A Multi-Method Study of Extreme Alcohol Drinkers in the Lab and in Real-Life: Increasing Precision of Assessments of Extreme Drinking Determinants

在实验室和现实生活中对极端饮酒者进行的多方法研究：提高极端饮酒决定因素的评估精度

• 批准号: 10677865
• 负责人: DENIS M MCCARTHY
• 金额: $ 44.05万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-25 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10677865
• 关键词: Adult; Age; Alcohol consumption; Alcohols; Attention; Behavior; Behavior assessment; Blood alcohol level measurement; Cellular Phone; Chronic; Consumption; Cross-Sectional Studies; Cues; Data; Databases; Diagnosis; Dimensions; Dose; Ecological momentary assessment; Economic Burden; Electrophysiology (science); Elements; Environment; Epidemiology; Ethics; Event; Frequencies; Genetic; Genotype; Health; Heavy Drinking; Hour; Impulsivity; Individual; Individual Differences; Intervention; Investigation; Knowledge; Laboratories; Laboratory Study; Legal; Life; Limb structure; Longitudinal Studies; Measures; Memory impairment; Methods; Minority; Modality; Modeling; Moods; Participant; Patient Self-Report; Personality; Phenotype; Process; Public Health; Questionnaires; Recurrence; Research; Rewards; Risk; Sampling; Severities; Societies; Source; Surveys; Testing; Theoretical model; Time; Woman; absorption; addiction; adverse outcome; alcohol behavior; alcohol exposure; alcohol measurement; alcohol outlet density; alcohol poisoning; alcohol related consequences; binge drinker; binge drinking; contextual factors; craving; density; design; drinking; drinking behavior; high intensity drinking; high risk; high risk drinking; incentive salience; indexing; men; mobile computing; negative affect; new technology; polygenic risk score; portability; prospective; recruit; substance use; therapeutic target; trait; young adult

High levels of alcohol consumption clearly place individuals at great risk and present a significant health and economic burden to society. Emerging evidence indicates that many young adults engage in what can be called extreme drinking (i.e., drinking at levels likely to lead to BACs > .16). Despite recent attention to extreme drinking5,6, we know surprisingly little about this behavior beyond associations revealed by cross‐sectional studies that rely exclusively on retrospective self‐report. The proposed study is designed to provide some of the first comprehensive data about influences on the extreme drinking phenotype, and to compare these with those identified for the typical binge drinking phenotype. Whether there are unique causes and correlates of extreme drinking (compared to binge drinking) is an empirical question that has not been tested. There are challenges to investigating extreme drinking, including 1) overcoming the limitations of retrospective self‐report, 2) adequately measuring personological and environmental influences, and 3) capturing the temporal associations of these diverse influences and their impact on extreme drinking occasions. The proposed project is designed to meet these challenges using a combination of laboratory, genetic, and ecological momentary assessment (EMA) methods. Our multi‐method approach will combine laboratory alcohol administration, EMA, and real‐time BAC assessment to capture the interplay between a broad range of potential influences on extreme drinking, extend our investigation outside the lab and into the natural drinking environment, and explore the temporal associations of influences on extreme drinking. We focus on four core constructs central to current theoretical models of addiction that are hypothesized to influence substance use through in‐the‐moment processes: reward sensitivity (RS), incentive salience (IS), impulsivity/loss of control (Imp), and negative affectivity (NA). We will recruit a sample of 400 young adults (ages 21‐29), ascertained from a statewide DMV database, who have a recent legal action with a recorded BAC consistent with extreme drinking (≥ .12). Using a longitudinal burst design, we will follow participants over a 12‐month period, with five self‐report assessments and four, two‐week EMA bursts. A baseline laboratory session will assess behavioral, trait, and electrophysiological markers of core study constructs. We aim to (1) Evaluate the validity and utility of real‐time assessments for identifying extreme drinking and alcohol‐related behavior. This aim could inform estimation methods for characterizing extreme drinking and guide refinement of definitions of problematic drinking profiles. (2) Characterize the structural influence of stable individual differences, transient intra‐individual factors, and environmental variables on risky, binge, and extreme drinking occasions and alcohol‐related negative consequences. This aim will reveal the incremental validity of state (EMA) and trait (lab; baseline questionnaires; polygenic risk scores [PRSs] when applicable) indices of core study constructs in predicting extreme drinking occasions within and between individuals; as well as test their interaction with specific contextual factors to predict extreme drinking behavior. (3) Identify multidimensional profiles associated with stable or highly variable binge and extreme drinking behavior. Our longitudinal burst design allows us to test hypotheses about the stability of drinking behavior over time.

高水平的酒精咨询显然使个人面临很大的风险，并呈现出重大的健康和经济 对社会的负担。 （即，饮酒的水平喜欢导致BAC> .16）。 几乎没有依赖依赖的跨性依赖研究依赖依赖的依赖的行为的行为，依赖于urrostivee 自我报告。 极端的饮酒表型，并将其与典型的饮酒表型标识的表型进行比较。 是否有原因和极端饮酒的相关性（与暴饮暴食相比）是一个经验问题 调查极端饮酒有挑战，包括1）克服限制 回顾性自我报告，2）充分衡量人力学和环境影响，3）捕获3） 各种影响的时间关联以及对拟议项目的极端饮酒的影响 旨在使用实验室，遗传和生态瞬时评估的组合来应对挑战 （EMA）方法。 评估以捕获对极端饮酒的广泛潜在影响之间的解释，扩展我们 在实验室外调查自然饮酒环境，并探索 对极端饮酒的影响。 假设会影响物质的使用 - 强大过程：奖励灵敏度（RS） （IS），冲动/丧失对照（IMP）和负面影响（NA）。 21-29），从全州DMV数据库中确定，他们最近采取了记录的法律诉讼 极端饮酒（≥.12）。 自我报告评估和四个周的EMA爆发。 核心研究结构的电生理标记。我们的目标是（1） 评估极端饮酒和与酒精相关的行为。 为了表征有问题的饮酒概况定义的极端饮酒和指导 稳定个体差异，瞬态内部因素和环境变量的结构影响 在风险，暴饮暴食和极端饮酒场合以及与酒精有关的负面结构上。 状态（EMA）和性状的增量有效性（实验室；基线问卷；适用时多基因风险得分[PRSS]） 核心研究结构的指标，以预测个人之间和之间的极端饮酒场合； 他们与特定上下文因素的相互作用以预测极端饮酒行为。 与稳定或高度可变的狂欢和极端饮酒行为相关的轮廓。 允许我们测试有关饮酒行为​​稳定性的假设。