Tulane National Primate Research Center

杜兰国家灵长类动物研究中心

• 批准号: 10889341
• 负责人: L Lee HAMM
• 金额: $ 50万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-09 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10889341
• 关键词: 2019-nCoV; Accreditation; Aging; Animal Model; Animals; Area; Automation; Award; Biomedical Research; COVID-19; COVID-19 pandemic; Cellular Immunology; Chronic; Communities; Containment; Contracts; Dedications; Development; Education; Electronics; Emerging Communicable Diseases; Employee; Engineering; Environment; Faculty; Funding; Generations; Grant; Growth; HIV/AIDS; Health; Health Sciences; Human; Infection; Infrastructure; Institution; Investments; Laboratories; Leadership; Lighting; Louisiana; Lung; Methods; Mission; Modeling; Mus; National Institute of Allergy and Infectious Disease; PET/CT scan; Pathogenicity; Performance; Play; Post-Acute Sequelae of SARS-CoV-2 Infection; Postdoctoral Fellow; Primates; Private Sector; Public Health Schools; Quality Control; Request for Applications; Research; Research Personnel; Resources; Role; SARS-CoV-2 infection; Schools; Science; Speed; Strategic Planning; System; Technology; Therapeutic Studies; Time; Training; Training Activity; Training and Education; Tropical Medicine; Tuberculosis; United States National Institutes of Health; Universities; Update; Vaccines; Vision; Work; animal care; animal resource; applied biomedical research; aspirate; base; biomedical resource; career development; comorbidity; data centers; empowerment; energy efficiency; equity, diversity, and inclusion; evidence base; imaging facilities; improved; industry partner; medical schools; mouse model; nonhuman primate; operation; outreach; programs; quality assurance; recruit; response; square foot; success; therapeutic evaluation; undergraduate student; vaccine evaluation

Project Summary – Overall The Tulane National Primate Research Center (TNPRC) is affiliated with Tulane University of Louisiana and was dedicated in 1964. The Center is part of Tulane University Health Sciences along with the School of Medicine, the School of Public Health and Tropical Medicine, and the School of Science and Engineering. The TNPRC is one of seven NIH-supported National Primate Research Centers within the National Primate Research Center Program. This application requests funding for the five-year time-period of May 1, 2023-April 30, 2028. Funds will be used to support administration, operations, animal resources, scientific research resources, a pilot research program, alteration and renovations, outreach, and education and training activities of the Center. The animal resources program is fully accredited by AAALAC with exemplary status. Significant infrastructure projects have been completed including renovation of new laboratory space and completion of the PET/CT facility within the RBL. We have completed a large infrastructure upgrade with upgraded boilers and new and increased capacity chillers, new building automation and access controls and energy efficiency lighting upgrades, as well as upgrades in stormwater and wastewater treatment improvements. The period since the last renewal of the TNPRC base grant has been a time of sustained growth and programmatic change. Total funding for the Center has increased to more than $43.8M in FY2021. The TNPRC is the only NPRC to have a Regional Biosafety Laboratory (BSL-3), which has been a key factor in obtaining funds to support numerous studies utilizing select agents, tuberculosis, and emerging infectious diseases, including a new and expanding program in SARS-CoV-2 research. Our efforts in SARS-CoV-2 have provided leadership within the NPRC system with the development of nonhuman primate models, testing therapeutics and vaccines. In addition, we developed a CoVID-19 Coordinating Center and Data Center supported by NIH, which provides coordinated and collaborative interactions with other NPRCs. The development of our strong Quality Assurance and Quality Control Program and new High Containment Research Performance Core have contributed greatly to our success during this funding period. In the next grant period, we will recruit additional faculty and expand our research efforts into chronic and comorbid conditions associated with infections and aging. We will focus on building onto our current successes with the generation of a new strategic plan that will make TNPRC the best primate center we can be and a premiere place to work for our employees.

项目摘要 - 总体 杜兰国家灵长类动物研究中心（TNPRC）与路易斯安那州杜兰大学和 该中心是杜兰大学健康科学的一部分。 医学，公共卫生与热带医学学院以及科学与工程学院。这 TNPRC是国家灵长类动物研究中的七个由NIH支持的国家灵长类动物研究中心之一 中心计划。该申请要求为2023年4月1日至2028年5月1日的五年时间周期提供资金。 资金将用于支持管理，运营，动物资源，科学研究资源，飞行员 中心的研究计划，更改和翻新，外展以及教育和培训活动。 动物资源计划已由AAALAC完全认可，具有示例地位。重要的基础设施 项目已经完成，包括改革新的实验室空间和宠物/CT的完成 RBL内的设施。我们已经完成了一个大型基础设施升级，并使用升级的锅炉和新的和 增加容量冷却器，新的建筑自动化以及访问控制以及能源效率照明 升级以及雨水和废水处理改进的升级。 自TNPRC基础赠款最后续签以来的时期一直是持续增长的时期和 程序化更改。该中心的总资金在2021财年增加到超过4380万美元。 TNPRC 是唯一具有区域生物安全实验室（BSL-3）的NPRC，这是获得的关键因素 资金支持众多利用精选药物，结核病和新兴传染病的研究， 包括SARS-COV-2研究中的新计划。我们在SARS-COV-2上的努力已提供 通过开发非人类私人模型，在NPRC系统中的领导才能测试疗法 和疫苗。此外，我们开发了一个由NIH支持的协调中心和数据中心的协调中心 它提供了与其他NPRC的协调和协作互动。我们强大的发展 质量保证和质量控制计划以及新的高遏制研究绩效核心具有 在此资助期间为我们的成功做出了巨大贡献。在下一个赠款期间，我们将招募其他 教师并将我们的研究工作扩展到与感染和感染相关的慢性和合并状况 老化。我们将专注于通过一系列新的战略计划来建立我们目前的成功 使TNPRC成为我们可以成为的最好的灵长类动物中心，也是为员工工作的首映场所。

项目成果

COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms.

COVID-19：法莫替丁、组胺、肥大细胞和机制。

• DOI: 10.21203/rs.3.rs-30934/v2
• 发表时间: 2020
• 期刊: Research square
• 作者: Malone,RobertW;Tisdall,Philip;Fremont-Smith,Philip;Liu,Yongfeng;Huang,Xi-Ping;White,KrisM;Miorin,Lisa;DelOlmo,ElenaMoreno;Alon,Assaf;Delaforge,Elise;Hennecker,ChristopherD;Wang,Guanyu;Pottel,Joshua;Smith,Nora;Hall,JulieM
• 通讯作者: Hall,JulieM

Aerosol-induced brucellosis increases TLR-2 expression and increased complexity in the microanatomy of astroglia in rhesus macaques.

• DOI: 10.3389/fcimb.2013.00086
• 发表时间: 2013
• 期刊: Frontiers in cellular and infection microbiology
• 影响因子: 5.7
• 作者: Lee KM;Chiu KB;Sansing HA;Didier PJ;Ficht TA;Arenas-Gamboa AM;Roy CJ;Maclean AG
• 通讯作者: Maclean AG

Exposure modality influences viral kinetics but not respiratory outcome of COVID-19 in multiple nonhuman primate species.

• DOI: 10.1371/journal.ppat.1010618
• 发表时间: 2022-07
• 期刊: PLoS pathogens
• 影响因子: 6.7

Receptor tyrosine kinases play a significant role in human oligodendrocyte inflammation and cell death associated with the Lyme disease bacterium Borrelia burgdorferi.

• DOI: 10.1186/s12974-017-0883-9
• 发表时间: 2017-05-30
• 期刊: Journal of neuroinflammation
• 影响因子: 9.3
• 作者: Parthasarathy G;Philipp MT
• 通讯作者: Philipp MT

Mesenchymal stem cells are attracted to latent HIV-1-infected cells and enable virus reactivation via a non-canonical PI3K-NFκB signaling pathway.

• DOI: 10.1038/s41598-018-32657-y
• 发表时间: 2018-10-02
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Chandra PK;Gerlach SL;Wu C;Khurana N;Swientoniewski LT;Abdel-Mageed AB;Li J;Braun SE;Mondal D
• 通讯作者: Mondal D