Risk Factors for Breast Cancer in Orange County, Florida

佛罗里达州奥兰治县乳腺癌的危险因素

• 批准号: 6630339
• 负责人: JONATHAN M SAMET
• 金额: $ 8.16万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6630339
• 关键词: antidepressants; breast neoplasms; cancer risk; clinical research; depression; dosage; drug adverse effect; drug carcinogenesis; drug related neoplasm /cancer; family genetics; female; human middle age (35-64); human old age (65+); human subject; interview; mammary disorder; neoplasm /cancer epidemiology; neoplasm /cancer immunology; patient oriented research; telecommunications; women's health

DESCRIPTION (provided by applicant)Previous epidemiologic and experimental evidence suggesting a possible association between antidepressant drugs and the risk of breast cancer have several methodological weaknesses. The broad objective of this study is to investigate this association while addressing the flaws in previous studies. The primary hypothesis is that antidepressants increase the risk of breast cancer. This is a population-based case-control study. The 55-74 year-old cases to be selected from the Florida State Cancer Registry will be 400 breast cancer cases (ICD-9 code 174), diagnosed between 1/1/97 and 12/31/00, or the latest month in 2001 for which data are complete. The controls will be 400 female Orange County residents, and will be selected from Florida State Drivers' License files. They will be frequency-matched with cases on race and age (5-year intervals). Telephone interviews will be conducted by trained interviewers to collect data on past use of antidepressants, depression history and many potential confounders, using a Structured Questionnaire and the Diagnostic Interview Schedule (DIS). The data will be analyzed by means of unconditional logistic regression analysis. Odds ratios (ORs) and 95% CIs will be reported for breast cancer risk associated with antidepressant use, and will be adjusted for age, race, family history of breast cancer, alcohol, and other potential confounders. Additional analyses will include analysis stratified by depression status, dose-response analysis, and analysis for interactions between antidepressants and each of: depression, family history of breast cancer, history of benign breast disease and reproductive history. The results will be discussed in terms of implications for future use of antidepressants.

描述（由申请人提供）先前的流行病学和实验证据，表明抗抑郁药与乳腺癌风险之间可能存在几种方法学弱点。这项研究的广泛目的是研究这种关联，同时解决先前研究中的缺陷。主要假设是抗抑郁药增加了患乳腺癌的风险。这是一项基于人群的病例对照研究。从佛罗里达州癌症登记处选择的55-74岁病例将为400例乳腺癌病例（ICD-9代码174），诊断为1/1/97至12/31/00，或2001年完成数据完成的最新月份。控件将是400名橙县居民，并将从佛罗里达州司机的许可证档案中选出。他们将与种族和年龄（5年间隔）的案例相匹配。训练有素的访调员将进行电话采访，以收集有关使用结构化问卷和诊断访谈时间表（DIS）的抗抑郁药，抑郁史和许多潜在混杂因素的使用数据。数据将通过无条件的逻辑回归分析进行分析。赔率比（OR）和95％的顺式报告与抗抑郁药相关的乳腺癌风险报告，并将针对年龄，种族，乳腺癌，酒精和其他潜在混杂因素进行调整。其他分析将包括按抑郁状态分层的分析，剂量反应分析以及抗抑郁药与每种抑郁症之间的相互作用的分析：抑郁症，乳腺癌家族史，良性乳房疾病的史和生殖史。结果将以对抗抑郁药的未来使用的影响进行讨论。