Multi-site Data for Nutrition Studies in Healthy Early Childhood

健康幼儿营养研究的多站点数据

• 批准号: 10676921
• 负责人: Yangming Ou
• 金额: $ 8.85万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-04 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10676921
• 关键词: Adolescence; Adult; Affect; Algorithms; Archives; Area; Behavior; Birth; Boston; Brain; Brain imaging; Breast Feeding; Carotenoids; Child; Child Health; Childhood; China; Chinese; Clinical Trials; Combinatorics; Data; Data Set; Dementia; Demographic Factors; Development; Diet; Dietary intake; Diffusion; Elderly; Environment; Feeding Patterns; Food; Food Interactions; Frequencies; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Health; Hour; Human Development; Human Milk; Infant; Italy; Lactation; Letters; Life; Life Style; Link; Magnetic Resonance Imaging; Manuals; Metadata; Milk; Mothers; Motor; National Institute of Child Health and Human Development; Netherlands; Neurocognition; Neurocognitive; Newborn Infant; Norway; Nutrient; Outcome; Parents; Participant; Patient Self-Report; Pediatric Hospitals; Pigments; Pollution; Population; Poverty; Premature Infant; Process; Questionnaires; Recommendation; Research Personnel; Rest; Sampling; School-Age Population; Site; Socioeconomic Status; Spain; Strategic Planning; Stress; Structure; Testing; United States National Institutes of Health; Visit; Woman; autism spectrum disorder; brain health; brain magnetic resonance imaging; cohort; combat; data dictionary; data structure; demographics; density; diaries; dietary; early childhood; follow-up; high risk infant; improved; infancy; macula; maternal obesity; morphometry; mother nutrition; neonatal brain; nutrition; offspring; precision nutrition; prospective; recruit; secondary analysis; symposium; tool; user-friendly; Adolescence; Adult; Affect; Algorithms; Archives; Area; Behavior; Birth; Boston; Brain; Brain imaging; Breast Feeding; Carotenoids; Child; Child Health; Childhood; China; Chinese; Clinical Trials; Combinatorics; Data; Data Set; Dementia; Demographic Factors; Development; Diet; Dietary intake; Diffusion; Elderly; Environment; Feeding Patterns; Food; Food Interactions; Frequencies; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Health; Hour; Human Development; Human Milk; Infant; Italy; Lactation; Letters; Life; Life Style; Link; Magnetic Resonance Imaging; Manuals; Metadata; Milk; Mothers; Motor; National Institute of Child Health and Human Development; Netherlands; Neurocognition; Neurocognitive; Newborn Infant; Norway; Nutrient; Outcome; Parents; Participant; Patient Self-Report; Pediatric Hospitals; Pigments; Pollution; Population; Poverty; Premature Infant; Process; Questionnaires; Recommendation; Research Personnel; Rest; Sampling; School-Age Population; Site; Socioeconomic Status; Spain; Strategic Planning; Stress; Structure; Testing; United States National Institutes of Health; Visit; Woman; autism spectrum disorder; brain health; brain magnetic resonance imaging; cohort; combat; data dictionary; data structure; demographics; density; diaries; dietary; early childhood; follow-up; high risk infant; improved; infancy; macula; maternal obesity; morphometry; mother nutrition; neonatal brain; nutrition; offspring; precision nutrition; prospective; recruit; secondary analysis; symposium; tool; user-friendly

Project Summary/Abstract This project aims to release our recently gathered unique data for nutrition studies of healthy term-born infants through school age. Brain development is a major health domain, and infancy is a period when the brain develops most rapidly and is perhaps most vulnerable to the lack of nutrition. Studies on nutrition’s effect on brain health are mostly on the elderly especially dementia populations. Very few studies on nutrition’s effect on brain healthy are on infants, but mostly on infants born pre-term, who clearly need nutrition supplements but only account for ~10% of all newborns. Term-born healthy infants constitute ~90% of newborns, and they pose specific requirement for nutrition, but are rarely studied. In 2014-2018 (clinical trial NCT02058225), we have acquired comprehensive data to study how maternal dietary intake of nutrition impacts healthy term-born infants’ brain health during the first 3 months after birth. In 2019-2020, we have additionally collected neurocognitive outcome questionnaires now that those children are in early school age. Overall, our data were collected in two large women’s and children’s hospitals for 145 healthy mother-infant dyads. Our data include: (1) demographics of parents and infants; (2) food frequency questionnaires (FFQ) of maternal dietary intake of nutrition during lactation, which were already converted into 73 nutrients; (3) milk feeding patterns (breastmilk- or formula, or a combination); (4) socioeconomic status and lifestyle questionnaires from the parents; (5) breastmilk nutrition components; (6) maternal macular pigment ocular density (MPOD), which is an easy-to-obtain, quantitative reflection of specific maternal nutrition in carotenoids; (7) infant brain MRI (structural, diffusion, functional) at 1 and 3-month of life after birth; (8) infant Mullen score reflecting neurocognitive functions at 3 months (e.g., motor); and (9) neurocognitive questionnaires and the converted neurocognitive scores at early school age (4-6 years). We propose to organize the data (Aim 1), process and harmonize multi-site MRI (Aim 2), and publicly-release this otherwise rarely-available comprehensive data (Aim 3). This data can help study how dietary and breastmilk nutrition are related to early-infancy brain structure and function, how they correlate with school-age neurocognition, and how they interact with socioeconomic status and demographic factors.

项目摘要/摘要 该项目旨在释放我们最近收集的独特数据，用于健康的术语出生婴儿 到学龄。大脑发育是一个主要的健康领域，婴儿期是大脑发展的时期 最迅速的，可能最容易受到缺乏营养的影响。关于营养对大脑健康影响的研究 它们主要是在上古老的痴呆症种群上。很少有关于营养对大脑健康影响的研究 在婴儿身上，但主要是出生于早期的婴儿，他们显然需要营养补充剂，但仅考虑 所有新生儿的10％。长期出生的健康婴儿占新生儿的90％，它们构成了特定的 营养的要求，但很少研究。在2014-2018（临床试验NCT02058225），我们已获得 综合数据，以研究孕产妇饮食摄入营养如何影响健康的年龄出生婴儿的大脑 出生后的头三个月中的健康状况。在2019 - 2020年，我们还收集了神经认知结果 问卷现在是这些孩子在早期的年龄。总体而言，我们的数据是在两个大的 妇女和儿童医院可容纳145个健康的母亲二元组。我们的数据包括：（1） 父母和婴儿； （2）孕产妇饮食摄入营养摄入量的食物频率问卷（FFQ） 泌乳，已经转化为73种营养； （3）牛奶进食模式（母乳或配方，或 组合）; （4）父母的社会经济地位和生活方式问卷； （5）母乳营养 成分; （6）母体黄斑色素的眼密度（MPOD），它是一种易于使用的定量 类胡萝卜素中特定材料营养的反射； （7）婴儿脑MRI（结构，扩散，功能）在1 出生后三个月的生活； （8）婴儿穆伦评分反映了3个月时神经认知功能的评分（例如运动）； （9）神经认知问卷和早期转化的神经认知评分（4-6岁）。 我们建议组织数据（AIM 1），处理和协调多站点MRI（AIM 2），并公开发行 这个原本很少有可用的综合数据（AIM 3）。这些数据可以帮助研究饮食和母乳 营养与早期体内的大脑结构和功能有关，它们如何与学龄 神经认知以及它们如何与社会经济地位和人口统计学因素相互作用。