Estradiol Effects on Behavioral and Reward Sensitivity to Alcohol across the Menstrual Cycle

雌二醇对整个月经周期酒精行为和奖赏敏感性的影响

基本信息

批准号：
10687820
负责人：
Mark T Fillmore
金额：
$ 53.87万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-25 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10687820
关键词：
Acute Adverse effects Affect Alcohol abuse Alcohol consumption Alcohols Animal Experimentation Area Behavior Behavioral Behavioral Mechanisms Clinical assessments Consumption Data Data Reporting Disinhibition Dose Estradiol Estrogens Exhibits Female Grain Health Heavy Drinking Hormonal Hormones Impulsivity Intervention Investigation Laboratories Link Liver Cirrhosis Longitudinal Studies Maintenance Measures Menstrual cycle Neurobiology Oral Contraceptives Organ Ovarian hormone Ovulation Ovulation Prediction Patient Self-Report Pattern Periodicity Phase Physiological Placebos Progesterone Puberty Public Health Recording of previous events Relapse Research Rewards Risk Risk Taking Saliva Sampling Sex Behavior Sex Differences Substance abuse problem Testing Theoretical model Visit Woman Work abuse liability alcohol abuse therapy alcohol craving alcohol effect alcohol sensitivity alcohol use disorder binge drinking craving drinking behavior men neurobehavioral personalized intervention proliferative phase Menstrual cycle relapse prevention reproductive sexual assault theories university student young adult young woman

Acute Adverse effects Affect Alcohol abuse Alcohol consumption Alcohols Animal Experimentation Area Behavior Behavioral Behavioral Mechanisms Clinical assessments Consumption Data Data Reporting Disinhibition Dose Estradiol Estrogens Exhibits Female Grain Health Heavy Drinking Hormonal Hormones Impulsivity Intervention Investigation Laboratories Link Liver Cirrhosis Longitudinal Studies Maintenance Measures Menstrual cycle Neurobiology Oral Contraceptives Organ Ovarian hormone Ovulation Ovulation Prediction Patient Self-Report Pattern Periodicity Phase Physiological Placebos Progesterone Puberty Public Health Recording of previous events Relapse Research Rewards Risk Risk Taking Saliva Sampling Sex Behavior Sex Differences Substance abuse problem Testing Theoretical model Visit Woman Work abuse liability alcohol abuse therapy alcohol craving alcohol effect alcohol sensitivity alcohol use disorder binge drinking craving drinking behavior men neurobehavioral personalized intervention proliferative phase Menstrual cycle relapse prevention reproductive sexual assault theories university student young adult young woman

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项目摘要

PROJECT SUMMARY/ABSTRACT Alcohol use poses significant health problems particularly when characterized by bouts of heavy consumption (i.e., binges). It is now recognized that women demonstrate greater vulnerability to the adverse effects of alcohol, including greater physiological risk of organ damage (e.g., liver cirrhosis), than do men with comparable histories of alcohol use. Research suggests that ovarian hormones play a role in substance abuse. With regard to alcohol use, there is evidence to suggest that women may exhibit distinct patterns of heavy drinking across the menstrual cycle. Indeed, our preliminary research shows that surges in follicular estradiol [E2] at ovulation predict increased alcohol use in young women. Yet, to date no research has aimed to determine the specific behavioral mechanisms by which rapid surges in E2 confer increased abuse potential of alcohol. The proposed study directly examines ovarian hormone flux and acute sensitivity to alcohol to provide the first rigorous and integrative test of the hypothesis that rapid rises in estradiol increase the acute rewarding and disinhibiting effects of alcohol and that this heightened sensitivity increases alcohol use outside the laboratory. A sample of 100 naturally-cycling women will be examined daily over their menstrual cycle using an integrative combination of daily ecological assessments of hormone fluctuations and alcohol use along with strategically-timed laboratory tests of their acute sensitivity to the rewarding and disinhibiting effects of a controlled dose of alcohol. The findings will advance understanding of the neurobehavioral mechanisms linking E2 to alcohol abuse and inform clinical assessment practice by highlighting the importance of menstrual cycle phase and hormonal profiles when assessing alcohol abuse risk in young women.

项目摘要/摘要饮酒会带来重大的健康问题，特别是在大量消费的特征（即binges）。现在已经认识到，妇女表现出更大的脆弱性酒精，包括器官损伤的生理风险更大（例如肝肝硬化），比患有可比较的酒精使用历史。研究表明，卵巢激素在药物滥用中起作用。关于饮酒，有证据表明妇女可能表现出不同的重量模式在月经周期中喝酒。确实，我们的初步研究表明，卵泡雌二醇激增 [E2]排卵预测年轻女性的酒精使用量增加。然而，迄今为止，没有任何研究旨在确定特定的行为机制，通过这些机制，E2中快速涌现的滥用潜力提高了酒精。拟议的研究直接检查了卵巢激素通量和对酒精的急性敏感性雌二醇快速上升的假设的第一个严格和综合测试增加了急性奖励并消除酒精的抑制作用，并且这种提高的敏感性会增加酒精的用途实验室。每天将在月经周期中检查100个自然循环妇女的样本激素波动和饮酒的日常生态评估以及使用的综合组合以及战略性地定时实验室测试其对奖励和消除抑制作用的急性敏感性受控剂量的酒精。这些发现将提高对神经行为机制的理解通过强调月经的重要性，将E2链接到酗酒并为临床评估实践提供信息评估年轻妇女的酗酒风险时，周期阶段和荷尔蒙特征。