Using CBT to Probe Psychobiobehavioral Resilience to Post-trauma Psychopathology

使用 CBT 探讨创伤后精神病理学的心理生物行为弹性

• 批准号: 8820735
• 负责人: Alyson Kay Zalta
• 金额: $ 15.38万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-25 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8820735
• 关键词: Academic Medical Centers; Adolescence; Adverse event; Allopregnanolone; Animal Model; Anxiety; Area; Behavioral; Behavioral Sciences; Biological; Biological Markers; Biological Sciences; Buffers; Chicago; Child Abuse; Childhood; Clinical; Clinical Trials; Cognitive; Commit; Complex; Conduct Clinical Trials; Control Groups; Data; Development; Distress; Environment; Event; Evidence based treatment; Exhibits; Extinction (Psychology); Failure; Future; Goals; Health education; Individual; Intervention; Intervention Studies; Knowledge; Lead; Link; Mental Health; Mental disorders; Mentors; Mentorship; Methods; Modification; National Institute of Mental Health; Neurobiology; Participant; Post-Traumatic Stress Disorders; Prevention program; Prevention strategy; Preventive Intervention; Process; Psychological Factors; Psychopathology; Qualifying; Randomized; Recording of previous events; Reporting; Research; Research Personnel; Research Training; Risk; Risk Factors; Scientist; Side; Social support; Stress; Symptoms; Testing; Time; Training; Translational Research; Trauma; Violence; Woman; Work; acute stress; analog; base; career; career development; conditioned fear; coping; dehydroepiandrosterone; depressive symptoms; design; emotion regulation; experience; follow-up; high risk; improved; learning extinction; men; neuropeptide Y; optimism; patient oriented; post intervention; prevent; programs; psychologic; public health relevance; resilience; response; skills; stress management; stressor; theories

 DESCRIPTION (provided by applicant): The PI's long-term career goal is to become an independent clinical scientist conducting translational research aimed at establishing risk and resilience processes associated with mental illness following trauma and developing preventive interventions that target these mechanisms. Risk and resilience to traumatic stress involves a complex interplay of psychological, biological, and behavioral processes; thus, the candidate aims to integrate neurobiology and behavioral science in the pursuit of this research program. This proposal outlines a training and research plan to achieve this goal, culminating in a successful R01 proposal. This plan takes full advantage of the candidate's strong institutional support and environment at Rush University Medical Center as well as a team of mentors, collaborators, and consultants with expertise in each of the critical training areas. The candidate's early focus has been in vulnerability mechanisms associated with anxiety. She also has experience with clinical trials research, biological markers of acute stress, and delivering evidence-based treatments for PTSD. The candidate seeks to build upon this skill set by pursuing training goals aimed at developing 1) expertise in risk and resilience to traumatic stress, 2) proficiency in conducting clinical trials, 3) a sophisticated understanding of the neurobiology of conditioned fear and responses to traumatic stress, and 4) mastery in conducing translational research that integrates biological and behavioral science. By synthesizing these training goals, the candidate will develop a unique patient-oriented career aimed at reducing the burden of trauma-related psychopathology through the development of translational preventive interventions. The research plan uses Stress Inoculation Training (SIT), a well-established cognitive behavioral stress management intervention, to probe risk and resilience mechanisms linked to post-trauma psychopathology. Ninety participants with a history of interpersonal trauma during childhood or adolescence and mild to moderate distress will be randomized to SIT or a health education control condition. The primary aims of this proposal are to examine whether individuals who receive SIT demonstrate increases in psychological resilience, biological resilience, and extinction learning compared to those in the control group. This proposal will also explore associations between these psychobiobehavioral risk and resilience factors. The specific aims of the proposal match well with the strategic goals of NIMH in that this study aims to explore dimensional processes of risk and resilience that cut across psychological disorders. By establishing the malleability of these risk and resilience candidates, the results of this study could have clinical utility in refining prevention strategies and will prepare the candidate to submit an R01 proposal examining the extent to which modification of underlying psychobiobehavioral risk and resilience mechanisms prevents psychopathology following future trauma exposure.

 描述（由申请人提供）：PI 的长期职业目标是成为一名独立的临床科学家，进行转化研究，旨在建立与创伤后精神疾病相关的风险和恢复过程，并制定针对这些机制的预防干预措施。创伤性应激涉及心理、生物和行为过程的复杂相互作用；因此，候选人旨在将神经生物学和行为科学整合到该研究计划中，以实现这一目标，最终形成一个培训和研究计划。该计划充分利用了候选人在拉什大学医学中心的强大机构支持和环境，以及在每个关键培训领域具有专业知识的导师、合作者和顾问团队。她还拥有与焦虑相关的脆弱性机制方面的经验，以及临床试验研究、急性应激的生物标志物以及针对创伤后应激障碍（PTSD）提供循证治疗的经验。候选人力求通过追求旨在发展 1) 专业知识的培训目标来增强这一技能。创伤风险和恢复力压力，2）熟练进行临床试验，3）对条件性恐惧和创伤压力反应的神经生物学的深入理解，以及4）掌握进行整合生物学和行为科学的转化研究通过综合这些培训目标，候选人。将开发一种独特的以患者为导向的职业，旨在通过开发转化性预防干预措施来减轻创伤相关的精神病理学负担。该研究计划使用压力接种训练（SIT），这是一种行之有效的认知疗法。行为压力管理干预，以探讨与创伤后精神病理学相关的风险和恢复机制。 90 名有童年或青春期创伤史和轻度至中度痛苦的参与者将被随机分配到 SIT 或健康教育控制条件。该提案旨在检查接受 SIT 的个体与对照组相比是否表现出心理弹性、生物弹性和消退学习能力的提高。该提案还将探讨这些心理生物行为风险和弹性因素之间的关联。与NIMH 的战略目标是，本研究旨在探索跨越心理障碍的风险和复原力的维度过程。通过确定这些风险和复原力候选者的可塑性，本研究的结果可以在完善预防策略方面具有临床实用性，并将为制定预防策略做好准备。候选人提交一份 R01 提案，审查潜在心理生物行为风险和复原力机制的改变在多大程度上预防未来创伤暴露后的精神病理学。