Validation of a novel measurement battery of relationship and safety skills for adults with and without autism spectrum disorder

验证患有和不患有自闭症谱系障碍的成年人的关系和安全技能的新型测量组合

• 批准号: 10687234
• 负责人: Eileen Tara Crehan
• 金额: $ 24.58万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-20 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10687234
• 关键词: Adult; Age; Assessment tool; Attention deficit hyperactivity disorder; Behavior; Behavior Therapy; Behavioral; Clinical; Clinical Trials; Cognitive; Communication; Comprehension; Control Groups; Development; Diagnosis; Emotional; Employment; Evaluation; Eye Movements; Feeling; Forcible intercourse; Friendships; Future; Health; Health Services Research; Heart Rate; Housing; Individual; Intellectual functioning disability; Internet; Intervention; Intervention Trial; Legal; Length; Life; Link; Loneliness; Measurement; Measures; Mental Health; Needs Assessment; Outcome; Outcome Measure; Participant; Patient Self-Report; Performance; Physiological; Pilot Projects; Population; Privatization; Protocols documentation; Psychophysiology; Questionnaires; Research Personnel; Risk; Safety; Schizophrenia; Severities; Sex Functioning; Sexual Health; Sexual abuse; Sexuality; Social Functioning; Symptoms; Time; Validation; Victimization; Work; adult with autism spectrum disorder; autism spectrum disorder; behavioral response; cognitive interview; cohort; cost; disorder control; effectiveness study; efficacy study; experience; feasibility testing; follow up assessment; improved; individuals with autism spectrum disorder; insight; instrument; interest; intervention program; novel; peer; response; service intervention; sex; sexual relationship; sexual victimization; skills; social; social anxiety; social skills; standardize measure; tool; trustworthiness; verbal; visual tracking

In this study, we seek to improve assessment of critical safety and relationship skill domains by developing and validating a novel measurement battery. Sensitive and objective tools that assess these domains are extremely limited. This lack of established measurement tools poses a critical challenge to studies of the efficacy and effectiveness of important safety interventions and relationship skill protocols, especially for populations uniquely vulnerable to negative outcomes, such as adults on the autism spectrum (AA). The financial, emotional, and physical costs of failing to adequately prepare individuals to navigate relationships safely and effectively has been demonstrated across many diagnoses. Effectively measuring related behaviors—such as navigating public/private boundaries, recognizing when others are interested in a relationship, determining the trustworthiness of potential partners, judging situations for safety, using indirect communication, and taking the perspective of others—is a critical task needed to accurately characterize the challenges of AA and other adults with social difficulties and to track progress both over time and in response to adult social skills interventions. We propose a battery of performance-based tools that target these skill domains via behavioral, eye tracking, and psychophysiological responses to social information. The strength of this battery is the objectivity of the chosen tools (e.g., behavioral responses, tracking eye movements, and heart rate) and their ecological validity (i.e., mimicking everyday experiences such as using the internet, navigating dating apps, and engaging in various types of relationships). The total length of the proposed project is three years. The measurement battery will be presented at two time points (3 months apart) to a total of 200 adults (100 AA, 100 adults without autism). We have three aims: (1) To examine the feasibility of acquisition of the proposed measures for AA; (2) To assess the utility of the measurement battery for assessing social difficulties of the AA and non-ASD groups, and (3) To validate the measures for use in clinical trials by examining (3a) their short term stability, (3b) convergent validity with a measure of general social functioning, and (3c) demonstrate their utility as measures of target engagement by confirming their correlation to outcome measures of romantic and sexual functioning. Achieving these aims will provide a novel toolkit for investigators to use to measure social cognitive, behavioral, and physiological changes in response to intervention programs for AA and, ultimately, populations with similar safety and relationship skills deficits (e.g., intellectual disability, ADHD, social anxiety, schizophrenia).

在这项研究中，我们寻求通过开发和改进关键安全和关系技能领域的评估 验证评估这些领域的新型测量工具非常敏感和客观。 缺乏既定的测量工具对功效和作用的研究提出了严峻的挑战。 重要安全干预措施和关系技能协议的有效性，特别是对于独特的人群 容易受到负面结果的影响，例如患有自闭症谱系 (AA) 的成年人。 未能让个人做好充分准备以安全有效地驾驭关系所带来的身体成本 已在许多诊断中得到证明，可以有效地测量相关行为，例如导航。 公共/私人界限，识别其他人何时对某种关系感兴趣，确定 潜在合作伙伴的可信度、判断安全情况、使用间接沟通并采取措施 他人的观点——是准确描述 AA 和其他成年人面临的挑战所需的一项关键任务 与社会困难，并跟踪随着时间的推移和对成人社会干预的反应的进展。 我们提出了一系列基于绩效的工具，通过行为、眼球追踪、 以及对社会信息的心理生理反应。这种电池的力量在于其客观性。 选择的工具（例如行为反应、跟踪眼球运动和心率）及其生态有效性 （即模仿日常体验，例如使用互联网、浏览约会应用程序以及参与各种活动 关系类型）。拟议项目的总长度为三年。 在两个时间点（相隔 3 个月）向总共 200 名成年人（100 名 AA，100 名没有自闭症的成年人）进行了演示。 目标有三个： (1) 审查实施建议的 AA 措施的可行性； (2) 评估 测量组在评估 AA 和非 ASD 群体的社交困难方面的效用，以及 (3) 通过检查 (3a) 短期稳定性、(3b) 收敛有效性来验证临床试验中使用的措施 衡量一般社会功能，并且 (3c) 展示其作为目标参与度衡量标准的效用 通过确认它们与浪漫和性功能结果测量的相关性来实现这些目标。 将为研究人员提供一个新颖的工具包，用于测量社会认知、行为和生理 AA 干预计划的变化，以及最终具有相似安全性和安全性的人群 人际关系技能缺陷（例如智力障碍、多动症、社交焦虑、精神分裂症）。