MEG EVOKED FIELDS AND MEMORY IN CHILDREN

MEG 诱发儿童场和记忆

• 批准号: 2035252
• 负责人: DONALD C. ROJAS
• 金额: $ 7.51万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 1998-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2035252
• 关键词: adolescence (12-20); age difference; auditory stimulus; behavioral /social science research tag; cerebral dominance; child psychology; clinical research; evoked potentials; gender difference; human subject; magnetoencephalography; middle childhood (6-11); psychoacoustics; short term memory

DESCRIPTION (Adapted from applicant's abstract): A number of disorders affecting the cognitive development of children are associated with short-term auditory memory impairments. These impairments can affect the development of attention, memory, language, and as a consequence affect achievement in later life. However, very little data have been reported concerning the normal maturation of short-term memory stores in childhood, especially with respect to the co-development of the physiological and anatomical substrates of those functions. Preliminary evidence from this laboratory concerning auditory sensory memory (echoic memory) have broad implications for the development of working memory. Maturational changes in working memory have been identified in previous research, but questions remain concerning the mechanisms driving the change. We hypothesize that developmental alterations in the persistence of echoic memory underlie the increased capacity of working memory. The long-term goal of the project is to better understand the development of early auditory memory, both in functional and structural terms, so that this knowledge may be applied to clinical disorders where dysfunction in these systems exist, such as developmental dyslexia. Using magnetoencephalographic and psychoacoustic methods, we propose to study the development of echoic memory duration in children. We hypothesize a significant decrease in the duration of echoic memory during the years spanning preadolescence and adolescence. We also believe that gender will be a mediating factor in the development of echoic memory, and hypothesize that females will mature than males. Further, consistent with our preliminary data we hypothesize that the right hemisphere echoic trace will change more rapidly than the left hemisphere trace. We will also use anatomical information from magnetic resonance imaging, combined with MEG source lateralization, to measure the location of the neural generators involved in echoic memory. We hypothesize that the cerebral asymmetries usually present in adult males will not be present before adolescence. To better understand the constraints which echoic memory duration places upon working memory, we will relate the two systems' development in our studies.

描述（改编自申请人的摘要）：多种疾病 影响儿童的认知发展与 短期听觉记忆障碍。 这些缺陷会影响 注意力、记忆力、语言的发展，从而影响 在以后的生活中取得的成就。 但报道的数据却很少 关于童年时期短期记忆存储的正常成熟， 尤其是在生理和心理的共同发展方面 这些功能的解剖学基础。 初步证据由此 关于听觉感觉记忆（回声记忆）的实验室有广泛的研究 对工作记忆发展的影响。 成熟的变化 以前的研究已经确定了工作记忆，但问题 仍然关注推动变革的机制。 我们假设 回声记忆持久性的发展变化是 工作记忆容量增加。 该项目的长期目标是 更好地了解早期听觉记忆的发展 功能和结构术语，以便这些知识可以应用于 这些系统存在功能障碍的临床疾病，例如 发育性阅读障碍。 使用脑磁图和心理声学方法，我们建议 研究儿童回声记忆持续时间的发展。 我们假设 这些年来回声记忆的持续时间显着减少 跨越青春期前和青春期。 我们也相信性别会 是回声记忆发展的中介因素，并假设 女性会比男性成熟。 此外，符合我们的 初步数据我们假设右半球回声轨迹将 变化比左半球轨迹更快。 我们还将使用 磁共振成像与脑磁图相结合的解剖信息 源偏侧化，测量神经发生器的位置 参与回声记忆。 我们推测大脑不对称 通常出现在成年男性中，在青春期之前不会出现。 到 更好地理解回声记忆持续时间所施加的限制 工作记忆，我们将在我们的研究中将这两个系统的发展联系起来。