Attention-based neural response to threat moderates the expression of BI

基于注意力的神经对威胁的反应调节 BI 的表达

基本信息

批准号：
10686227
负责人：
Caroline M. Kelsey
金额：
$ 7.18万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10686227
关键词：
3 year old 5 year old Affective Age Months American Anger Anxiety Anxiety Disorders Area Attention Behavior Behavioral Behavioral Paradigm Behavioral inhibition Boston Brain Child Behavior Checklist Childhood Cognitive Cues Data Development Diagnostic Disease Distress Early Intervention Early identification Emotional Emotions Eye Face Facial Expression Grant Happiness Individual Individual Differences Infant Infant Behavior Intervention Investigation Knowledge Life Life Cycle Stages Link Longevity Longitudinal Studies Maps Measures Mental Health Mentorship Methodology Modality Modification Neurocognitive Outcome Parietal Lobe Pattern Pediatric Hospitals Peripheral Persons Physiology Positioning Attribute Prefrontal Cortex Process Public Health Questionnaires Reporting Research Research Project Grants Resolution Risk Risk Marker Secure Severities Shapes Social Anxiety Disorder Stimulus Temporal Lobe Testing Time Toddler Training Universities Work anxiety symptoms attentional bias attentional modulation childhood anxiety cognitive neuroscience early childhood functional near infrared spectroscopy gaze improved infancy insight longitudinal dataset medical schools meetings multimodality neural novel response social tenure track trait visual tracking

项目摘要

Project Summary/Abstract Research Project: Behavioral Inhibition (BI) is a behavioral trait marked by enhanced discomfort during novel situations, such as going to a new place or meeting a new person. Though BI has been recognized as one of the strongest early indicators of social anxiety disorders later in childhood, many toddlers with BI do not go onto develop an internalizing disorder. To better understand the multiple outcomes of this risk marker the present study leverages a large (N = 326) pre-established longitudinal study to examine the underlying cognitive and neural processes of BI, specifically aberrant threat responding. To this end, I will assess the relation between BI (assessed at infancy and toddlerhood) and anxiety symptoms (assessed at 3 and 5 years of age; aim 1). Next, I will determine the link between attention- based neural response to threat and anxiety symptoms using a simultaneous functional Near- Infrared Spectroscopy (fNIRS) and eye tracking paradigm (aim 2). Finally, I will examine if and how individual differences in attention based neural responding moderates the expression of BI to predict childhood anxiety symptomology (aim 3). This investigation is of great relevance to public health because approximately one in three Americans will develop an anxiety disorder during their lifetime. Therefore, understanding core processes prior to and during the time when symptoms of anxiety disorders first emerge provides a tractable approach to disrupting anxiety trajectories across the lifespan. Training: The unparalleled training and mentorship provided by Sponsor Nelson (expert in developmental cognitive neuroscience) and Co-Sponsor Bosquet Enlow (expert in childhood anxiety disorders) at Boston Children’s Hospital/Harvard Medical school will bolster my methodological and theoretical knowledge in order to best prepare me to secure and successfully carryout a tenure track position at a research university.

项目摘要/摘要研究项目：行为抑制（BI）是一种行为特征，标志着增强在新颖的情况下，例如去新地方或结识新人的不适。尽管BI被公认为是社交动画的更强的早期指标之一童年后期的疾病，许多具有BI的幼儿不会开发内部化紊乱。为了更好地了解此风险标记的多重结果本研究利用大型（n = 326）预先建立的纵向研究来检查基础 BI的认知和神经过程，特别是异常威胁作出反应。为此，我会评估BI（在婴儿期和幼儿时评估）和焦虑符号之间的关系（在3岁和5岁时评估；目标1）。接下来，我将确定注意力 - 基于对威胁和焦虑症状的神经反应，使用简单的功能接近红外光谱（FNIRS）和眼睛跟踪范式（AIM 2）。最后，我将检查是否和基于注意力的神经反应中的个体差异如何缓和BI的表达预测儿童动画症状（AIM 3）。这项投资与公共卫生是因为大约三分之一的美国人会发展出焦虑症在他们的一生中。因此，在之前和期间了解核心过程动画障碍的症状首先出现，提供了一种可破坏动画的方法整个生命周期的轨迹。培训：赞助商纳尔逊（Nelson）提供的无与伦比的培训和精神训练（专家发展性认知神经科学）和共同赞助者Bosquet Enlow（童年专家焦虑症）波士顿儿童医院/哈佛医学院将加强我的方法论和理论知识以最好地为我做好准备，并成功地在一所研究大学担任终身轨道职位。