Core Grant for Vision Research

视觉研究核心资助

基本信息

批准号：
10705644
负责人：
Patricia Ann D'Amore
金额：
$ 94.97万
依托单位：
SCHEPENS EYE RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-08-01 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10705644
关键词：
Anesthesia procedures Animal Experimentation Animal Experiments Animals Automobile Driving Biological Markers Breeding Cell Count Cells Code Collection Computer Systems Computer software Computers Confocal Microscopy Consult Consultations Core Grant Data Detection Development Electron Microscopy Eligibility Determination Equipment Eye Eye diseases Flow Cytometry Fluorescence Frozen Sections Funding Grant Histology Housing Human Resources Image Analysis Individual Instruction Investigation Laboratories Lasers Light Machine Learning Maintenance Measures Methacrylates Microdissection Microscope Microscopy Morphology Mus Operative Surgical Procedures Paraffin Pharmaceutical Preparations Phase Population Postoperative Care Principal Investigator Procedures Process Protocols documentation Research Research Institute Research Personnel Resource Sharing Resources Scanning Scanning Electron Microscopy Schedule Scientist Services Sorting Speed Supervision System Technical Expertise Techniques Technology Testing Tissues Training Transmission Electron Microscopy Vision Vision research Visual animal resource clinical examination computerized cryostat digital imaging epon experience image processing light microscopy monolayer mutant mouse model programs software development tissue preparation

项目摘要

Overall Core Project Summary/Abstract Funds are requested to support four modules that facilitate the research of and and enhance interaction among the investigators of at least 20 NEI-funded R01 grants. The modules will expand and enrich the activities of individual research programs by providing technologies and services not otherwise available to the investigators. The modules include Animal Resources, Flow Cytometry, Laboratory Computer Applications and Morphology. The Animal Resource Module provides expertise and assistance in animal surgical techniques and postoperative care, administration of anesthesia, drugs and medications. It includes the Animal Visual Assessment Core, which is a unique and valuable collection of equipment necessary for measuring murine vision as well as technical expertise for the training and/or conduct of particular assessments. It also provides specialized barrier services for the maintenance and breeding of unique mouse lines. The Flow Cytometry Module is a centralized service providing principal investigators and collaborators access to equipment and technical support for flow cytometry. The module offers cell counting, sorting to obtain viable populations of cells according to specific cellular markers, and biomarker detection. The Laboratory Computer Applications Module provides support to individual and collaborative efforts offering guidance in the application of machine learning, in the programming and developing software for gathering, processing, and in analyzing experimental data by computer systems. The module will also help projects involving image processing and analysis. The module interacts actively with the Animal, Flow Cytometry and Morphology Modules supporting analysis and export of data. The Morphology Module provides light, scanning and electron microscopy, confocal microscopy as well as tissue preparation and sectioning. The module houses and maintains shared equipment, and provides instruction on use of equipment, and makes protocols and techniques available to all. Personnel with specialized training in the respective fields and equipment staff the modules. Each module is under the immediate supervision of an established, experienced investigator. The department and organization are highly committed to keeping these resources robust, well-managed, technically up-to-date, and accessible to the investigators. Systems are in place to facilitate scheduling and to assure prioritization of P30-eligible R01s and young investigators.

总体核心项目摘要/摘要要求资金支持四个模块，以促进研究并增强互动至少20个NEI资助的R01补助金的研究人员。这些模块将扩展和丰富通过提供技术和服务的个人研究计划调查人员。这些模块包括动物资源，流式细胞仪，实验室计算机应用以及形态学。动物资源模块在动物外科手术技术方面提供了专业知识和帮助以及术后护理，麻醉，药物和药物的治疗。它包括动物视觉评估核心，这是测量鼠所需的独特且宝贵的设备集合视力以及技术专长，用于培训和/或进行特定评估。它也提供用于维护和繁殖独特小鼠线的专门障碍服务。流式细胞仪模块是一项集中式服务，为主要调查员和合作者提供了对设备的访问权限和流式细胞仪的技术支持。该模块提供细胞计数，分类以获得可行的人群根据特定的细胞标记和生物标志物检测。实验室计算机应用模块为个人和协作的努力提供了支持，该努力为机器的应用提供指导在编程和开发用于收集，处理和分析实验的软件中学习通过计算机系统数据。该模块还将帮助涉及图像处理和分析的项目。这模块与动物，流式细胞术和形态模块积极相互作用，支持分析和数据导出。形态模块提供光，扫描和电子显微镜，共聚焦显微镜以及组织制备和切片。该模块设有并维护共享设备，并且提供有关设备使用的说明，并为所有人提供协议和技术。人员各个领域和设备人员的专门培训模块。每个模块在立即监督已建立的，经验丰富的调查员。部门和组织高度致力于使这些资源保持强大，管理良好，技术上的最新状态，并可以访问调查人员。系统可以促进调度并确保P30合格R01的优先级和年轻的调查员。

项目成果

期刊论文数量（404）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Inter-Eye Association of Visual Field Defects in Glaucoma and Its Clinical Utility.

DOI：
10.1167/tvst.9.12.22
发表时间：
2020-11
期刊：
Translational vision science & technology
影响因子：
3
作者：
Teng B;Li D;Choi EY;Shen LQ;Pasquale LR;Boland MV;Ramulu P;Wellik SR;De Moraes CG;Myers JS;Yousefi S;Nguyen T;Fan Y;Wang H;Bex PJ;Elze T;Wang M
通讯作者：
Wang M

Extracellular Vesicles Secreted by Corneal Myofibroblasts Promote Corneal Epithelial Cell Migration.

DOI：
10.3390/ijms23063136
发表时间：
2022-03-15
期刊：
International journal of molecular sciences
影响因子：
5.6
作者：
Yeung V;Zhang TC;Yuan L;Parekh M;Cortinas JA;Delavogia E;Hutcheon AEK;Guo X;Ciolino JB
通讯作者：
Ciolino JB

One man's poison is another man's meat: using azithromycin-induced phospholipidosis to promote ocular surface health.

DOI：
10.1016/j.tox.2014.02.014
发表时间：
2014-06-05
期刊：
TOXICOLOGY
影响因子：
4.5
作者：
Liu, Yang;Kam, Wendy R.;Ding, Juan;Sullivan, David A.
通讯作者：
Sullivan, David A.

An Adjustable Magnetic Levator Prosthesis for Customizable Eyelid Reanimation in Severe Blepharoptosis II: Randomized Evaluation of Angular Translation.

DOI：
10.1167/tvst.12.12.1
发表时间：
2023-12-01
期刊：
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
影响因子：
3
作者：
Tirandazi, Pooyan;Nadeau, Melanie;Woods, Russell L.;Paschalis, Eleftherios I.;Houston, Kevin E.
通讯作者：
Houston, Kevin E.

Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure.