Immune correlates of protection

保护的免疫相关性

• 批准号: 10712569
• 负责人: Richard A Koup
• 金额: $ 130.13万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10712569
• 关键词: Antigen Presentation; Antigen-Presenting Cells; Antigens; B-Lymphocytes; Chronic; Development; Disease Progression; Goals; HIV Infections; Immune; Immune response; Infection; Mediating; Pathway interactions; T cell response; T-Lymphocyte; Time; Vaccination; Vaccines; Viral Vaccines; Virus Diseases; clinical development; exhaustion; immune activation; lymph nodes; pathogen; vaccine development

We perform in depth analyses of the immune response to multiple different vaccines and to multiple different natural viral infections in order to dissect those immune responses that mediate protection from viral infection or dissemination. Antigen presenting cells are tracked from the time of vaccination to determine where and how they present antigen, and in what context, to B and T cells in the lymph nodes. The effects of chronic immune activation and antigen stimulation on the immune response to different pathogens are studied. In addition, the effects of HIV infection on different pathogen-specific T cell responses are evaluated.

我们深入分析了对多种不同疫苗的免疫反应和多种不同自然病毒感染的反应，以剖析介导免受病毒感染或传播保护的那些免疫反应。从疫苗接种时期，跟踪抗原呈递细胞，以确定它们在何处和如何呈现抗原，以及在什么情况下，到淋巴结中的B和T细胞。研究了慢性免疫激活和抗原刺激对对不同病原体的免疫反应的影响。另外，评估HIV感染对不同病原体特异性T细胞反应的影响。