A data-driven reconceptualization of the RDoC construct of working memory: Neural correlates of underlying factors and implications for schizophrenia

工作记忆 RDoC 结构的数据驱动重新概念化：潜在因素的神经相关性及其对精神分裂症的影响

• 批准号: 10818071
• 负责人: Jared Xavier Van Snellenberg
• 金额: $ 3.19万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-17 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10818071
• 关键词: Administrative Supplement; Award; Biomedical Engineering; Categories; Clinical; Data; Data Analyses; Development; Doctor of Medicine; Doctor of Philosophy; Education; Functional Magnetic Resonance Imaging; Goals; Grant; Health; Impairment; International; Memory impairment; Methodology; Methods; Mitosis; National Institute of Mental Health; Psychiatry; Research; Research Activity; Research Domain Criteria; Research Personnel; Research Project Grants; Research Support; Research Training; Schizophrenia; Short-Term Memory; Training; Travel; Underrepresented Populations; United States National Institutes of Health; Work; behavioral and social science; blood oxygen level dependent; career; clinical training; cognitive function; computerized data processing; economic disparity; experience; graduate student; interest; multidisciplinary; neural correlate; neuroimaging; parent grant; social science research; support network; symposium; Administrative Supplement; Award; Biomedical Engineering; Categories; Clinical; Data; Data Analyses; Development; Doctor of Medicine; Doctor of Philosophy; Education; Functional Magnetic Resonance Imaging; Goals; Grant; Health; Impairment; International; Memory impairment; Methodology; Methods; Mitosis; National Institute of Mental Health; Psychiatry; Research; Research Activity; Research Domain Criteria; Research Personnel; Research Project Grants; Research Support; Research Training; Schizophrenia; Short-Term Memory; Training; Travel; Underrepresented Populations; United States National Institutes of Health; Work; behavioral and social science; blood oxygen level dependent; career; clinical training; cognitive function; computerized data processing; economic disparity; experience; graduate student; interest; multidisciplinary; neural correlate; neuroimaging; parent grant; social science research; support network; symposium

Project Summary This is an application for an administrative supplement under PA-21-071 (Research Supplements to Promote Diversity in Health-Related Research), in order to support a graduate phase M.D./Ph.D. dual degree trainee in Biomedical Engineering who originates from an Underrepresented Population in the U.S. Biomedical, Clinical, Behavioral and Social Sciences Research Enterprise, as defined in NOT-OD-20-031 (Notice of NIH's Interest in Diversity) category C under criteria 3, 4, and 5. The trainee will engage in the development of high- throughput data processing and analysis methodologies underlying research activities defined by grant R01MH120293, the goals of which are to elucidate mechanisms underlying working memory (WM) deficits in schizophrenia (SCZ) by identifying constituent cognitive functions comprised by WM (i.e., WM subconstructs) and neural correlates of their impairment in SCZ using Blood-Oxygen-Level-Dependent (BOLD) functional Magnetic Resonance Imaging (fMRI). This supplement will further support career engagement and educational opportunities by supporting national and international conference travel, through which the trainee will present their work and explore opportunities for integrated post-graduate research and clinical training in psychiatry, with networking support from the PI. The activities proposed in this supplement application will produce a rich multidisciplinary training experience in psychiatric neuroimaging and advance the objectives of the parent grant, with potential to produce a better understanding of WM deficits in SCZ and potential methods their treatment.

项目摘要 这是根据PA-21-071的行政补充的申请（研究补充 促进与健康相关的研究的多样性），以支持研究生阶段M.D./ph.d。双学位 生物医学工程的实习生源自美国生物医学中代表性不足的人群 临床，行为和社会科学研究企业，如NOT-OD-20-031（NIH的通知） 第3、4和5类对多元化的兴趣）C类 Grant定义的研究活动基础的吞吐量数据处理和分析方法 R01MH120293，其目标是阐明工作记忆的基础机制（WM）缺陷 精神分裂症（SCZ）通过识别由WM组成的成分认知功能（即WM子构造） 使用血氧级依赖性（BOLD）功能的SCZ损伤的神经相关性 磁共振成像（fMRI）。这种补充将进一步支持职业参与和教育 通过支持国家和国际会议旅行的机会，学员将通过该旅行 他们的工作和探索综合研究生研究和精神病学临床培训的机会， 在PI的网络支持下。此补充申请中提出的活动将产生富裕 精神神经影像学方面的多学科培训经验并促进父母的目标 授予，有潜力可以更好地了解SCZ中的WM缺陷和潜在方法 治疗。