Stress Reactivity and Low Back Pain in Older Adults: Influences on Disability (ReLOAD)

老年人的应激反应和腰痛：对残疾的影响 (ReLOAD)

• 批准号: 10701668
• 负责人: Corey Simon
• 金额: $ 23.91万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10701668
• 关键词: Acute; Address; Adrenal Glands; Affect; Aging; Behavior Therapy; Behavioral Model; Biological Markers; Blood; Capsicum; Cardiovascular Diseases; Career Mobility; Chronic; Clinical; Clinical Trials; Clinical Trials Design; Cognitive; Cohort Studies; Coping Behavior; Coping Skills; Data; Dedications; Development; Disease; Elderly; Enrollment; Exposure to; Feeling; Funding; Gait speed; Geriatrics; Goals; Granulocyte-Macrophage Colony-Stimulating Factor; Hydrocortisone; Hypothalamic structure; Individual; Inflammatory; Interleukin-6; International; Intervention; Interview; K-Series Research Career Programs; Knowledge; Laboratories; Leadership; Link; Low Back Pain; Measurement; Measures; Mediating; Mentorship; Monitor; Movement; Neurodegenerative Disorders; Outcome; Pain; Pain Research; Participant; Patient Outcomes Assessments; Patient Self-Report; Peripheral; Physical Function; Physical activity; Physiological; Pilot Projects; Pituitary Gland; Population; Positioning Attribute; Principal Component Analysis; Procedures; Prospective Studies; Questionnaires; Rehabilitation therapy; Reporting; Research; Research Design; Research Personnel; Rotation; Safety; Sampling; Science; Self Efficacy; Serum; Spinal; Stress; Stress Tests; Stressful Event; Structure; Testing; Thinking; Time; Trier Social Stress Test; United States National Institutes of Health; Vertebral column; Walking; Work; biobehavior; biological adaptation to stress; career; career development; coping; cytokine; disability; disability risk; efficacy testing; innovation; mindfulness; mortality; novel; overtreatment; pain catastrophizing; physical therapist; poor health outcome; programs; psychologic; psychological distress; response; stem; stress reactivity; stressor; therapeutic biomarker; therapy development; Acute; Address; Adrenal Glands; Affect; Aging; Behavior Therapy; Behavioral Model; Biological Markers; Blood; Capsicum; Cardiovascular Diseases; Career Mobility; Chronic; Clinical; Clinical Trials; Clinical Trials Design; Cognitive; Cohort Studies; Coping Behavior; Coping Skills; Data; Dedications; Development; Disease; Elderly; Enrollment; Exposure to; Feeling; Funding; Gait speed; Geriatrics; Goals; Granulocyte-Macrophage Colony-Stimulating Factor; Hydrocortisone; Hypothalamic structure; Individual; Inflammatory; Interleukin-6; International; Intervention; Interview; K-Series Research Career Programs; Knowledge; Laboratories; Leadership; Link; Low Back Pain; Measurement; Measures; Mediating; Mentorship; Monitor; Movement; Neurodegenerative Disorders; Outcome; Pain; Pain Research; Participant; Patient Outcomes Assessments; Patient Self-Report; Peripheral; Physical Function; Physical activity; Physiological; Pilot Projects; Pituitary Gland; Population; Positioning Attribute; Principal Component Analysis; Procedures; Prospective Studies; Questionnaires; Rehabilitation therapy; Reporting; Research; Research Design; Research Personnel; Rotation; Safety; Sampling; Science; Self Efficacy; Serum; Spinal; Stress; Stress Tests; Stressful Event; Structure; Testing; Thinking; Time; Trier Social Stress Test; United States National Institutes of Health; Vertebral column; Walking; Work; biobehavior; biological adaptation to stress; career; career development; coping; cytokine; disability; disability risk; efficacy testing; innovation; mindfulness; mortality; novel; overtreatment; pain catastrophizing; physical therapist; poor health outcome; programs; psychologic; psychological distress; response; stem; stress reactivity; stressor; therapeutic biomarker; therapy development

PROJECT SUMMARY/ABSTRACT This application for the Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76) is for Dr. Corey Simon, a physical therapist and geriatric pain researcher specializing in low back pain. Low back pain is one of the world’s most disabling conditions for older adults, with more than 75% reporting persistent disability 1-2 years after onset. A novel disability mechanism among older adults with low back pain is high stress reactivity, which is an acute physiologic response characterized by abnormal changes in blood biomarkers after stressful encounters. High stress reactivity is linked to poorer health outcomes including disability in other chronic conditions; and accumulating research suggests high stress reactivity is mediated by abnormal thoughts and feelings and is modifiable through biobehavioral interventions. However, stress reactivity research in older adults with low back pain is lacking. This proposal in an innovative 5-year research program that builds upon Dr. Simon’s pilot study demonstrating exciting preliminary associations between stress reactivity, physical function, and psychological distress. This proposal will utilize novel laboratory stress reactivity tests, patient-reported outcomes, and qualitative interviews to: 1) Identify and quantify stress reactivity in older adults with low back pain; and 2) For the purpose of reducing disability risks, develop a biobehavioral intervention that targets high stress reactivity in older adults with low back pain. This program will test his central hypothesis that older adults with low back pain and high stress reactivity are at greater risk for disability due to negative thoughts and feelings and poor coping strategies. In addition, this program will provide Dr. Simon with advanced career development in stress reactivity science, behavioral intervention development, and research leadership. Upon completion of this program, Dr. Simon will be poised to facilitate the development of an NIA-funded clinical trial (R34/R01) to test the efficacy of his innovative biobehavioral rehabilitation intervention for older adults with low back pain that targets high stress reactivity. Collectively, this program is the next step in Dr. Simon’s long-term goal to become an international leader in the development of targeted interventions to eradicate disability in older adults with low back pain.

项目摘要/摘要 Paul B. Beeson新兴领导者职业发展奖（K76）的申请是为 物理治疗师和老年疼痛研究人员Corey Simon博士专门研究下背部疼痛。腰背 疼痛是世界上最残疾的老年人之一，有75％以上的报告持续 发病后1 - 2年的残疾。腰痛的老年人中一种新型的残疾机制很高 压力反应性，这是一种以血液异常变化为特征的急性生理反应 压力很大后的生物标志物。高压力反应性与较差的健康结果有关 在其他慢性状况下的残疾；累积研究表明，高压力反应性是由 异常的思想和感受，可以通过生物行为干预进行修改。但是，压力 缺乏腰痛的老年人的反应性研究。该提案在一项创新的5年研究中 基于西蒙博士的试点研究的计划，证明了令人兴奋的初步关联 压力反应性，身体机能和心理困扰。该建议将利用新颖的实验室压力 反应性测试，患者报告的结果和定性访谈：1）识别和量化压力 腰痛的老年人反应性； 2）为了降低残疾风险，发展 靶向高背痛的老年人的生物行为干预措施，其靶向高应激反应性。这个程序将 检验他的中心假设，即腰痛和高压力反应性的老年人面临着更大的风险 由于负面思想和感受以及应对策略不佳而导致的残疾。此外，该程序将 向西蒙博士提供压力反应科学，行为干预的高级职业发展 发展和研究领导。该计划完成后，西蒙博士将被中毒以促进 NIA资助的临床试验（R34/R01）的开发以测试其创新生物行为的效率 针对高背痛的老年人的康复干预，目标是高应激反应性。总的来说，这 计划是西蒙博士长期目标的下一步，成为发展的国际领导者 腰痛的老年人的靶向干预措施。