ORION: Oncology Research Integration using OHDSI-based NLP (NCI Cancer Informatics Scholar)

ORION：使用基于 OHDSI 的 NLP 进行肿瘤学研究整合（NCI 癌症信息学学者）

• 批准号: 10891217
• 负责人: Anil K Rustgi
• 金额: $ 30万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10891217
• 关键词: Address; Authorization documentation; Basic Science; Cancer Care Facilities; Cancer Center; Cancer Center Support Grant; Cancer Patient; Clinical; Clinical Sciences; Clinical Trials; Communities; Community Outreach; Data; Data Element; Data Science; Data Set; Dedications; Diagnosis; Dryness; Education and Outreach; Electronic Health Record; Faculty Recruitment; Family; Fast Healthcare Interoperability Resources; Funding; Gifts; Healthcare; Herbert Irving Comprehensive Cancer Center; Hospitals; Informatics; Infrastructure; International; Investments; Laboratory Research; Localized Malignant Neoplasm; Malignant Neoplasms; Maps; Medical; Medical center; Methods; Modeling; National Cancer Institute; Natural Language Processing; Natural Language Processing pipeline; New York; Observational Study; Oncology; Outcome; Output; Patient Care; Patients; Population Sciences; Positioning Attribute; Presbyterian Church; Publications; Regimen; Research; Research Personnel; Resource Sharing; Resources; Role; Schools; Science; Services; Site; Source; Standardization; Systems Biology; Time; Translational Research; Translations; Treatment Protocols; Trust; Tumor Biology; Universities; Work; anticancer research; authority; cancer education; cancer genomics; cancer research center director; career; community engagement; data modeling; demographics; diverse data; epigenomics; health data; innovation; insight; laboratory facility; malignant breast neoplasm; member; molecular subtypes; neoplasm registry; oligodendroglioma; precision oncology; programs; recruit; structured data; tool; tumor; tumor microenvironment

PROJECT SUMMARY The Herbert Irving Comprehensive Cancer Center (HICCC) was designated as a National Cancer Institute (NCI) Cancer Center in 1972 and gained comprehensive status in 1979. The HICCC is the critical driver of cancer scientific research, clinical trials, innovative patient care, cancer education and training and community outreach at Columbia University's Irving Medical Center (CUIMC) and NewYork-Presbyterian Hospital (NYPH). During the current project period (2014-present), CUIMC and NYPH committed $415M for the following: (1) new research initiatives in basic, translational, clinical and population sciences with >50 strategic faculty recruitments; (2) new and expanded facilities for laboratory research, dry bench research and clinical activities; (3) major faculty recruitments; and, (4) support of the HICCC's administrative core. A major aspect was the recruitment of Anil K. Rustgi, MD as the HICCC Director in late 2018. Rustgi has the unequivocal authority over cancer research space and cancer care facilities and accompanying substantial resources through the transformative Irving Family Trust Gift, further reinforced through his dual roles as Associate Dean of Oncology (CUIMC) and Chief of Cancer Services (NYPH). Over this project period, there was a greater focus upon transdisciplinary cross-cutting scientific themes that catalyzed the restructuring of the scientific research programs encompassing 175 members from 34 Departments and six Schools: Cancer Genomics and Epigenomics; Tumor Biology and Microenvironment; Precision Oncology and Systems Biology; and, Cancer Population Science. Importantly, Rustgi created units dedicated to Community Outreach and Engagement (COE) and Cancer Research Career Enhancement (CRCE) and enhanced the 12 Shared Resources. The Research Programs engendered impactful science with 3,399 publications of which 626 were intra- programmatic and 456 were inter-programmatic. Total NCI funding is $26M and cancer-relevant funding is $92M. The HICCC is requesting CCSG support of $4.1M per year (total DC) for the next project period.

项目概要 赫伯特·欧文综合癌症中心 (HICCC) 被指定为国家癌症研究所 (NCI) 癌症中心于 1972 年成立，并于 1979 年获得全面地位。HICCC 是 癌症科学研究、临床试验、创新患者护理、癌症教育和培训以及社区 哥伦比亚大学欧文医学中心 (CUIMC) 和纽约长老会医院 (NYPH) 的外展工作。 在当前项目期间（2014 年至今），CUIMC 和 NYPH 承诺投入 4.15 亿美元用于以下项目：(1) 超过 50 名战略教职人员在基础、转化、临床和人口科学领域开展新的研究活动 招聘； (2) 实验室研究、干台研究和临床活动的新建和扩建设施； （三）主要师资招聘； (4) HICCC 行政核心的支持。一个主要方面是 2018 年底聘请 Anil K. Rustgi 医学博士担任 HICCC 主任。Rustgi 拥有明确的权力 癌症研究空间和癌症护理设施以及通过以下方式提供的大量资源 变革性的欧文家族信托礼物，通过他担任肿瘤学副院长的双重角色进一步得到加强 （CUIMC）和癌症服务主任（NYPH）。在此项目期间，人们更加关注 促进科学研究重组的跨学科交叉科学主题 项目包括来自 34 个系和 6 个学院的 175 名成员：癌症基因组学和 表观基因组学；肿瘤生物学和微环境；精准肿瘤学和系统生物学；并且，癌症 人口科学。重要的是，Rustgi 创建了专门负责社区外展和参与的部门 (COE) 和癌症研究职业发展 (CRCE)，并增强了 12 种共享资源。这 研究项目产生了有影响力的科学成果，发表了 3,399 篇出版物，其中 626 篇为内部出版物 程序化的，456 个是程序间的。 NCI 资助总额为 2600 万美元，癌症相关资助为 9200 万美元。 HICCC 请求 CCSG 在下一个项目期间每年提供 410 万美元的支持（总 DC）。

项目成果

Targeted deubiquitination rescues distinct trafficking-deficient ion channelopathies.

• DOI: 10.1038/s41592-020-00992-6
• 发表时间: 2020-12
• 期刊: NATURE METHODS
• 影响因子: 48
• 作者: Kanner, Scott A.;Shuja, Zunaira;Choudhury, Papiya;Jain, Ananya;Colecraft, Henry M.
• 通讯作者: Colecraft, Henry M.

The Impact of HIV on Non-AIDS defining gastrointestinal malignancies: A review.

• DOI: 10.1053/j.seminoncol.2021.09.001
• 发表时间: 2021-06
• 期刊: Seminars in oncology
• 影响因子: 4
• 作者: Pumpalova YS;Segall L;Felli R;Bhatkhande G;Jacobson JS;Neugut AI
• 通讯作者: Neugut AI

Retinal Manifestations of Mitochondrial Oxidative Phosphorylation Disorders.

• DOI: 10.1167/iovs.61.12.12
• 发表时间: 2020-10-01
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: Oh JK;Lima de Carvalho JR Jr;Nuzbrokh Y;Ryu J;Chemudupati T;Mahajan VB;Sparrow JR;Tsang SH
• 通讯作者: Tsang SH

Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma.

• DOI: 10.1038/s41467-021-25501-x
• 发表时间: 2021-09-01
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Nguyen TTT;Shang E;Shu C;Kim S;Mela A;Humala N;Mahajan A;Yang HW;Akman HO;Quinzii CM;Zhang G;Westhoff MA;Karpel-Massler G;Bruce JN;Canoll P;Siegelin MD
• 通讯作者: Siegelin MD

Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants.

• DOI: 10.1016/j.omtn.2023.102032
• 发表时间: 2023-12-12
• 期刊: MOLECULAR THERAPY NUCLEIC ACIDS
• 作者: Blomquist, Viggo G.;Niu, Jacqueline;Choudhury, Papiya;Al Saneh, Ahmad;Colecraft, Henry M.;Ahern, Christopher A.
• 通讯作者: Ahern, Christopher A.