Nanoparticulate Coatings Enhance Ion Detection

纳米颗粒涂层增强离子检测

• 批准号: 10883978
• 负责人: John Albert Schultz
• 金额: $ 4万
• 依托单位: IONWERKS, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-25 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10883978
• 关键词: Acceleration; Alloys; Area; Atmosphere; Awareness; Charge; Computer software; Data; Deposition; Detection; Dose; Electronics; Electrons; Elements; Equipment; Film; Fluorescence Microscopy; Gases; Glass; Goals; Height; Helium; Image Enhancement; Individual; International; Ion Channel; Ions; Joints; Kinetics; Legal patent; Masks; Measurement; Measures; Memory; Methods; Microscope; Microscopy; Modification; Morphology; New Brunswick; Parents; Performance; Phase; Photons; Physics; Physiologic pulse; Porosity; Positron-Emission Tomography; Reaction Time; Resolution; Sales; Silicon; Source; Surface; Techniques; Technology; Testing; Thick; Thinness; Time; Transmission Electron Microscopy; United States National Institutes of Health; Universities; atomic layer deposition; catalyst; cost; data acquisition; detector; equipment acquisition; improved; innovation; interest; ion mobility; meetings; micropore; nanoparticulate; nanoscale; nanosecond; particle; particle detector; performance tests; response; solid state; success; time of flight mass spectrometry; tool

(Project Summary Changes 7/3/2023 for Equipment Supplement in bold) Ionwerks' phase II has been the catalyst by which Hamamatsu USA (Sommerville NJ) has become interested in our project and in our interaction with Rutgers University (New Brunswick NJ). In a joint meeting at Rutgers (Dec 2022) Hamamatsu made us aware of two of their new commercially released remarkable innovations: 1) A silicon based Avalanche Particle Detector (APD) which has unit sensitivity and subnanosecond pulse response to >1KeV electrons. 2) Hamamatsu's new Borosilicate MCPs coated with MgO SE emissive thin films which outperforms conventional Pb glass MCP in every way: orders of magnitude longer lifetime, higher gain --which improves with ion dose--, and a constant picosecond time response maintained at the higher gain and long lifetimes. Hamamatsu offers both for sale internationally. Addition of our Nanoparticulate thin films during our existing phase II could likely improve either of these products. However, we do not have electronics which can measure changes in picosecond pulsed timing performance and gain increase (or degradation) on the sub-nanosecond time scale. Thus the opportunity to acquire an advanced oscilloscope which would measure these parameters could not come at a more perfect time. Our previously described goals of the parent phase II application remain unaltered as follows. Ionwerks new thin film deposition technique for increasing the gain and sensitivity of existing microchannel ion detectors was proven in a previously completed NIH phase I. An increased Secondary Electron (SE) yield from these films was found to improve with ion doses of helium up to > 100 Coulombs/cm2 while the electron yield from the uncoated detector first surface decreased after 1 Coulombs/cm2. A NIH Phase II is using these films to vary elemental composition and morphology of the first surface to increase the first hit SE yield and to prolong the deposited layer lifetime. Detector testing will proceed with in-house ion and electron sources. Methods for putting these thin film coatings onto the sidewalls of the MCP (in addition to covering the front detector surface) should increase the detector gain and substantially prolong the MCP detector lifetime. We will emphasize the use of the Zeiss Orion helium ion microscope at Rutgers to perform accelerated lifetime testing of the MCP pulse height, gain and first surface secondary electron yield from individual pores. Elemental composition change in the first hit area of the microchannel pore will also be determined by Nanoscale Rutherford backscattering within the Orion and will be correlated with the lifetime and yield measurement. The combination of the Zeiss Orion helium ion microscope configured with the Ionwerks NanoRBS spectrometer should prove to be a crucial tool in detector physics. In addition the overall performance of the NanoRBS will improve when this spectrometer is retrofitted with newly enhanced MCPs combined with new APDs from this phase II effort.

（2023 年 7 月 3 日设备补充的项目摘要变更以粗体显示）Ionwerks 的第二阶段已 滨松美国（新泽西州萨默维尔）对我们的项目和 我们与罗格斯大学（新泽西州新不伦瑞克）的互动。在罗格斯大学举行的联席会议上（2022 年 12 月） 滨松让我们了解了他们在商业上发布的两项卓越创新：1) A 具有单位灵敏度和亚纳秒脉冲的硅基雪崩粒子探测器（APD） 对>1KeV电子的响应。 2) Hamamatsu 的新型硼硅酸盐 MCP 涂有 MgO SE 发射材料 薄膜在各方面都优于传统的 Pb 玻璃 MCP：长几个数量级 寿命、更高的增益（随离子剂量而提高）以及恒定的皮秒时间响应 保持较高的增益和较长的使用寿命。滨松在国际上出售这两种产品。 在我们现有的第二阶段添加我们的纳米颗粒薄膜可能会改善 这些产品中的任何一个。然而，我们没有可以测量变化的电子设备。 皮秒脉冲定时性能和亚纳秒增益增加（或降低） 时间尺度。因此有机会获得先进的示波器来测量这些 参数的出现恰逢其时。我们之前描述的父阶段目标 II 应用程序保持不变如下。 Ionwerks 新型薄膜沉积技术可提高 现有微通道离子检测器的增益和灵敏度已在先前完成的 NIH 第一阶段中得到验证。 人们发现，随着氦离子剂量的增加，这些薄膜的二次电子 (SE) 产率也会提高 到 > 100 库仑/cm2，而来自未涂层探测器第一表面的电子产额在 1 后下降 库仑/cm2。 NIH 第二阶段正在使用这些薄膜来改变第一层薄膜的元素组成和形态 表面以增加首次命中 SE 产量并延长沉积层寿命。探测器测试将 继续使用内部离子源和电子源。将这些薄膜涂层放置到侧壁上的方法 MCP 的（除了覆盖前探测器表面之外）应增加探测器增益和 显着延长 MCP 探测器的使用寿命。我们将重点强调使用 Zeiss Orion 氦离子 罗格斯大学显微镜对 MCP 脉冲高度、增益和第一表面进行加速寿命测试 各个孔的二次电子产率。第一击中区域的元素成分变化 微通道孔隙也将通过猎户座内的纳米级卢瑟福背向散射来确定，并将 与寿命和产量测量相关。蔡司Orion氦离子显微镜组合 配置了 Ionwerks NanoRBS 光谱仪应该被证明是探测器物理中的一个重要工具。在 此外，当该光谱仪采用新的技术改造时，NanoRBS 的整体性能将会提高 增强的 MCP 与第二阶段工作中的新 APD 相结合。

项目成果

Gangliosides and ceramides change in a mouse model of blast induced traumatic brain injury.

• DOI: 10.1021/cn300216h
• 发表时间: 2013-04
• 期刊: ACS chemical neuroscience
• 影响因子: 5
• 作者: A. Woods;B. Colsch;S. Jackson;Jeremy D Post;Kathrine Baldwin;Aurélie Roux;B. Hoffer;B. Cox;M. Hoffer;V. Rubovitch;C. Pick;J. Schultz;C. Balaban

Secondary Electron Emission Materials for Transmission Dynodes in Novel Photomultipliers: A Review.

• DOI: 10.3390/ma9121017
• 发表时间: 2016-12-16
• 期刊: Materials (Basel, Switzerland)
• 作者: Tao SX;Chan HW;van der Graaf H
• 通讯作者: van der Graaf H

Lipid imaging within the normal rat kidney using silver nanoparticles by matrix-assisted laser desorption/ionization mass spectrometry.

• DOI: 10.1038/ki.2015.3
• 发表时间: 2015-07
• 期刊: Kidney international
• 影响因子: 19.6
• 作者: Muller L;Kailas A;Jackson SN;Roux A;Barbacci DC;Schultz JA;Balaban CD;Woods AS
• 通讯作者: Woods AS