Prefrontal cortical circuit reorganization during immediate memory consolidation

即时记忆巩固过程中前额皮质回路重组

• 批准号: 10824532
• 负责人: Heath Larsson Robinson
• 金额: $ 6.91万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2027-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10824532
• 关键词: Address; Behavior; Behavioral; Brain region; Communication; Computer Analysis; Control Groups; Electrophysiology (science); Event; Evolution; Fiber Optics; Hippocampus; Impairment; Implant; Interneurons; Learning; Life; Light; Memory; Mission; Modification; Monitor; Mus; National Institute of Mental Health; Neurons; Output; Parvalbumins; Pattern; Performance; Physiological; Play; Prefrontal Cortex; Process; Property; Pyramidal Cells; Research Project Grants; Role; Short-Term Memory; Silicon; Structure; Synaptic plasticity; System; Testing; Time; Transgenic Mice; Tungsten; Work; cell type; cognitive function; educational atmosphere; experience; experimental study; in vivo; insight; long term memory; memory consolidation; memory encoding; memory process; memory recall; memory retrieval; neural; neurophysiology; optical fiber; optogenetics; spatial memory

PROJECT SUMMARY Learning and memory are fundamental cognitive functions that allow us to learn from the environment around us. Memory is the ability to store and recall information essential to everyday life. An indispensable property of memory is its stable storage, allowing for the recall of memories over extended periods of time. Yet the physiological mechanisms underlying the stable storage of memories for such a long-lasting time remain to be elucidated. Memory formation involves two stages, encoding, and consolidation. After encoding, the consolidation process solidifies these neuronal traces into long-lasting memories. Consolidation is a progressive process, starting with immediate consolidation that, over time, becomes long-term consolidation. The hippocampus (HPC) is a brain region fundamental to memory formation and immediate consolidation. As consolidation continues, the HPC offloads memories to the cortex, eventually becoming independent of the HPC. The HPC consolidation of memories involves a highly synchronous network event called a sharp-wave ripple (SWR). During SWRs, memory traces that represent a particular experience are replayed in a compressed manner, which is thought to consolidate these neuronal representations through synaptic plasticity. Yet, it is unknown how information from the HPC is transferred to the cortex during SWRs during immediate consolidation. A cortical region also involved in memory is the prefrontal cortex (PFC). Both the HPC and PFC are involved in spatial memory, making it an ideal behavior to investigate the transfer of HPC information to the PFC during immediate consolidation. The respective contribution of SWRs and local cortical circuit dynamics for immediate memory consolidation remains unknown. Furthermore, the circuit and cellular changes during immediate consolidation are not fully understood. This proposal targets these exact questions by 1) directly testing whether SWRs transfer information to the PFC necessary for immediate consolidation; 2) identifying the PFC neuronal assembly modifications during SWRs underlying immediate consolidation; and 3) elucidating the local PFC circuitry mechanisms that regulate these neuronal assembly changes during immediate consolidation. The aims of this proposal will directly test whether communication between HPC and PFC that occurs during SWRs is crucial for immediate memory consolidation and how local processes in the PFC evolve during memory consolidation. This work aligns with NIMH’s mission to understand the mechanisms of learning and memory at a system level by investigating the interactions between brain regions that might underlie these functions.

项目摘要 学习和记忆是基本的认知功能，使我们能够从周围的环境中学习 我们。记忆是存储和回忆日常生活必不可少的信息的能力。不可或缺的财产 内存是其稳定的存储空间，可以在长时间内回忆记忆。但是 在如此持久时间内稳定存储的稳定存储的生理机制仍然是 阐明。内存的形成涉及两个阶段，即编码和整合。编码后 合并过程将这些神经元痕迹巩固为持久的记忆。合并是 渐进的过程从立即合并开始，随着时间的流逝，它成为长期合并。 海马（HPC）是大脑区域，是记忆形成和立即巩固的基础。作为 合并继续，HPC将记忆卸载到皮质中，有时会独立于 HPC。 HPC的记忆合并涉及一个高度同步的网络事件，称为锋利的波动 波纹（SWR）。在SWR中，代表特定体验的内存迹线被重播 压缩方式，被认为可以通过突触巩固这些神经元表示 可塑性。然而，未知在SWR期间如何将HPC的信息转移到皮层 立即合并。记忆中还涉及的皮质区域是前额叶皮层（PFC）。两者 HPC和PFC参与空间记忆，使其成为研究HPC转移的理想行为 立即合并期间，向PFC提供信息。 SWR和局部皮质的相对贡献 立即内存整合的电路动力学仍然未知。此外，电路和细胞 立即合并期间的变化尚未完全理解。该建议针对这些确切的问题 通过1）直接测试SWR是否将信息传输到立即合并所需的PFC； 2） 在立即合并的SWR期间，识别PFC神经元组装的修饰； 3） 阐明调节这些神经元组件的局部PFC电路机制会发生变化 立即合并。该提案的目的将直接测试HPC和HPC之间的通信 SWR期间发生的PFC对于立即记忆巩固至关重要 记忆合并期间的PFC演变。这项工作符合NIMH的使命，以了解 通过研究大脑区域之间的相互作用，在系统层面的学习和记忆机制 这可能是这些功能的基础。