Impacts of modifiable factors on personal exposures and acute health

可改变因素对个人暴露和急性健康的影响

• 批准号: 10681462
• 负责人: Misti Levy Zamora
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-10 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10681462
• 关键词: Acute; Air; Air Pollutants; Air Pollution; Area; Aromatic Polycyclic Hydrocarbons; Automobile Driving; Baltimore; Benzene; Bicycling; Biological; Biological Availability; Biological Markers; Blood Pressure; Carbon Dioxide; Cardiovascular system; Chemicals; Cities; Commuting; Complement; Data; Dose; Emerging Technologies; Environmental Health; Epidemiologist; Exercise; Exposure to; Forced expiratory volume function; Funding; Goals; Health; Health Benefit; Hour; Individual; Infrastructure; Intervention Studies; Knowledge; Life Style; Location; Measurable; Measurement; Measures; Mentors; Methods; Minor; Monitor; Nitrogen Dioxide; Noise; Oxidative Stress; Ozone; Participant; Particulate Matter; Patient Recruitments; Personal Behavior; Persons; Phase; Physical activity; Pollution; Positioning Attribute; Publishing; Pulmonary Inflammation; Pulse Pressure; Reporting; Research; Research Personnel; Resources; Respiration; Route; Sampling; Scientist; Severities; Silicones; Time; Toluene; Transportation; Travel; Vital capacity; Walking; Work; Workplace; Xylene; ambient air pollution; cohort; dosimetry; ethylbenzene; improved; member; metropolitan; mortality; novel; oxidative DNA damage; pollutant; recruit; respiratory; skills; systemic inflammatory response; toxicant; traffic-related air pollution; urinary

Project Summary My long-term goal is to identify how individuals can mitigate exposures to the deleterious health effects of air pollution through practical lifestyle adjustments. My primary project objective is to investigate how an individual's choices influence personal exposures to traffic-related air pollutants (TRAP) and the corresponding acute health effects. It has been reported that traffic pollutants may cause up to half of all air pollution related mortalities. Despite the burden from such widespread, involuntary exposures, few studies have examined the magnitude of personal exposures due to commuting exposures. A commuter's exposure is dependent on the mode of transport, time of day, route, and fuel type. Public transportation, bicycling, and walking have been promoted as ways to reduce air pollution by reducing the vehicle fleet, yet few studies have examined how exposures would be modified due to a change in the mode of transportation or the subsequent health effects. In this study, 65 participants will be asked to utilize two modes of transportation (car and either bicycle, rail, or bus) during their typical commute over 4 days (two days per mode). During each 24-hr period, the participants will be examined for changes in oxidative stress biomarkers and acute cardiovascular and respiratory endpoints and 7+ pollutants and noise levels will be quantified in real-time. I hypothesize that there will be a significant association between exposure levels and acute health endpoints. An examination will be conducted into whether this association is modified by mode of transport. I will also examine the influence of the time of day an individual chooses to commute to work and exercise outdoors in a second cohort of 75 participants. Since TRAP tends to be most concentrated during two relatively short periods of time (morning and evening rush hours), I hypothesize that altering the time of exposure will notably change personal exposures. This project will bring in a key components of the personal exposure paradigm, an individual's decision- induced reductions in exposure. We will identify modifiable factors/personal choices that can reduce exposures with the objective of identifying which reductions in exposure can lead to meaningful health benefits. This knowledge will enable individuals to make lifestyle choices that can reduce their exposure independent of the ambient air quality or regulatory changes. This will be particularly beneficial in the study location (Baltimore), where the combustion-related mortality rate is highest in the U.S. It is expected that the information obtained in this K99/R00 will be applicable to other metropolitan areas with similar infrastructure. Through this research, my didactic coursework, and the guidance of my mentoring team (comprised of a pulmonologist, a biostatistician, an environmental epidemiologist, and an exposure scientist), I will acquire critical skills required to be a successful, independent researcher in environmental health sciences.

项目摘要 我的长期目标是确定个人如何减轻对空气有害健康影响的暴露 通过实际的生活方式调整来污染。我的主要项目目标是调查如何 个人的选择会影响与交通相关的空气污染物（TRAP）和相应的个人暴露 急性健康影响。据报道，交通污染物可能会导致所有与空气污染相关的一半 死亡。尽管这种普遍的负担，非自愿暴露，但很少有研究检查 由于通勤暴露而导致的个人暴露量。通勤者的暴露取决于 运输方式，一天中的时间，路线和燃料类型。公共交通，骑自行车和步行已经 作为减少汽车舰队减少空气污染的方法，很少有研究研究如何 由于运输方式或随后的健康效应的变化，暴露将被修改。 在这项研究中，将要求65名参与者使用两种运输方式（汽车和骑自行车， 轨道或公共汽车）在4天（每模式两天）的典型通勤期间。在每个24小时期间， 将检查参与者的氧化应激生物标志物和急性心血管和 呼吸终点和7+污染物和噪声水平将实时量化。我假设那里 暴露水平和急性健康终点之间将是一个重要的关联。考试将是 进行该关联是否通过运输方式修改。我还将检查 一个人选择上下班在第二个队列中上班和户外运动的时间75 参与者。由于陷阱在两个相对较短的时间内倾向于集中最多（早晨 和晚上的高峰时间），我假设改变曝光时间会显着改变个人 暴露。 该项目将带来个人暴露范式的关键组成部分，个人的决定 - 诱发暴露量减少。我们将确定可修改的因素/个人选择，以减少暴露 为了确定降低暴露的目的可以带来有意义的健康益处。这 知识将使个人能够做出生活方式的选择，以使他们的暴露量独立于独立 环境空气质量或法规变化。这将在研究地点（巴尔​​的摩）中特别有益 在美国，与燃烧相关的死亡率最高的地方，可以预期获得的信息 该K99/R00将适用于具有相似基础设施的其他大都市地区。通过这项研究， 我的教学课程以及我的指导团队的指导（由肺科医生组成，一个 生物统计学家，环境流行病学家和一名曝光科学家），我将获得所需的关键技能 成为一名成功，独立的环境健康科学研究员。

项目成果

Statistical field calibration of a low-cost PM2.5 monitoring network in Baltimore

• DOI: 10.1016/j.atmosenv.2020.117761
• 发表时间: 2020-12-01
• 期刊: ATMOSPHERIC ENVIRONMENT
• 影响因子: 5
• 作者: Datta, Abhirup;Saha, Arkajyoti;Koehler, Kirsten
• 通讯作者: Koehler, Kirsten

Stationary and portable multipollutant monitors for high-spatiotemporal-resolution air quality studies including online calibration.

• DOI: 10.5194/amt-14-995-2021
• 发表时间: 2021-03
• 期刊: ATMOSPHERIC MEASUREMENT TECHNIQUES
• 影响因子: 3.8
• 作者: Buehler, Colby;Xiong, Fulizi;Zamora, Misti Levy;Skog, Kate M.;Kohrman-Glaser, Joseph;Colton, Stefan;McNamara, Michael;Ryan, Kevin;Redlich, Carrie;Bartos, Matthew;Wong, Brandon;Kerkez, Branko;Koehler, Kirsten;Gentner, Drew R.
• 通讯作者: Gentner, Drew R.

One Year Evaluation of Three Low-Cost PM2.5 Monitors.

三款低成本 PM2.5 监测仪的一年评估。

• DOI: 10.1016/j.atmosenv.2020.117615
• 发表时间: 2020
• 期刊: Atmospheric environment (Oxford, England : 1994)
• 作者: Zamora,MistiLevy;Rice,Jessica;Koehler,Kirsten
• 通讯作者: Koehler,Kirsten