士为5年K01奖励期精心设计了一个结构化的职业发展计划。 McClure 博士的目标是: 1) 获得移动医疗 (mHealth) 方面的培训,包括方法、分析、工程和隐私/保密问题方面的广泛知识; [2) 获得分析纵向数据的生物统计学训练]; 3)扩大对青少年戒烟和成瘾的认识; 4)扩大对进行随机临床试验的理解; [5) 提高资助写作技巧,以成功过渡到研究独立性。] 环境。 MUSC 是一个协作、高效的环境,将为 McClure 博士提供通过 K01 奖获得指导的职业发展的理想环境。研究生产力非常出色,2012 财年获得了 1,242 项校外资助,总额超过 2.32 亿美元。 MUSC 非常注重成瘾问题,在药物和酒精滥用医学教育方面名列全国前 10 名医学院。超过 30 名教师从事跨部门和跨学科的成瘾培训和研究。精神病学和行为科学系的NIH研究经费在国内精神病学系中排名第七,教员获得173项资助和合同奖励,2012财年总计4080万美元。所有研究程序将通过临床神经科学部门(CND;McRae-Clark 主任)进行,候选人、主要导师(格雷)和联合导师(布雷迪)在此进行任命。 CND 为成功执行研究程序提供基础设施和专用空间。技术专业知识、培训和软件开发将由 MUSC 护理学院健康生活方式技术应用中心 (TACHL) 提供,该中心由 Frank Treiber 博士(联合导师)领导。 [生物统计培训和课程将通过公共卫生科学系提供,候选人的共同导师 (Ramakrishnan) 在那里预约。] MUSC 为早期职业研究者提供多种资源,例如试点资金、研讨会、资助写作课程和通过南卡罗来纳州临床和转化研究所以及研究开发和赞助项目研究办公室提供咨询、模拟研究部分以及研究和招聘服务。在美国,吸烟是可预防死亡的主要原因,绝大多数成年吸烟者在 18 岁之前开始吸烟。了解尝试戒烟期间复吸的过程对于制定高效的治疗干预措施至关重要,但目前很少有研究了解复发的自然史 青少年吸烟者。不主要依赖于自我报告的吸烟远程监测技术创新将允许对复吸进行细粒度的分析,并且可能是一个非常富有成效的探索途径。 K01 申请中的研究建议开发和评估一个全面的远程监测系统,该系统将通过生态瞬时评估 (EMA) 进行的吸烟自我报告与通过青少年(14-21 岁)呼吸一氧化碳 (CO) 进行吸烟的生化验证相结合。在目标 1 中,将在吸烟 1 周期间通过定量和定性方法评估 EMA + CO 系统的可行性、可接受性和依从性(实验 1)。然后,实验 2 将监测尝试戒烟后的吸烟复发情况,并将 EMA + CO 系统与单独传统 EMA 加上每周门诊就诊进行比较,以获得吸烟的生化验证。在目标 2 中,将比较各组 CO 与自我报告吸烟之间的一致性。与单独 EMA 组相比,EMA + CO 组的参与者预计在自我报告吸烟和 CO 验证之间表现出更高的一致性。此外,在探索性目标 1 中,将跨组描述尝试戒烟后的复发轨迹。最后,在探索性目标 2 中,将比较吸烟和不吸烟场合下情境和瞬时状态的 EMA 评级。对吸烟的远程监测可以对行为过程进行细粒度的表征,而不是可能无法捕获复杂的复发过程的结果。对该系统的评估是促进其用于未来研究以回答有关复发问题的最终目标的关键的第一步。这些知识可以为在关键时刻提供最有效、及时的干预措施提供信息,以促进长期禁欲。

项目成果

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Erin A McClure其他文献

Erin A McClure的其他文献

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{{ truncateString('Erin A McClure', 18)}}的其他基金

The impact of cannabis and tobacco/nicotine product co-use in young adults: Prospective cessation evaluation and substitution
大麻和烟草/尼古丁产品同时使用对年轻人的影响:预期戒烟评估和替代
  • 批准号:
    10735046
  • 财政年份:
    2023
  • 资助金额:
    $ 15.44万
  • 项目类别:
SRNT 2020 Annual Meeting
SRNT 2020年会
  • 批准号:
    10039358
  • 财政年份:
    2020
  • 资助金额:
    $ 15.44万
  • 项目类别:
Determining the impact of cannabis use and severity on tobacco cessation outcomes: A prospective tobacco treatment trial
确定大麻使用及其严重程度对戒烟结果的影响:前瞻性烟草治疗试验
  • 批准号:
    10652480
  • 财政年份:
    2019
  • 资助金额:
    $ 15.44万
  • 项目类别:
Determining the impact of cannabis use and severity on tobacco cessation outcomes: A prospective tobacco treatment trial
确定大麻使用及其严重程度对戒烟结果的影响:前瞻性烟草治疗试验
  • 批准号:
    10629879
  • 财政年份:
    2019
  • 资助金额:
    $ 15.44万
  • 项目类别:
Determining the impact of cannabis use and severity on tobacco cessation outcomes: A prospective tobacco treatment trial
确定大麻使用及其严重程度对戒烟结果的影响:前瞻性烟草治疗试验
  • 批准号:
    10428622
  • 财政年份:
    2019
  • 资助金额:
    $ 15.44万
  • 项目类别:
Determining the impact of cannabis use and severity on tobacco cessation outcomes: A prospective tobacco treatment trial
确定大麻使用及其严重程度对戒烟结果的影响:前瞻性烟草治疗试验
  • 批准号:
    10183197
  • 财政年份:
    2019
  • 资助金额:
    $ 15.44万
  • 项目类别:
Evaluating N-acetylcysteine as a pharmacotherapy for tobacco use disorder
评估 N-乙酰半胱氨酸作为烟草使用障碍的药物疗法
  • 批准号:
    9502266
  • 财政年份:
    2016
  • 资助金额:
    $ 15.44万
  • 项目类别:
Evaluating N-acetylcysteine as a pharmacotherapy for tobacco use disorder
评估 N-乙酰半胱氨酸作为烟草使用障碍的药物疗法
  • 批准号:
    9302369
  • 财政年份:
    2016
  • 资助金额:
    $ 15.44万
  • 项目类别:
Technological Innovations for the Remote Monitoring of Smoking in Adolescents
青少年吸烟远程监测的技术创新
  • 批准号:
    8856191
  • 财政年份:
    2014
  • 资助金额:
    $ 15.44万
  • 项目类别:
Technological Innovations for the Remote Monitoring of Smoking in Adolescents
青少年吸烟远程监测的技术创新
  • 批准号:
    8764063
  • 财政年份:
    2014
  • 资助金额:
    $ 15.44万
  • 项目类别:

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  • 批准号:
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The Role of Endocannabinoids in Adulthood Alcohol Drinking After Adolescent Social Isolation
内源性大麻素在青少年社会隔离后成年饮酒中的作用
  • 批准号:
    10739510
  • 财政年份:
    2023
  • 资助金额:
    $ 15.44万
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Neurobiological impact of acute digital media abstinence among drug using college students
吸毒大学生急性数字媒体戒断的神经生物学影响
  • 批准号:
    10677380
  • 财政年份:
    2023
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Sex Specific Effects of Adolescent Alcohol Exposure on BNST Plasticity
青少年酒精暴露对 BNST 可塑性的性别特异性影响
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