Prefrontal cortical circuit reorganization during immediate memory consolidation

即时记忆巩固过程中前额皮质回路重组

• 批准号: 10824532
• 负责人: Heath Larsson Robinson
• 金额: $ 6.91万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2027-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10824532
• 关键词: Address; Behavior; Behavioral; Brain region; Communication; Computer Analysis; Control Groups; Electrophysiology (science); Event; Evolution; Fiber Optics; Hippocampus; Impairment; Implant; Interneurons; Learning; Life; Light; Memory; Mission; Modification; Monitor; Mus; National Institute of Mental Health; Neurons; Output; Parvalbumins; Pattern; Performance; Physiological; Play; Prefrontal Cortex; Process; Property; Pyramidal Cells; Research Project Grants; Role; Short-Term Memory; Silicon; Structure; Synaptic plasticity; System; Testing; Time; Transgenic Mice; Tungsten; Work; cell type; cognitive function; educational atmosphere; experience; experimental study; in vivo; insight; long term memory; memory consolidation; memory encoding; memory process; memory recall; memory retrieval; neural; neurophysiology; optical fiber; optogenetics; spatial memory

PROJECT SUMMARY Learning and memory are fundamental cognitive functions that allow us to learn from the environment around us. Memory is the ability to store and recall information essential to everyday life. An indispensable property of memory is its stable storage, allowing for the recall of memories over extended periods of time. Yet the physiological mechanisms underlying the stable storage of memories for such a long-lasting time remain to be elucidated. Memory formation involves two stages, encoding, and consolidation. After encoding, the consolidation process solidifies these neuronal traces into long-lasting memories. Consolidation is a progressive process, starting with immediate consolidation that, over time, becomes long-term consolidation. The hippocampus (HPC) is a brain region fundamental to memory formation and immediate consolidation. As consolidation continues, the HPC offloads memories to the cortex, eventually becoming independent of the HPC. The HPC consolidation of memories involves a highly synchronous network event called a sharp-wave ripple (SWR). During SWRs, memory traces that represent a particular experience are replayed in a compressed manner, which is thought to consolidate these neuronal representations through synaptic plasticity. Yet, it is unknown how information from the HPC is transferred to the cortex during SWRs during immediate consolidation. A cortical region also involved in memory is the prefrontal cortex (PFC). Both the HPC and PFC are involved in spatial memory, making it an ideal behavior to investigate the transfer of HPC information to the PFC during immediate consolidation. The respective contribution of SWRs and local cortical circuit dynamics for immediate memory consolidation remains unknown. Furthermore, the circuit and cellular changes during immediate consolidation are not fully understood. This proposal targets these exact questions by 1) directly testing whether SWRs transfer information to the PFC necessary for immediate consolidation; 2) identifying the PFC neuronal assembly modifications during SWRs underlying immediate consolidation; and 3) elucidating the local PFC circuitry mechanisms that regulate these neuronal assembly changes during immediate consolidation. The aims of this proposal will directly test whether communication between HPC and PFC that occurs during SWRs is crucial for immediate memory consolidation and how local processes in the PFC evolve during memory consolidation. This work aligns with NIMH’s mission to understand the mechanisms of learning and memory at a system level by investigating the interactions between brain regions that might underlie these functions.

项目概要 学习和记忆是基本的认知功能，使我们能够从周围的环境中学习 记忆力是我们日常生活中必不可少的存储和回忆信息的能力。 记忆是其稳定的存储，可以在很长一段时间内回忆起记忆。 如此长时间稳定存储记忆的生理机制仍有待研究 阐明了记忆的形成涉及两个阶段：编码和巩固。 巩固过程将这些神经痕迹固化为持久的记忆。 渐进的过程，从立即整合开始，随着时间的推移，变成长期整合。 海马体 (HPC) 是记忆形成和即时巩固的基础大脑区域。 整合继续进行，HPC 将记忆卸载到皮层，最终独立于大脑皮层 HPC 内存整合涉及一种称为锐波的高度同步网络事件。 在 SWR 期间，代表特定经历的记忆痕迹会在 压缩方式，被认为通过突触巩固这些神经表征 然而，目前尚不清楚在 SWR 期间来自 HPC 的信息如何传输到皮层。 直接巩固也参与记忆的皮质区域是前额皮质（PFC）。 HPC 和 PFC 涉及空间记忆，使其成为研究 HPC 迁移的理想行为 立即巩固期间向 PFC 提供的信息 SWR 和局部皮质的各自贡献。 即时记忆的电路动力学仍然未知。此外，电路整合和细胞。 该提案针对的是这些具体问题。 1) 直接测试 SWR 是否将立即合并所需的信息传输给 PFC； 识别 SWR 期间 PFC 神经元组装的变化，从而实现立即巩固；3) 阐明调节这些神经组装变化的局部 PFC 电路机制 该提案的目的将直接测试HPC和之间的通信是否正确。 SWR 期间发生的 PFC 对于即时内存整合以及本地进程如何进行至关重要 PFC 在内存整合过程中不断发展，这项工作符合 NIMH 理解 PFC 的使命。 通过研究大脑区域之间的相互作用来研究系统级别的学习和记忆机制 这可能是这些功能的基础。