Research and mentoring on cognitive neuroscience and high-field MRI of the thalamus in schizophrenia

精神分裂症认知神经科学和丘脑高场 MRI 的研究和指导

• 批准号: 10686989
• 负责人: Neil D. Woodward
• 金额: $ 14.93万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686989
• 关键词: Address; Anatomy; Animals; Anterior; Area; Behavioral; Brain; Caregiver Burden; Cell Nucleus; Characteristics; Cognition; Cognitive; Data; Data Set; Disease; Doctor of Philosophy; Electrophysiology (science); Faculty; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Future; Geniculate body structure; Human; Image; Impaired cognition; Impairment; Individual; Knowledge; Lateral; Lesion; Link; MRI Scans; Magnetic Resonance Imaging; Medial Dorsal Nucleus; Medical; Medical Students; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Modeling; Neuropsychology; Neurosciences; Outcome; Pathology; Patient Education; Phenotype; Postdoctoral Fellow; Prefrontal Cortex; Process; Property; Psychopathology; Psychoses; Psychotic Disorders; Pulvinar structure; Research; Schizophrenia; Science; Structural defect; Structure; Structure/Function Nuclei; Testing; Thalamic Nuclei; Thalamic structure; Time; Training; Translating; Visualization; Work; attentional control; cognitive development; cognitive neuroscience; economic cost; experience; flexibility; graduate student; human imaging; imaging modality; improved; in vivo; network models; neural; neuroimaging; novel; patient oriented research; programs; psychosocial; public health relevance; skills; support network; white matter; Address; Anatomy; Animals; Anterior; Area; Behavioral; Brain; Caregiver Burden; Cell Nucleus; Characteristics; Cognition; Cognitive; Data; Data Set; Disease; Doctor of Philosophy; Electrophysiology (science); Faculty; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Future; Geniculate body structure; Human; Image; Impaired cognition; Impairment; Individual; Knowledge; Lateral; Lesion; Link; MRI Scans; Magnetic Resonance Imaging; Medial Dorsal Nucleus; Medical; Medical Students; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Modeling; Neuropsychology; Neurosciences; Outcome; Pathology; Patient Education; Phenotype; Postdoctoral Fellow; Prefrontal Cortex; Process; Property; Psychopathology; Psychoses; Psychotic Disorders; Pulvinar structure; Research; Schizophrenia; Science; Structural defect; Structure; Structure/Function Nuclei; Testing; Thalamic Nuclei; Thalamic structure; Time; Training; Translating; Visualization; Work; attentional control; cognitive development; cognitive neuroscience; economic cost; experience; flexibility; graduate student; human imaging; imaging modality; improved; in vivo; network models; neural; neuroimaging; novel; patient oriented research; programs; psychosocial; public health relevance; skills; support network; white matter

ABSTRACT A K24 Mid-Career Investigator Award in Patient-Oriented Research (POR) is requested to: 1) augment my capabilities in POR to include new expertise in network science, and the cognitive neuroscience and neuroimaging of the human thalamus; 2) apply these new expertise to perform novel studies of thalamic connectivity, function, and structure in psychotic disorders; and 3) enhance my mentorship skills and provide protected time to mentor trainees. My research program investigating the neural basis of psychotic disorders serves as a platform for training POR trainees. This includes mentoring junior faculty, postdoctoral fellows, graduate students, and MD/PhD medical students in psychotic disorders, neuroimaging, and neuropsychology. For the past several years my lab has focused on investigating thalamocortical circuit abnormalities in psychotic disorders. We were among the first to show that functional connectivity of the thalamus in schizophrenia is characterized by a combination of lower connectivity with the prefrontal cortex (PFC) and hyper-connectivity with sensorimotor cortical areas. Our findings coincided with groundbreaking discoveries in the cognitive neuroscience of the thalamus. However, many recent advances in the fundamental neuroscience of the thalamus have yet to translate to improved understanding of the mechanisms of psychosis phenotypes. This translational gap is impeding progress in identifying potential treatment targets for cognitive impairment. Progress is further hindered by limitations of conventional neuroimaging methods which are unable to directly visualize individual thalamic nuclei in humans. This proposal provides the foundation for addressing these challenges. Specifically, I will develop new research skills in network science (Aim 1) and the cognitive neuroscience of the thalamus (Aim 2A), extend existing expertise in neuroimaging to include state-of-the-art methods for imaging the human thalamus in vivo (Aim 2B), and apply these new expertise to characterize thalamic nuclei structure and function abnormalities in early stage schizophrenia (Aim 3). This proposal will: 1) enhance ongoing work in my lab characterizing brain connectivity in psychopathology and normal cognitive development; and 2) provide me with critical expertise required for future studies focused on informing thalamocortical mechanisms of psychosis phenotypes.

抽象的 请求：1）增强我的K24中级研究员奖（POR） POR的能力包括网络科学领域的新专业知识，以及认知神经科学和 人丘脑的神经影像学； 2）应用这些新专业知识来进行丘脑的新研究 精神病的连通性，功能和结构； 3）提高我的指导能力并提供 保护了指导学员的时间。我的研究计划调查了精神病的神经基础 是培训POR受训者的平台。这包括指导初级教师，博士后研究员， 研究生，以及神经影像学和神经心理学的医学博士/博士学位学生。 在过去的几年中 精神病。我们是第一个表明丘脑功能连接性的人之一 精神分裂症的特征是较低的连通性与前额叶皮层（PFC）和 与感觉运动皮质区域的高度连接性。我们的发现与开创性的发现相吻合 丘脑的认知神经科学。但是，基本神经科学的最新进展 丘脑尚未转化为改善对精神病表型机制的理解。 这种翻译差距在识别潜在的认知障碍治疗靶标方面阻碍了进步。 传统神经影像学方法的局限性进一步阻碍了进步 可视化人类的单个丘脑核。该建议为解决这些问题提供了基础 挑战。具体来说，我将发展网络科学方面的新研究技能（AIM 1）和认知能力 丘脑神经科学（AIM 2A），扩展了现有的神经影像学专业知识 在体内成像人类丘脑的方法（AIM 2B），并将这些新专业知识应用于表征 早期精神分裂症的丘脑核结构和功能异常（AIM 3）。该提议将：1） 增强我的实验室中正在进行的工作，表征精神病理学和正常认知的大脑连通性 发展; 2）为我提供未来研究所需的关键专业知识，专注于告知 精神病表型的丘脑皮质机制。