Cognitive Control in Children of SUD Parents: A Longitudinal Multimodal MRI Study
SUD 父母子女的认知控制:纵向多模态 MRI 研究
基本信息
- 批准号:9103067
- 负责人:
- 金额:$ 70.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-07-01 至 2020-04-30
- 项目状态:已结题
- 来源:
- 关键词:14 year oldAccountingAddressAdolescenceAdolescentAgeAlcohol or Other Drugs useBehavioralBrainChildCognitiveConflict (Psychology)Decision MakingDevelopmentDiffusion Magnetic Resonance ImagingDimensionsEmotionalEpidemicEpidemiologyExposure toFamilyFamily history ofFrequenciesFunctional Magnetic Resonance ImagingFundingGoalsHealthHyperactive behaviorImageIndividualInformal Social ControlInterventionInvestigationLaboratoriesLifeMagnetic Resonance ImagingMeasurementMeasuresMediatingModalityMultimodal ImagingNational Institute of Drug AbuseNeurocognitiveParentsPatternPilot ProjectsPlayPrevention strategyPreventive InterventionPrincipal InvestigatorProcessPublic HealthRecording of previous eventsResearchResearch DesignRestRewardsRiskRisk FactorsRisk-TakingSample SizeSamplingStagingStimulusStructureSubstance Use DisorderTimeYouthaddictionadolescent substance usebasecognitive controlcognitive taskconflict resolutioncontextual factorscost effectivecritical perioddesigndiscountingearly adolescenceearly onsetfollow-uphigh riskimprovedneural circuitneurobehavioralneuroimagingprospectivetraittreatment strategy
项目摘要
DESCRIPTION (provided by applicant): Rates of substance use (SU) and substance use disorders (SUD) among adolescents in the US have reached epidemic proportions. An effective early prevention strategy that targets adolescents at high risk for SU/SUD by virtue of family history (FH+) would make a significant and cost-effective contribution. While this relationship is not yet well understood, recent research, including our own NIDA-funded Pilot Study (SUD and Decision-Making: A Pilot Imaging Study of Parents and Children; R21 DA031975; Principal Investigator: C Hoven) has begun to identify deficits in cognitive control, measured both behaviorally and neurobiologically, as key factors involved in adolescent SU/SUD. Our Pilot findings reveal consistently strong hyperactivity and reduced connectivity in the FH+ group in neural circuits thought to play key roles in decision making, reward and addiction. These changes are observed prior to an individuals' exposure to psychoactive substances, thus, reflecting pre- existing vulnerabilities. The findings from our Pilot Study are therefore compellin. The proposed Adolescent Brain Study (ABStudy), using MMRI's (multimodal imaging) at baseline and at 36 months, combined with three formal cognitive tasks, and a developmentally-oriented study design, which includes assessments every three months, has the goal of contributing to the open questions while improving our understanding of FH+ children and their neurobehavioral development. We will combine cutting edge MMRI with the latest neurocognitive laboratory tasks to extend and build upon our Pilot Study, both longitudinally and methodologically, drawing on a non-clinical, epidemiological sample, which has been extensively characterized (5R01DA023733-05 and 5R01DA024029-05; Principal Investigator: C. Hoven). Specifically, we will: 1) Identify the relationship between parental SUD history (FH+/-) and neurobehavioral indicators of cognitive control (behavioral and brain structure/functioning) in their children during early adolescence, 2) Examine the prospective association between FH+/- status and baseline neurobehavioral indicators of cognitive control with subsequent onset and progression of problematic SU trajectories from early adolescence through mid- adolescence, 3) Examine longitudinally associations between FH+/- status, in the development of neurobehavioral indicators of cognitive control, and onset and progression of problematic SU trajectories from early adolescence through mid-adolescence. We will study 150 substance naïve individuals, from early adolescence (ages 12-14), who come equally from FH+/FH- families, and follow them through mid-adolescence (ages 15-17). Importantly, this study will examine the neurobehavioral dimensions while simultaneously, possibly for the first time in an adolescent imaging study, taking into account socio-cultural contextual factors, known to contribute to adolescent SU.
描述(由申请人提供):美国青少年的物质使用 (SU) 和物质使用障碍 (SUD) 比例已达到流行程度。针对家庭中 SU/SUD 高风险青少年的有效早期预防策略。虽然这种关系尚未得到充分理解,但最近的研究,包括我们自己的 NIDA 资助的试点研究(SUD 和决策:家长影像学试点研究)将做出重大且具有成本效益的贡献。和儿童;R21 DA031975;首席研究员:C Hoven)已开始从行为和神经生物学角度确定认知控制缺陷,这是青少年 SU/SUD 的关键因素,揭示了 FH+ 中持续的强烈过度活跃和连通性降低。神经回路中的群体被认为在决策、奖励和成瘾中发挥着关键作用,这些变化是在接触精神活性物质之前观察到的,因此反映了我们试点的发现。因此,拟议的青少年大脑研究 (ABStudy) 在基线和 36 个月时使用 MMRI(多模态成像),结合三项正式的认知任务以及以发展为导向的研究设计,其中包括每三个月进行一次评估。我们的目标是为开放性问题做出贡献,同时提高我们对 FH+ 儿童及其神经行为发展的理解,我们将把最先进的 MMRI 与最新的神经认知实验室任务结合起来,以扩展和发展我们的试点研究。纵向和方法论上,利用已表征的非临床流行病学样本(5R01DA023733-05 和 5R01DA024029-05;首席研究员:C. Hoven)具体来说,我们将: 1) 确定父母 SUD 病史之间的关系( FH+/-)和儿童早期认知控制的神经行为指标(行为和大脑结构/功能)青春期,2) 检查 FH+/- 状态和认知控制基线神经行为指标之间的前瞻性关联,以及从青春期早期到青春期中期有问题的 SU 轨迹的后续发生和进展,3) 检查 FH+/- 状态之间的纵向关联,认知控制的神经行为指标的发展,以及从青春期早期到青春期中期有问题的 SU 轨迹的发生和进展 我们将研究 150 种物质。个体,从青春期早期(12-14 岁),同样来自 FH+/FH- 家庭,并跟踪他们到青春期中期(15-17 岁)。重要的是,这项研究将同时检查神经行为维度,可能是针对这是首次在青少年影像学研究中考虑到已知会导致青少年 SU 的社会文化背景因素。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Christina W. Hoven其他文献
Subthreshold psychiatric symptoms in a primary care group practice.
初级保健小组实践中的阈下精神症状。
- DOI:
10.1001/archpsyc.1996.01830100026004 - 发表时间:
1996-10-01 - 期刊:
- 影响因子:0
- 作者:
M. Olfson;W. Broadhead;Myrna M Weissman;A. C. Leon;L. Farber;Christina W. Hoven;R. Kathol - 通讯作者:
R. Kathol
Mental disorders and disability among patients in a primary care group practice.
初级保健团体实践中患者的精神障碍和残疾。
- DOI:
10.1176/ajp.154.12.1734 - 发表时间:
1997-12-01 - 期刊:
- 影响因子:0
- 作者:
M. Olfson;Bruce Fireman;M. Weissman;A. C. Leon;David V. Sheehan;R. Kathol;Christina W. Hoven;L. Farber - 通讯作者:
L. Farber
The association between intolerance of uncertainty and depressive symptoms during COVID-19 in New York, USA.
美国纽约 COVID-19 期间对不确定性的不容忍与抑郁症状之间的关联。
- DOI:
10.1016/j.jad.2024.04.037 - 发表时间:
2024-04-01 - 期刊:
- 影响因子:6.6
- 作者:
Mojdeh Rafieian;Norbert Skokauskas;K. Cheslack;Christina W. Hoven - 通讯作者:
Christina W. Hoven
Priorities for research promoting mental health in the south and east of Asia
促进南亚和东亚心理健康的研究重点
- DOI:
10.1016/j.lansea.2023.100287 - 发表时间:
2023-10-01 - 期刊:
- 影响因子:0
- 作者:
Christopher A. Lemon;C. Svob;Yvonne A. Bonomo;Saraswati Dhungana;S. Supanya;Napat Sittanomai;H. Diatri;I. I. Haider;Afzal Javed;Prabha Chandra;H. Herrman;Christina W. Hoven;N. Sartorius - 通讯作者:
N. Sartorius
Characteristics of Adolescents with and without a Family History of Substance Use Disorder from a Minority Cohort
少数群体中有或没有药物使用障碍家族史的青少年的特征
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
K. Cheslack;Y. Cycowicz;Diana V. Rodriguez;Lawrence V. Amsel;G. Musa;Megan Ryan;M. Bresnahan;Huilan Tang;L. Geronazzo;Adam Bisaga;Zhishun Wang;Xiaofu He;Christina W. Hoven - 通讯作者:
Christina W. Hoven
Christina W. Hoven的其他文献
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{{ truncateString('Christina W. Hoven', 18)}}的其他基金
Uncovering the Invisible Risks for Suicide: Nationally Representative Samples of Youth in Guyana
揭示自杀的隐形风险:圭亚那青少年的全国代表性样本
- 批准号:
10707231 - 财政年份:2022
- 资助金额:
$ 70.41万 - 项目类别:
Uncovering the Invisible Risks for Suicide: Nationally Representative Samples of Youth in Guyana
揭示自杀的隐形风险:圭亚那青少年的全国代表性样本
- 批准号:
10595394 - 财政年份:2022
- 资助金额:
$ 70.41万 - 项目类别:
Longitudinal Follow-Up of 9/11 Directly Exposed Children in their Age of Transition: Independence, Occupation and Morbidity
9/11 直接暴露儿童过渡期的纵向随访:独立性、职业和发病率
- 批准号:
10315787 - 财政年份:2021
- 资助金额:
$ 70.41万 - 项目类别:
Longitudinal Follow-Up of 9/11 Directly Exposed Children in their Age of Transition: Independence, Occupation and Morbidity
9/11 直接暴露儿童过渡期的纵向随访:独立性、职业和发病率
- 批准号:
10459192 - 财政年份:2021
- 资助金额:
$ 70.41万 - 项目类别:
Guyana Research in Injury and Trauma Training (GRITT) Program
圭亚那伤害和创伤训练研究 (GRITT) 计划
- 批准号:
10490413 - 财政年份:2021
- 资助金额:
$ 70.41万 - 项目类别:
Longitudinal Follow-Up of 9/11 Directly Exposed Children in their Age of Transition: Independence, Occupation and Morbidity
9/11 直接暴露儿童过渡期的纵向随访:独立性、职业和发病率
- 批准号:
10624884 - 财政年份:2021
- 资助金额:
$ 70.41万 - 项目类别:
Guyana Research in Injury and Trauma Training (GRITT) Program
圭亚那伤害和创伤训练研究 (GRITT) 计划
- 批准号:
10394622 - 财政年份:2021
- 资助金额:
$ 70.41万 - 项目类别:
Guyana Research in Injury and Trauma Training (GRITT) Program
圭亚那伤害和创伤训练研究 (GRITT) 计划
- 批准号:
10673879 - 财政年份:2021
- 资助金额:
$ 70.41万 - 项目类别:
Cognitive Control in Children of SUD Parents: A Longitudinal Multimodal MRI Study
SUD 父母子女的认知控制:纵向多模态 MRI 研究
- 批准号:
10168168 - 财政年份:2020
- 资助金额:
$ 70.41万 - 项目类别:
Uncovering the Risk Architecture of Suicidal Behaviors: a Representative Sample at High Risk: Diversity Supplement
揭示自杀行为的风险架构:高风险的代表性样本:多样性补充
- 批准号:
10469863 - 财政年份:2019
- 资助金额:
$ 70.41万 - 项目类别:
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