Predoctoral Training Program in Signaling and Cellular Regulation INCLUDE Down Syndrome Supplement

信号传导和细胞调节博士前培训计划包括唐氏综合症补充剂

基本信息

批准号：
10851494
负责人：
NATALIE G. AHN
金额：
$ 18.14万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10851494
关键词：
Down Syndrome Signal Transduction Training Programs cell growth regulation pre-doctoral

项目摘要

SUMMARY The goal of the NIGMS T32 Predoctoral Training Program in Signaling and Cell Regulation is to prepare predoctoral trainees for productive research careers in the field of signaling and cellular regulation. The training faculty mentors consist of an outstanding, internationally recognized group of researchers in the Department of Biochemistry (BCHM) and the Department of Molecular, Cellular and Developmental Biology (MCDB) at the University of Colorado, Boulder, who study basic cell regulatory mechanisms through discovery and characterization of key components in biological pathways. The program mentors students to gain critical thinking skills and depth in understanding how to assimilate different scientific areas to solve problems in modern molecular biosciences, and teaches them how to use apply these skills when they enter the biomedical research workforce. Program elements include program-specific elective courses, an annual Symposium, Supergroup research conferences, seminars, and journal clubs, together with trainee monitoring through thesis committees and organizational meetings. These approaches expose students to broad, interdisciplinary scientific areas through cross-disciplinary mentorship and collaboration; provide them with rigorous training in experimental design, classical and modern technologies, and data analysis, with high standards for reproducibility; foster a proactive community effort to promote the recruitment and retention of underrepresented trainees; and support students’ progress and ability to work in teams in an inclusive environment through all aspects of their training. Coursework on responsible conduct of research instills students with an awareness of norms and expectations for conducting research with high ethical standards. Professional development and career training workshops expose students to diverse career trajectories and opportunities, with experiential coaching for planning and landing employment. By integrating SCR Program- specific coursework and activities with departmental graduate program requirements, and through mindful and responsive mentoring, the Program creates a thriving collaborative and interdisciplinary graduate training environment. The current proposal requests an INCLUDE Down syndrome supplement to the existing parent T32 program. As articulated in the proposal, 10 of the 36 SCR Training Program faculty and their students are already actively engaged in Down syndrome-related research and training of graduate students and postdocs in this field. Thus, the SCR Training Program is well positioned, both scientifically and administratively, to oversee the mentorship of graduate students interested in Down syndrome-related research. Therefore, this proposal is perfectly aligned with the NIH INCLUDE Project Research Plan Component 1: Targeted high risk - high reward basic science studies in areas highly relevant to Down syndrome.

概括 NIGMS T32信号传导和细胞调节中的T32前训练计划的目标是为信号传导和细胞调节领域中的生产研究职业准备前培训。培训教师导师包括一个杰出的国际认可的研究人员生物化学系（BCHM）和分子，细胞和发育生物学系（MCDB）在科罗拉多大学，博尔德分校，他们通过发现研究基本的细胞调节机制并表征生物途径中的关键组成部分。思考技巧和深度了解如何到达工作现代分子生物科学，并教他们如何使用这些技能时如何使用这些技能生物医学研究工作人员包括计划特定的选修课程研讨会，超级研究会议，研讨会和期刊俱乐部，以及学员监视通过论文委员会和组织会议。跨学科科学领域通过交叉跨学科和协作）实验设计，古典技术和现代技术以及数据分析的严格培训，繁殖标准；代表不足的学员；通过培训的各个方面的环境。认识到正常的正常和epcection的学生，以高道德标准进行研究。专业发展和职业培训研讨会使学生了解各种职业轨迹和机会，通过整合Scrogram的经验教练来计划和着陆。具有部门研究生课程要求的特定课程和活动，虽然有意义。和响应指导，该计划创建了一个蓬勃发展的合作和跨学科研究生培训环境。当前的提案请求包括唐氏综合症的建议计划中的计划。已经积极从事唐氏综合症有关的研究和研究生和博士后的培训因此，在这个领域。因此，监督研究生的指导与唐氏综合症有关的研究提案与NIHO完全一致，包括项目研究计划组件1：针对性的高风险 - 高奖励与唐氏综合症高度相关的地区的基础科学研究。

项目成果

期刊论文数量（202）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Enhancer RNA profiling predicts transcription factor activity.

DOI：
10.1101/gr.225755.117
发表时间：
2018-03-01
期刊：
Genome research
影响因子：
7
作者：
Azofeifa JG;Allen MA;Hendrix JR;Read T;Rubin JD;Dowell RD
通讯作者：
Dowell RD

Design and application of genetically encoded biosensors.

DOI：
10.1016/j.tibtech.2010.12.004
发表时间：
2011-03
期刊：
TRENDS IN BIOTECHNOLOGY
影响因子：
17.3
作者：
Palmer, Amy E.;Qin, Yan;Park, Jungwon Genevieve;McCombs, Janet E.
通讯作者：
McCombs, Janet E.

Structure of mediator of RhoA-dependent invasion (MRDI) explains its dual function as a metabolic enzyme and a mediator of cell invasion.

RhoA 依赖性侵袭介质 (MRDI) 的结构解释了其作为代谢酶和细胞侵袭介质的双重功能。

DOI：
10.1021/bi400556e
发表时间：
2013
期刊：
Biochemistry
影响因子：
2.9
作者：
Templeton,PaulD;Litman,ElizabethS;Metzner,SandraI;Ahn,NatalieG;Sousa,MarceloC
通讯作者：
Sousa,MarceloC

Ganglioside and Non-ganglioside Mediated Host Responses to the Mouse Polyomavirus.

神经节苷脂和非神经节苷脂介导的宿主对小鼠多瘤病毒的反应。

DOI：
10.1371/journal.ppat.1005175
发表时间：
2015
期刊：
PLoS pathogens
影响因子：
6.7
作者：
You,John;O'Hara,SamanthaD;Velupillai,Palanivel;Castle,Sherry;Levery,Steven;Garcea,RobertL;Benjamin,Thomas
通讯作者：
Benjamin,Thomas

A biosensor for the activity of the "sheddase" TACE (ADAM17) reveals novel and cell type-specific mechanisms of TACE activation.