Widefield Confocal Scanning Laser Ophthalmoscope Optimized for Pediatric and Neonatal Imaging

针对儿科和新生儿成像进行优化的宽视场共焦扫描激光检眼镜

• 批准号: 10701946
• 负责人: Al-Hafeez Zahir Dhalla
• 金额: $ 20.13万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10701946
• 关键词: Address; Adult; Affect; Age; Applications Grants; Blindness; Child; Childhood; Clinical; Clinical Data; Clinical Research; Color; Communication; Computer software; Contact Lenses; Decision Making; Dedications; Development; Device Designs; Devices; Diagnosis; Disease; Engineering; Enrollment; Examination Under Anesthesia; Exposure to; Eye diseases; Fundus photography; Future; Goals; Image; Imaging Device; Imaging technology; Infant; Infant Care; Lasers; Light; Lighting; Near-infrared optical imaging; Neonatal; Ophthalmoscopes; Outcome; Outcome Study; Patients; Pattern; Performance; Premature Infant; Research; Research Project Grants; Resolution; Retina; Retinal Diseases; Retinopathy of Prematurity; Scanning; Scientist; Stress; System; Technology; Time; Training; Translations; United States National Institutes of Health; Validation; Visible Radiation; Vision; commercialization; cost; design; design verification; diagnostic tool; ergonomics; experience; imaging system; improved; meter; neurodevelopment; novel; portability; primary outcome; prototype; real-time images; response; retinal imaging; sample fixation; satisfaction; screening; software development; standard of care; technology development; usability; volunteer

Infants and young children are unable to communicate about loss or disturbance of vision, making it difficult to diagnose vision-threatening diseases before irrevocable vision loss occurs. Commercially available pediatric retinal imaging technologies, including handheld OCT (HH-OCT) and handheld fundus cameras, can be used to screen for and diagnose eye disease in these young patients; however, these technologies have significant drawbacks, such as poor usability, high cost and/or causing significant patient discomfort and stress. One important application of pediatric retinal imaging is the screening of preterm infants for retinopathy of prematurity (ROP). The development of HHOCT has significantly improved our understanding of the progression of ROP, but its use as a diagnostic tool for ROP has been limited by the high cost and poor usability of commercial systems. Similarly, currently available widefield color fundus cameras are prohibitively expensive, and can be stress inducing due to the use of a contact lens and bright illumination flash. Stress associated with the use of these devices can complicate repeat imaging, as young children quickly develop and aversion response to the device. In addition, repeated exposures to stress has been shown to affect neural development in preterm infants. Thus, capturing images in infants and young children with either of these types of systems is expensive, challenging, requiring specialized research staff with significant training. Clearly, there exists a need for a lower- cost and easier to use pediatric retinal imaging system, ideally one that does not cause stress in pre-term infants. This Exploratory/Developmental Research Grant proposal brings together a team of engineers and clinician- scientists with expertise in ophthalmic imaging technology development and translation to develop a pediatric- specific hand-held scanning laser ophthalmoscope (SLO) to address the shortcomings of current commercially available pediatric retinal imaging devices. This technology will substantially improve the standard of care for infants and young children who are currently underserved by existing technologies. To address this unmet clinical need, we propose to construct a prototype, pediatric-specific SLO device and evaluate its clinical feasibility through the following Specific Aims. Specific Aim 1: Develop a Dual-mode, Widefield SLO System with an Ergonomic Handheld Probe. This device will operate in two modes; a non-contact mode providing a 60° FOV and 18 µm resolution at up to 10 frames per second, and a contact mode employing commercially available single-use contact lenses, providing a 120° FOV and 44 µm resolution, also at up to 10 fps. We will also develop real-time image acquisition and display software. Specific Aim 2: Pilot Clinical Study. Use of the proposed SLO system will be compared to current commercial alternatives, comparing the non-contact mode with a non- contact fundus cameras, and the contact mode with a widefield SLO and a contact, widefield fundus camera. The expected outcome of this proposal is the development and initial validation of a pediatric-specific SLO system that will form the basis of future efforts towards clinical validation and ultimate commercialization.

婴儿和幼儿无法就视力的丧失或视力障碍进行交流，使其变得奇异 在不可撤销的竞争中诊断威胁性疾病 视网膜成像技术，不可或缺的手持式OCT（HH-OCT）和手持式底面摄像机可用于 这些年轻患者的筛查和诊断眼睛疾病； 缺点，例如可用性差，会导致严重的患者不适和压力。 小儿视网膜成像的重要应用是对早产的筛查 （ROP）。 但是它用作ROP的诊断工具受到了高成本和商业可用性差的限制 系统。 通过使用隐形眼镜和明亮的照明闪光引起的压力。 这些设备会使复杂的复杂成像复杂化，因为幼儿迅速发展并厌恶对 设备。 婴儿。 具有挑战性，需要进行大量培训的专业研究人员。 成本且易于使用 这项探索性/发展研究赠款二氧化碳汇集了一组工程师和临床医生 - 具有眼科成像技术开发和翻译方面的专业知识的科学家，以发展儿科 特定的手持扫描激光眼镜镜（SLO）以解决货币的缺点 可用的小儿视网膜成像设备。 目前由现有技术提供的婴儿和幼儿。 需要，我们建议构建原型，小儿特异性SLO设备并评估其临床率 通过以下特定目的。 符合人体工程学的手持探针将以两种模式运行。 每秒最多10帧的分辨率和18 µm的分辨率，以及使用Commermercilly可用的接触模式 一次性隐形眼镜，提供120°FOV和44 µm的分辨率，我们还将在10 fps下进行。 实时图像获取和显示软件2。 将SLO系统与当前的商业替代方案进行比较，将非接触模式与非接触模式组成 与宽阔的SLO和触点宽阔的Felcus摄像头联系，并与底面相机联系。 该提案的预期结果是开发的自动验证 将成为临床验证和最终商业化的未来敌方基础的系统。

项目成果

Hybrid spiral scanning in a double-clad fiber-based handheld confocal scanning light ophthalmoscope.

基于双包层光纤的手持式共焦扫描光检眼镜中的混合螺旋扫描。

• DOI: 10.1364/boe.500608
• 发表时间: 2023
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Wei,Franklin;Hagan,Kristen;Viehland,Christian;Tao,YuankaiK;Kuo,AnthonyN;Izatt,JosephA;Dhalla,Al-Hafeez
• 通讯作者: Dhalla,Al-Hafeez