Hormone receptor associated epigenetic reprogramming as a mediator of environmental exposure in women's health

激素受体相关的表观遗传重编程作为女性健康环境暴露的中介

• 批准号: 10699690
• 负责人: Elizabeth Martin
• 金额: $ 64.51万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10699690
• 关键词: Breast Cancer Risk Factor; Cell Proliferation; Cells; Disease; Endocrine Disruptors; Endocrine disruption; Environmental Exposure; Environmental Risk Factor; Epigenetic Process; Exposure to; Goals; Hormonal Change; Hormone Receptor; Lead; Ligands; Mediator of activation protein; Phenotype; Predisposition; Pregnancy; Progesterone; Progesterone Receptors; Research; T47D; Women' s Health; activating transcription factor; maternal risk; phthalates; programs; receptor; Breast Cancer Risk Factor; Cell Proliferation; Cells; Disease; Endocrine Disruptors; Endocrine disruption; Environmental Exposure; Environmental Risk Factor; Epigenetic Process; Exposure to; Goals; Hormonal Change; Hormone Receptor; Lead; Ligands; Mediator of activation protein; Phenotype; Predisposition; Pregnancy; Progesterone; Progesterone Receptors; Research; T47D; Women' s Health; activating transcription factor; maternal risk; phthalates; programs; receptor

In this past year we have demonstrated that phthalates can impact the phenotype, specifically cell proliferation, of T47D cells in culture. Further, this phenotype is altered in the presence of endogenous progesterone suggesting endocrine disruption via progesterone receptor as a potential mechanism by which phthalate exposure may later breast cancer risk. These findings also suggest that exposure to endocrine disrupting compounds such as phthalates maybe more important during key windows of susceptibility, such as pregnancy.

在过去的一年中，我们证明了邻苯二甲酸酯可以影响培养物中T47D细胞的表型，特别是细胞增殖。此外，在存在内源性孕激素的存在下，这种表型通过孕激素受体的内分泌破坏而改变，这是邻苯二甲酸酯暴露可能后来乳腺癌风险的潜在机制。这些发现还表明，在关键易感性（例如怀孕）的关键窗口中，邻苯二甲酸盐（例如邻苯二甲酸盐）的内分泌破坏化合物的暴露可能更为重要。