Administrative Core-Biomarkers for optimizing risk prediction and early detection of cancers of the colon and esophagus

用于优化结肠癌和食道癌风险预测和早期检测的管理核心生物标志物

• 批准号: 10677826
• 负责人: William Mallory Grady
• 金额: $ 41.74万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-05 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10677826
• 关键词: Administrative Coordination; Administrator; Biological Assay; Biological Markers; CLIA certified; Cancer Intervention and Surveillance Modeling Network; Clinical; Collaborations; Communication; Data; Data Analyses; Data Commons; Data Coordinating Center; Development; Early Detection Research Network; Early Diagnosis; Education; Environment; Funding; Funding Agency; Future; Industrialization; Institution; Letters; Malignant neoplasm of esophagus; Malignant neoplasm of gastrointestinal tract; Mission; Process; Productivity; Rana; Research; Research Personnel; Running; Scientist; Screening for cancer; Structure; System; Teleconferences; United States National Institutes of Health; Validation; Work; biomarker discovery; biomarker validation; clinical biomarkers; clinical development; colon cancer screening; data dissemination; data sharing; data submission; industry partner; innovation; interest; meetings; member; operation; organizational structure; programs; protocol development; risk prediction; success; validation studies; Administrative Coordination; Administrator; Biological Assay; Biological Markers; CLIA certified; Cancer Intervention and Surveillance Modeling Network; Clinical; Collaborations; Communication; Data; Data Analyses; Data Commons; Data Coordinating Center; Development; Early Detection Research Network; Early Diagnosis; Education; Environment; Funding; Funding Agency; Future; Industrialization; Institution; Letters; Malignant neoplasm of esophagus; Malignant neoplasm of gastrointestinal tract; Mission; Process; Productivity; Rana; Research; Research Personnel; Running; Scientist; Screening for cancer; Structure; System; Teleconferences; United States National Institutes of Health; Validation; Work; biomarker discovery; biomarker validation; clinical biomarkers; clinical development; colon cancer screening; data dissemination; data sharing; data submission; industry partner; innovation; interest; meetings; member; operation; organizational structure; programs; protocol development; risk prediction; success; validation studies

PROJECT SUMMARY The Administrative Core (AC) of our Biomarker Characterization Center (BCC) will facilitate and optimize the integration of biomarker discovery and initial validation studies by the Biomarker Discovery Lab (BDL) and the development and validation studies to create clinical-grade, CLIA compliant biomarker assays by the Biomarker Reference Lab (BRL). The Administrative Core will be managed by the Center Administrator and run by the PIs of the BDL and BRL. It will support and enhance cross BCC and cross EDRN communication, data dissemination and data review and analysis, which will promote the BCC’s core mission to discovery and validate clinical grade biomarker assays for GI cancer risk prediction and early detection The Administrative Core will provide administrative support for collaborations and communications between the EDRN BCCs, Clinical Validation Centers (CVCs), Data Management Center (DMCC); collaborating industrial partners (e.g. Cernostics, Qiagen, etc.) and academic partners, and collaborating NCI programs (e.g. CISNET, NIST, etc.). Through the functions of the Administrative Core, the BCC with other EDRN BCCs, CVC, and DMCC, industrial partners, and academic partners will collaborate not only on the BCC’s studies but also on resulting derivative studies and other EDRN BCC and CVC projects that arise from the BCC’s highly innovative, productive and significant program of biomarker discovery and validation for GI cancer risk prediction and early detection and the programs of other BCCs. The Administrative Core has the following aims: Aim 1: To provide the organizational structure for supporting the key objectives of the BCC, which are the BDL’s and BRL’s scientific and educational missions and the successful collaboration among the BDL and BRL PI and scientists, EDRN partners, academic partners and industrial partners. Aim 2: To provide efficiency in management of large-scale collaborative research efforts involving multiple institutions and multiple PDs/PIs, including local and national meetings management. Aim 3: To coordinate with EDRN DMCC for protocol development, biospecimen sharing, biospecimen blinding, data analysis, data sharing, data deposition, populating Biomarker Data Commons, and any other relevant functions deemed necessary for BCC operations as well as for the larger Network.

项目摘要 我们生物标志物特征中心（BCC）的行政核心（AC）将有助于和优化 生物标志物发现和生物标志物发现实验室（BDL）和初始验证研究的整合 开发和验证研究以创建临床级，CLIA符合CLIA的生物标志物测定法 生物标志物参考实验室（BRL）。管理核心将由中心管理员管理并运行 由BDL和BRL的PI。它将支持并增强Cross BCC和Cross Edrn通信，数据 传播和数据审查和分析，这将促进BCC的核心使命发现和验证 胃肠道癌风险预测和早期检测的临床级生物标志物测定行政核心将 为EDRN BCC之间的合作和沟通提供行政支持，临床 验证中心（CVC），数据管理中心（DMCC）；协作工业合作伙伴（例如，Cernostics， Qiagen等）和学术合作伙伴，以及合作NCI计划（例如Cisnet，Nist等）。通过 行政核心的功能，与其他EDRN BCC，CVC和DMCC，工业合作伙伴和DMCC的功能 学术合作伙伴不仅将在BCC的研究中进行合作，还将在产生的衍生研究和 其他EDRN BCC和CVC项目是由BCC高度创新，富有成效和重要的 生物标志物发现和胃肠癌风险预测和早期检测的验证计划以及这些程序 其他BCC。 行政核心具有以下目的： 目标1：提供支持BCC的关键目标的组织结构，这是BDL的 以及BRL的科学和教育任务以及BDL和BRL PI和 科学家，EDRN合作伙伴，学术合作伙伴和工业伙伴。 目标2：为管理涉及多个的大规模协作研究工作提供效率 机构和多个PDS/PI，包括本地和国家会议管理。 AIM 3：与EDRN DMCC协调协议开发，生物测量共享，生物镜盲， 数据分析，数据共享，数据沉积，填充生物标志物数据共享以及任何其他相关的 BCC操作以及较大网络所必需的功能。