Dysfunctional behavior with friends during middle childhood as a precursor to borderline personality pathology

童年中期与朋友的功能失调行为是边缘人格病理学的先兆

基本信息

批准号：
10806402
负责人：
Salome Vanwoerden
金额：
$ 17.62万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-05 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10806402
关键词：
Accounting Address Adolescence Affective Age Arousal Behavior Behavioral Borderline Personality Disorder Child Child Rearing Childhood Clinical Conflict (Psychology)Control Groups Cues Data Analyses Depressed mood Development Disease Early Intervention Early identification Emotional Etiology Exhibits Family Female Fostering Friends Friendships Functional disorder Gender Genetic Goals Hypersensitivity Institution Life Maternal Age Measurement Measures Mental Depression Mental disorders Mentors Methods Modeling Mother-Child Relations Mothers National Institute of Mental Health Parent-Child Relations Parents Pathology Patient Self-Report Pattern Personality Personality Traits Phase Phenotype Physiological Prevention Process Psychiatry Psychologist Psychopathology Psychophysiology Public Health Questionnaires Race Reporting Research Research Design Research Personnel Research Support Risk Specificity Strategic Planning Systems Theory Testing Time Training Universities Work Youth behavior observation comorbidity cost design dynamic system emotion dysregulation experience follow-up high risk human old age (65+)in vivo insight intergenerational intimate behavior middle childhood multimodality offspring peer preventive intervention programs response satisfaction severe mental illness social societal costs sociodemographic factors symptomatology teacher transmission process

项目摘要

PROJECT SUMMARY/ABSTRACT Borderline personality disorder (BPD) is a serious mental disorder associated with high cost that is transmitted intergenerationally. The interpersonal phenotype of BPD is characterized by hypersensitivity, hostile attribution bias, and maladaptive desire for exclusivity in relationships. Features of this phenotype can be identified in childhood and are associated with internalizing and externalizing pathology as well as later development of BPD. Aligned with the 2021 NIMH Strategic Plan, to identify malleable targets for prevention of psychopathology, it is necessary to study the unfolding of this critical mechanism prior to the onset of symptomatology. This proposal aims to do so among high-risk youth (based on maternal psychopathology) during middle childhood (ages 7-9; 50% female), a critical time for interpersonal development. This study measures the interpersonal features of BPD in the context of child-friend interactions to leverage multi-modal assessment and to focus on a central relationship of this developmental phase. Specific aims of the study are to 1) Test whether offspring of mothers with BPD (n=60) exhibit interpersonal features of BPD during middle childhood compared to offspring of mothers with depression (n=60) and non-disordered mothers (n=40); 2) Determine the extent to which BPD interpersonal features in middle childhood impede the development of friendship; and 3) Test associations between BPD interpersonal features and development of psychopathology in children. Friendship stability and quality and child psychopathology (internalizing, externalizing, BPD features) will be assessed at baseline and 6-months. The central hypothesis is that relative to controls, offspring of mothers with BPD are at highest risk of exhibiting interpersonal dysfunction that is specific to BPD during middle childhood. These behaviors have a negative effect on a central developmental milestone of middle childhood: fostering of closeness in friendship, which increases risk a range of psychopathology including BPD. The candidate, Dr. Vanwoerden, is a clinical psychologist seeking to transition to an independent research program focused on the early identification and prevention of BPD. This project is a first step toward this goal with a comprehensive training plan addressing the research questions while building on previous experiences in important ways. First, she will obtain training on the inclusion and assessment of children and friends in research. Second, she will focus on (dyadic) measurement and interpretation of electrodermal activity as a physiological marker of hypersensitivity. Third, she will gain proficiency in longitudinal research design, including retention of high-risk families and the analysis of data using methods aligned with dynamic systems theory. Drs. Stephanie Stepp, Amanda Rose, and Lauren Bylsma who have expertise in the developmental psychopathology of BPD, friendship processes, and psychophysiological assessment, respectively, will jointly mentor Dr. Vanwoerden. The research and training plan will be conducted at the University of Pittsburgh, Department of Psychiatry, a leading research institution with extensive research support, world class developmental psychopathology researchers, and state-of-the-art facilities.

项目概要/摘要边缘性人格障碍（BPD）是一种严重的精神障碍，其传播成本很高代际间。 BPD 的人际表现型以过敏、敌对归因为特征偏见和对关系中排他性的适应不良渴望。该表型的特征可以在童年时期，与内化和外化病理以及 BPD 的后期发展有关。与 2021 年 NIMH 战略计划保持一致，为了确定预防精神病理学的可塑目标，有必要在症状出现之前研究这一关键机制的展开。这个提议旨在针对儿童中期（7-9岁； 50%女性），是人际发展的关键时期。这项研究测量了人际交往特征在儿童与朋友互动的背景下，利用多模式评估并关注中心这一发展阶段的关系。该研究的具体目的是 1) 测试母亲的后代是否与母亲的后代相比，患有 BPD（n=60）的人在童年中期表现出 BPD 的人际特征患有抑郁症 (n=60) 和健康状况良好的母亲 (n=40)； 2) 确定 BPD 人际关系的程度童年中期的特征阻碍了友谊的发展； 3) 测试 BPD 之间的关联儿童的人际关系特征和精神病理学的发展。友谊稳定和质量与孩子精神病理学（内化、外化、BPD 特征）将在基线和 6 个月时进行评估。这中心假设是，相对于对照组，患有边缘性人格障碍的母亲的后代出现表现的风险最高童年中期 BPD 所特有的人际关系功能障碍。这些行为都会产生负面影响童年中期的一个中心发展里程碑：培养亲密的友谊，这会增加存在一系列精神病理学风险，包括 BPD。候选人 Vanwoerden 博士是一名临床心理学家寻求过渡到一个独立的研究计划，重点是早期识别和预防边缘性人格障碍。该项目是实现这一目标的第一步，它有一个针对研究的综合培训计划问题，同时以重要方式建立以前的经验。首先，她将接受包容性培训以及对研究中的儿童和朋友的评估。其次，她将专注于（二元）测量和将皮肤电活动解释为超敏反应的生理标志。第三，她将获得熟练掌握纵向研究设计，包括保留高风险家庭和使用数据进行分析与动态系统理论相一致的方法。博士。斯蒂芬妮·斯特普、阿曼达·罗斯和劳伦·拜尔斯玛拥有 BPD 发展精神病理学、友谊过程和心理生理学方面的专业知识分别进行评估将共同指导 Vanwoerden 博士。将进行研究和培训计划匹兹堡大学精神病学系是一家拥有广泛研究的领先研究机构支持、世界一流的发展精神病理学研究人员和最先进的设施。