Validation of a novel measurement battery of relationship and safety skills for adults with and without autism spectrum disorder

验证患有和不患有自闭症谱系障碍的成年人的关系和安全技能的新型测量组合

• 批准号: 10687234
• 负责人: Eileen Tara Crehan
• 金额: $ 24.58万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-20 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10687234
• 关键词: Adult; Age; Assessment tool; Attention deficit hyperactivity disorder; Behavior; Behavior Therapy; Behavioral; Clinical; Clinical Trials; Cognitive; Communication; Comprehension; Control Groups; Development; Diagnosis; Emotional; Employment; Evaluation; Eye Movements; Feeling; Forcible intercourse; Friendships; Future; Health; Health Services Research; Heart Rate; Housing; Individual; Intellectual functioning disability; Internet; Intervention; Intervention Trial; Legal; Length; Life; Link; Loneliness; Measurement; Measures; Mental Health; Needs Assessment; Outcome; Outcome Measure; Participant; Patient Self-Report; Performance; Physiological; Pilot Projects; Population; Privatization; Protocols documentation; Psychophysiology; Questionnaires; Research Personnel; Risk; Safety; Schizophrenia; Severities; Sex Functioning; Sexual Health; Sexual abuse; Sexuality; Social Functioning; Symptoms; Time; Validation; Victimization; Work; adult with autism spectrum disorder; autism spectrum disorder; behavioral response; cognitive interview; cohort; cost; disorder control; effectiveness study; efficacy study; experience; feasibility testing; follow up assessment; improved; individuals with autism spectrum disorder; insight; instrument; interest; intervention program; novel; peer; response; service intervention; sex; sexual relationship; sexual victimization; skills; social; social anxiety; social skills; standardize measure; tool; trustworthiness; verbal; visual tracking

In this study, we seek to improve assessment of critical safety and relationship skill domains by developing and validating a novel measurement battery. Sensitive and objective tools that assess these domains are extremely limited. This lack of established measurement tools poses a critical challenge to studies of the efficacy and effectiveness of important safety interventions and relationship skill protocols, especially for populations uniquely vulnerable to negative outcomes, such as adults on the autism spectrum (AA). The financial, emotional, and physical costs of failing to adequately prepare individuals to navigate relationships safely and effectively has been demonstrated across many diagnoses. Effectively measuring related behaviors—such as navigating public/private boundaries, recognizing when others are interested in a relationship, determining the trustworthiness of potential partners, judging situations for safety, using indirect communication, and taking the perspective of others—is a critical task needed to accurately characterize the challenges of AA and other adults with social difficulties and to track progress both over time and in response to adult social skills interventions. We propose a battery of performance-based tools that target these skill domains via behavioral, eye tracking, and psychophysiological responses to social information. The strength of this battery is the objectivity of the chosen tools (e.g., behavioral responses, tracking eye movements, and heart rate) and their ecological validity (i.e., mimicking everyday experiences such as using the internet, navigating dating apps, and engaging in various types of relationships). The total length of the proposed project is three years. The measurement battery will be presented at two time points (3 months apart) to a total of 200 adults (100 AA, 100 adults without autism). We have three aims: (1) To examine the feasibility of acquisition of the proposed measures for AA; (2) To assess the utility of the measurement battery for assessing social difficulties of the AA and non-ASD groups, and (3) To validate the measures for use in clinical trials by examining (3a) their short term stability, (3b) convergent validity with a measure of general social functioning, and (3c) demonstrate their utility as measures of target engagement by confirming their correlation to outcome measures of romantic and sexual functioning. Achieving these aims will provide a novel toolkit for investigators to use to measure social cognitive, behavioral, and physiological changes in response to intervention programs for AA and, ultimately, populations with similar safety and relationship skills deficits (e.g., intellectual disability, ADHD, social anxiety, schizophrenia).

在这项研究中，我们试图通过开发和 验证新型测量电池。评估这些领域的敏感和客观工具非常 有限的。缺乏既定的测量工具对研究效率的研究构成了关键挑战 重要的安全干预措施和关系技能方案的有效性，尤其是对于人口的独特性 容易受到负面结果的影响，例如自闭症谱系上的成年人（AA）。财务，情感和 未能充分准备个人以安全有效地导航人际关系的身体成本 在许多诊断中得到了证明。有效测量相关行为（例如导航） 公共/私人边界，认识到他人何时对关系感兴趣，确定 潜在合作伙伴的可信赖性，以安全性来判断情况，使用间接沟通并接受 他人的观点是准确表征AA和其他成年人挑战所需的关键任务 遇到社会困难，并随着时间的流逝以及对成人社交技能干预的回应跟踪进步。 我们提出了一系列基于性能的工具，该工具通过行为，眼睛跟踪，针对这些技能域 和心理生理对社会信息的反应。电池的强度是 选择工具（例如，行为反应，跟踪眼动和心率）及其生态有效性 （即，模仿每天的经验，例如使用互联网，浏览约会应用并参与各种 关系类型）。拟议项目的总长度为三年。测量电池将是 在两个时间点（相隔3个月）出现，总计200名成年人（100名AA，100名没有自闭症的成年人）。我们 有三个目标：（1）检查拟议的AA措施的可行性； （2）评估 测量电池用于评估AA和非ASD组的社会困难的实用性，以及（3） 通过检查（3a）其短期稳定性，（3B）收敛有效性来验证用于临床试验的测量值 通过测量一般社会功能，（3C）证明了它们的实用性作为目标参与度的测量 通过确认它们与浪漫和性功能的结果度量的相关性。实现这些目标 将为调查人员提供一个新颖的工具包，以衡量社会认知，行为和生理学 响应于AA的干预计划以及最终具有相似安全性和的人群的变化 关系技能缺陷（例如，智力残疾，多动症，社交焦虑，精神分裂症）。