Dietary intake, inflammation,glycemia, & BP in T2 Diabetes: Examining disparities

饮食摄入、炎症、血糖、

基本信息

批准号：
8716323
负责人：
Sarah Yancey Nowlin
金额：
$ 3.51万
依托单位：
NEW YORK UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-01 至 2015-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8716323
关键词：
20 year old Address Adult Affect Age American Anti-Inflammatory Agents Anti-inflammatory Attenuated Biological Markers Blood Pressure C-reactive protein Cardiovascular system Caring Centers for Disease Control and Prevention (U.S.)Cessation of life Chronic Data Data Analyses Development Diabetes Mellitus Diagnosis Diet Dietary Assessment Dietary Fiber Dietary Intervention Dietary Practices Dietary intake Disease Eating Elderly Epidemic Ethnic Origin Ethnic group Etiology Fatty acid glycerol esters Fishes Food Food Patterns Foundations Functional disorder Future Glucose Glycosylated Hemoglobin Glycosylated hemoglobin A Grouping Guidelines Health Healthy People 2020 High Prevalence Hispanics Hour Hyperglycemia Hypertension Individual Inflammation Inflammatory Instruction Insulin Resistance Intake Intervention Knowledge Life Expectancy Literature Measures Mediating Mediation Medical Nutrition Therapy Mediterranean Diet Metabolic Metabolic Diseases Minority Minority Groups Modeling National Health and Nutrition Examination Survey Non-Insulin-Dependent Diabetes Mellitus Not Hispanic or Latino Nutrient Obesity Olive oil preparation Outcome Participant Pattern Persons Population Population Heterogeneity Prediabetes syndrome Prevalence Prevention Property Proteins Race Recommendation Reporting Research Risk Factors System Testing United States cost cytokine density diabetes management diabetes prevention program diet and exercise fruits and vegetables glycemic control health disparity human old age (65+)improved indexing inflammatory marker insight lifestyle intervention meetings mortality prevent public health relevance racial and ethnic racial/ethnic difference research study

项目摘要

DESCRIPTION (provided by applicant): Diabetes is a growing epidemic in the U.S., related in part to the poor quality of dietary intake patterns of Americans. Hispanics and non-Hispanic Blacks have higher prevalence of type 2 diabetes (T2D), and have been found to have poorer diet quality than non-Hispanic Whites. Elevated markers of inflammation, poorer glycemic control, and higher blood pressure have also been observed in minority populations when compared to non-Hispanic Whites. Higher levels of these biomarkers are independently associated with increased all- cause mortality and other poor health outcomes. T2D is an inflammatory and metabolic disease, as hyperglycemia related to insulin resistance causes increases in inflammatory markers. Associations between blood pressure (BP) and inflammation are also appearing in the literature, but little is known about these associations in T2D. Research has suggested that dietary intake may affect inflammation and glycemia, and the Mediterranean diet has been shown to decrease C-reactive protein (CRP) and glycated hemoglobin (HbA1c). Similarly, the USDA Food Guidelines for Americans have also been associated with improved biomarkers. The associations between dietary intake patterns, inflammation, glycemic control, and BP in T2D have not been examined comprehensively in relation to race and ethnicity. The proposed research study is a secondary analysis of data collected from NHANES 2009-2010. Dietary assessment through 24-hour recall among adults with and without T2D will provide data to create Mediterranean Diet (MSDPS) and Healthy Eating Index (HEI) Scores, and the relation between these scores and CRP, HbA1c, and BP will be examined. Race and ethnicity will be examined as the grouping variable, as the disparity in health outcomes across race/ethnicity is what this study aims to explain. Specifically, the aims of the proposed research are to 1) examine the direct and indirect effects between race/ethnicity and CRP, HbA1c, and BP as mediated by dietary pattern score (measured by the MSDPS and HEI scores), and BMI; and 2) explore whether the indirect effects of race/ethnicity to CRP, HbA1c, and BP, as mediated by dietary intake pattern (measured by the MSDPS and HEI scores) and BMI, are moderated by T2D status. The findings from this study will provide insight into the associations between dietary intake patterns and health outcomes, and demonstrate how they differ between racial and ethnic groups. This study will contribute to knowledge regarding the association between diet and health outcomes, and provide the foundation for the development of future experimental research examining dietary interventions in multiethnic populations in relation to health outcomes.

描述（由申请人提供）：糖尿病在美国是一种日益流行的疾病，部分原因是美国人的饮食摄入模式质量差。西班牙裔和非西班牙裔黑人的 2 型糖尿病 (T2D) 患病率较高，并且饮食质量比非西班牙裔白人较差。与非西班牙裔白人相比，少数族裔人群的炎症标志物升高、血糖控制较差和血压升高。这些生物标志物水平较高与全因死亡率增加和其他不良健康结果独立相关。 T2D 是一种炎症和代谢疾病，因为与胰岛素抵抗相关的高血糖会导致炎症标志物增加。血压 (BP) 和炎症之间的关联也出现在文献中，但人们对 T2D 中的这些关联知之甚少。研究表明，饮食摄入可能会影响炎症和血糖，地中海饮食已被证明可以降低 C 反应蛋白 (CRP) 和糖化血红蛋白 (HbA1c)。同样，美国农业部的美国人食品指南也与改进的生物标志物相关。 T2D 中膳食摄入模式、炎症、血糖控制和血压之间的关联尚未与种族和民族进行全面研究。拟议的研究是对 2009-2010 年 NHANES 收集的数据进行的二次分析。通过对患有和未患有 T2D 的成年人进行 24 小时回忆进行饮食评估，将提供数据来创建地中海饮食 (MSDPS) 和健康饮食指数 (HEI) 分数，并将检查这些分数与 CRP、HbA1c 和 BP 之间的关系。种族和族裔将作为分组变量进行检查，因为本研究旨在解释不同种族/族裔之间健康结果的差异。具体来说，拟议研究的目的是 1) 检查种族/族裔与 CRP、HbA1c 和 BP 之间由饮食模式评分（通过 MSDPS 和 HEI 评分测量）和 BMI 介导的直接和间接影响； 2) 探讨饮食摄入模式（通过 MSDPS 和 HEI 评分测量）和 BMI 介导的种族/民族对 CRP、HbA1c 和 BP 的间接影响是否受到 T2D 状态的调节。这项研究的结果将深入了解饮食摄入模式与健康结果之间的关联，并展示它们在种族和民族群体之间的差异。这项研究将有助于了解饮食与健康结果之间的关系，并为未来检验多种族人群饮食干预与健康结果关系的实验研究的发展奠定基础。