10-Year Changes in Objectively-Measured Physical Activity and Sedentary Behavior in the CARDIA Cohort

CARDIA 队列中客观测量的体力活动和久坐行为的 10 年变化

• 批准号: 9130387
• 负责人: Kelley Pettee Gabriel
• 金额: $ 68.92万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9130387
• 关键词: Acute; Address; Adult; Aerobic; Age; Age-Years; Aging; American; Ancillary Study; Atherosclerosis; Behavior; Biological Assay; Calibration; Cardiovascular Diseases; Cardiovascular system; Cell Aging; Chronic; Chronic Disease; Clinical; Cohort Studies; Collection; Coronary Artery Risk Development in Young Adults Study; Coronary artery; DNA; Data; Demographic Factors; Development; Disease; Disease Marker; Disease Outcome; Dyslipidemias; Epidemiologic Studies; Event; Exercise; Funding; Gender; Goals; Gold; Guidelines; Health; Health Benefit; Health Promotion; Heart failure; Hypertension; Individual; Knowledge; Length; Leukocytes; Life; Light; Maintenance; Measurement; Measures; Methods; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Onset of illness; Outcome; Participant; Patient Self-Report; Pattern; Performance; Physical Function; Physical activity; Population; Population Study; Positioning Attribute; Procedures; Protocols documentation; Psychosocial Factor; Public Health; Quality of life; Race; Research Design; Risk; Risk Factors; Risk Marker; Role; Site; Social Network; Stroke; Symptoms; Testing; Time; Treadmill Tests; Walking; Woman; Work; age effect; base; behavior change; cardiometabolic risk; cardiovascular disorder risk; cognitive function; cognitive performance; cohort; depressive symptoms; disability; disorder prevention; disorder risk; high risk; light intensity; men; meter; middle age; performance tests; prospective; public health research; sedentary; telomere; young adult

 DESCRIPTION (provided by applicant): Given the aging of the U.S. population, identifying strategies to optimize disease prevention and promote successful aging has important public health significance. Although the health benefits of regular moderate to vigorous intensity physical activity (MVPA) are well established, the health benefits of light intensity PA, the changes in PA and sedentary behavior (SB) during adulthood, and the role of these changes in health promotion and disease prevention are largely unknown. With data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, the overall goal of this proposal is to evaluate the 10-year changes in objectively- measured PA and SB from early (ages 38-50) to late (ages 48-60) midlife in relation to cardiovascular disease risk and markers of successful aging, including physical and cognitive function and leukocyte telomere length (a cellular marker of cardiovascular aging). Participants will be all those who attend the CARDIA Year 30 core exam (June 2015 to May 2016) and agree to the ancillary study procedures (n~2,928). The protocol will include: 1) seven days of accelerometry (ActiGraph wGT3X-BT); 2) physical performance tests; and 3) DNA extraction from stored buffy coats for assays of leukocyte telomere length. Year 30 cognitive function data will come from a separately funded ancillary study. In addition, 100 participants from each race/gender group (total n=400) will participate in a sub-study designed to validate the 400 meter walk physical performance test as a measure of aerobic capacity, using the duration of a symptom-limited graded exercise treadmill test as the gold standard. These same 400 participants will also participate in a calibration study to adjust estimates of PA and SB from the Actigraph 7164 (used at Year 20) to the Actigraph wGT3X-BT. To accomplish these goals, we propose the following specific aims: 1) Describe patterns of change in accelerometer-measured PA and SB over 10-years and determine if these patterns vary by race, gender, and other socio-demographic and psychosocial factors; 2) Investigate independent and interactive associations of declines, maintenance (high vs. low), and increases in objectively-measured PA and SB over 10-years with risk of cardiometabolic disease (obesity, hypertension, dyslipidemia, type 2 diabetes mellitus, subclinical atherosclerosis, and clinical endpoints) at Year 30; and 3) Investigate independent and interactive associations of declines, maintenance, and increases in objectively- measured PA and SB over 10-years on cellular aging (from Years 20 to 30) and, on Year 30 cognitive and physical functioning. This proposed work has important public health significance because CARDIA will be the first U.S. cardiovascular cohort study with repeat, objective measures of PA and SB, uniquely positioning this study to examine the effects of PA and SB change on relevant indicators of successful aging and disease risk within an initially young and healthy biracial study population that is now middle-aged and at increasing risk for onset of disease and disability.

 描述（由申请人提供）：鉴于美国人口的老龄化，确定优化疾病预防和促进成功老龄化的策略具有重要的公共卫生意义，尽管定期中度至剧烈强度体力活动（MVPA）对健康的益处已得到充分证实，根据年轻人冠状动脉风险发展 (CARDIA) 的数据，光强度 PA 的健康益处、成年期 PA 和久坐行为 (SB) 的变化以及这些变化在健康促进和疾病预防中的作用在很大程度上尚不清楚。 ）研究中，该提案的总体目标是评估中年早期（38-50 岁）到中年晚期（48-60 岁）客观测量的 PA 和 SB 的 10 年变化与心血管疾病风险和成功标志的关系。衰老，包括身体和认知功能以及白细胞端粒长度（心血管衰老的细胞标志）。参与者将是所有参加 CARDIA Year 30 核心考试（2015 年 6 月至 5 月）的人。 2016）并同意辅助研究程序（n~2,928），该方案将包括：1）7 天的加速测量（ActiGraph wGT3X-BT）；2）物理性能测试；以及 3）从储存的血沉棕黄层中提取 DNA 以进行分析。 30 年认知功能数据将来自一项单独资助的辅助研究，每个种族/性别有 100 名参与者。小组（总共 n = 400）将参加一项子研究，旨在验证 400 米步行身体表现测试作为有氧能力的衡量标准，使用症状限制分级运动跑步机测试的持续时间作为黄金标准。 400 名参与者还将参加一项校准研究，将 Actigraph 7164（第 20 年使用）的 PA 和 SB 估计值调整到 Actigraph wGT3X-BT 来完成。为了实现这些目标，我们提出以下具体目标： 1) 描述 10 年来加速度计测量的 PA 和 SB 的变化模式，并确定这些模式是否因种族、性别以及其他社会人口和社会心理因素而变化 2) 调查； 10 年来客观测量的 PA 和 SB 的下降、维持（高与低）和增加与心脏代谢疾病（肥胖、高血压、血脂异常、2 型糖尿病、亚临床动脉粥样硬化和临床终点）在第 30 年；以及 3）研究 10 年来客观测量的 PA 和 SB 的下降、维持和增加与细胞衰老的独立和交互关系（从20 至 30），以及关于 30 岁认知和身体功能的研究，这项拟议的工作具有重要的公共卫生意义，因为 CARDIA 将是美国第一个心血管队列研究，对 PA 和 SB 进行重复、客观测量，该研究的独特定位是检验 PA 和 SB 变化对最初年轻且健康的混血儿研究人群（现在已是中年）中成功衰老和疾病风险相关指标的影响以及患病和残疾的风险增加。