COBRE in Digestive and Liver Diseases

COBRE 在消化系统和肝脏疾病中的应用

• 批准号: 10798819
• 负责人: STEPHEN A DUNCAN
• 金额: $ 24.93万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-03 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10798819
• 关键词: Animal Model; Award; Cell model; Cells; Centers of Research Excellence; Department chair; Development; Digestive System Disorders; Disease; Equipment; Evaluation; Funding; Gastrointestinal Diseases; Goals; Health; Human; Image; Institution; Interdisciplinary Study; Liver diseases; Medical; Medicine; Mentors; National Institute of Diabetes and Digestive and Kidney Diseases; Parents; Population; Research; Research Personnel; Resources; Source; South Carolina; Technology; Tissues; Treatment Cost; United States National Institutes of Health; Universities; burden of illness; college; cost estimate; design; improved; innovation; multidisciplinary; novel therapeutics; parent grant; programs; success

Abstract of Funded Parent Award The overall goal of the Center of Biomedical Research Excellence (COBRE) in Digestive & Liver Diseases (CDLD) is to enable outstanding multidisciplinary collaborative research in digestive and liver diseases at the Medical University of South Carolina. These diseases are of importance to the state of South Carolina because of the tremendous, disproportionate burden they have upon the state’s citizens. The specific aims are to: 1) Mentor an expanding cadre of successful Junior Investigators to become independently funded in digestive and liver disease research; 2) Develop innovative scientific core resources designed to stimulate and apply research discoveries in digestive and liver disease to improve human health; and 3) Sustain the CDLD and its long-term success through multidisciplinary research and programmatic evaluation and improvement strategies. The Center is led by a multidisciplinary team of two department chairs within the MUSC College of Medicine, coalescing resources to achieve their overarching objective of developing an NIDDK-funded Silvio O. Conte Digestive Disease Research Core Center at MUSC. Scientific cores include the: 1) Cell Models Core to generate advanced cell models of digestive and liver diseases; 2) Animal Models of Digestive Diseases Core to provide access to essential animal models; and 3) Advanced Imaging Core with sophisticated equipment, technologies and expertise required for successful, state-of-the-art cell and tissue-based imaging and analysis. This application highlights four Junior Investigators who will benefit from an innovative multiple source mentoring plan which features both internal and external mentors. With NIH and institutional support, the COBRE in Digestive & Liver Disease will facilitate the development of robust translational programs, ultimately leading to better mechanistic understanding with the potential for new therapeutic discoveries.

资助父母奖的摘要 消化和肝脏疾病中生物医学研究中心（COBRE）的总体目标 （CDLD）是为了在消化和肝脏疾病方面的出色多学科合作研究 南卡罗来纳州医科大学。这些疾病对南卡罗来纳州至关重要，因为 他们对国家公民的巨大，不成比例的伯恩。具体目的是：1） 指导一个不断扩大的成功初级调查人员的干部，以独立资金为消化和 肝病研究； 2）开发旨在刺激和应用研究的创新科学核心资源 消化和肝病的发现以改善人类健康； 3）维持CDLD及其长期 通过多学科研究以及程序化评估和改进策略取得成功。 中心由MUSC医学院的两个部门主席组成的多学科团队， 合并资源以实现他们开发NIDDK资助的Silvio O. Conte的总体目标。 MUSC的消化疾病研究核心中心。科学核心包括：1）生成细胞模型核心 消化和肝病的晚期细胞模型； 2）消化疾病核心的动物模型提供 获取基本动物模型； 3）具有复杂设备，技术的高级成像核心 以及成功，最先进的细胞和基于组织的成像和分析所需的专业知识。这 应用程序重点介绍了四名初级调查人员，他们将从创新的多重来源心理计划中受益 哪个具有内部和外部导师。在NIH和机构支持的情况下，消化的毛病 ＆肝病将有助于发展强大的转化计划，最终导致更好 机械理解，具有新的治疗发现的潜力。

项目成果

The cellular microenvironment and cytoskeletal actin dynamics in liver fibrogenesis.

• DOI: 10.32604/biocell.2022.020171
• 发表时间: 2022-05-18
• 期刊: Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al
• 作者: Hijazi N;Rockey DC;Shi Z
• 通讯作者: Shi Z

Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study.

• DOI: 10.1186/s40478-021-01226-2
• 发表时间: 2021-07-19
• 期刊: Acta neuropathologica communications
• 影响因子: 7.1
• 作者: Toutonji A;Mandava M;Guglietta S;Tomlinson S
• 通讯作者: Tomlinson S

Hemoglobin Monitoring in Acute Gastrointestinal Bleeding: Are We Monitoring Blood Counts Too Frequently?

• DOI: 10.1016/j.amjmed.2020.09.056
• 发表时间: 2021-05
• 期刊: The American journal of medicine
• 作者: Jaben I;Sasso R;Rockey DC
• 通讯作者: Rockey DC

Acute Liver Injury in Patients Hospitalized with COVID-19.

• DOI: 10.1007/s10620-021-07230-9
• 发表时间: 2022-08
• 期刊: Digestive diseases and sciences
• 影响因子: 3.1
• 作者: Sobotka LA;Esteban J;Volk ML;Elmunzer BJ;Rockey DC;North American Alliance for the Study of Digestive Manifestation of COVID-19*
• 通讯作者: North American Alliance for the Study of Digestive Manifestation of COVID-19*

Complement downregulation promotes an inflammatory signature that renders colorectal cancer susceptible to immunotherapy.

• DOI: 10.1136/jitc-2022-004717
• 发表时间: 2022-09
• 期刊: Journal for immunotherapy of cancer
• 影响因子: 10.9