THE GENETICS AND MULTI-OMICS SPECIMENS CORE (GMSC)
遗传学和多组学样本核心 (GMSC)
基本信息
- 批准号:10673899
- 负责人:
- 金额:$ 71.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-30 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
ABSTRACT FOR GMSC
Aging populations worldwide, particularly in developed countries, face an increasing burden of
neurodegenerative diseases. Genetic studies have greatly contributed to our understanding of these complex
diseases. Now it is clear that studies beyond genetics, such as transcriptomics, proteomics, or epigenomics are
needed to fully understand the biology of neurodegeneration and healthy aging, to identify novel biomarkers and
identify novel targets. The goal of the Genomics and Multi-omics Specimens core (GMSC) is to obtain, bank and
quality control (QC) biospecimens (DNA, RNA and plasma) from AABC participants. The core will generate
GWAS, APOE and polygenic risk scores for all participants that will be used by other AABC Projects. We will
also generate longitudinal multi-omic (classic blood analytes, anti-Müllerian hormone (AMH), Alzheimer disease
(AD) biomarkers, and neuroinflammation proteomics) blood data that will be used for Projects 1-4 to determine
biomarker positivity for AD, allosteric load, inflammation, lifestyle behaviors, and the menopausal transition that
are instrumental for those projects.
GMSC的摘要
全世界的人口老龄化,特别是在发达国家中,面临着越来越多的
神经退行性疾病。遗传研究极大地有助于我们对这些复杂的理解
疾病。现在很明显,遗传学以外的研究,例如转录组学,蛋白质组学或表观基因组学是
需要充分了解神经退行性和健康衰老的生物学,以识别新颖的生物标志物和
确定新颖的目标。基因组学和多词标本核心(GMSC)的目的是获得银行和
来自AABC参与者的质量控制(QC)生物测量(DNA,RNA和等离子体)。核心将生成
其他AABC项目将使用的所有参与者的GWA,APOE和多基因风险得分。我们将
还会产生纵向多词(经典血液分析物,抗肿瘤激素(AMH),阿尔茨海默氏病
(AD)生物标志物和神经炎症蛋白质组学)血液数据将用于1-4的项目
广告的生物标志物积极性,变构负载,创新,生活方式行为以及更年期过渡
对这些项目有用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

暂无数据
数据更新时间:2024-06-01
Carlos Cruchaga的其他基金
Identification and Characterization of Cell-Specific Transposable Elements Implicated on Alzheimer Disease and Healthy Aging
与阿尔茨海默病和健康衰老相关的细胞特异性转座元件的鉴定和表征
- 批准号:1051893410518934
- 财政年份:2022
- 资助金额:$ 71.63万$ 71.63万
- 项目类别:
Multimodal Characterization of the Role of Circular RNAs in Alzheimer's Disease
环状 RNA 在阿尔茨海默病中作用的多模式表征
- 批准号:1044636210446362
- 财政年份:2022
- 资助金额:$ 71.63万$ 71.63万
- 项目类别:
Identification and Characterization of Cell-Specific Transposable Elements Implicated on Alzheimer Disease and Healthy Aging
与阿尔茨海默病和健康衰老相关的细胞特异性转座元件的鉴定和表征
- 批准号:1067789410677894
- 财政年份:2022
- 资助金额:$ 71.63万$ 71.63万
- 项目类别:
Genetic Architecture of Alzheimer’s disease Proteinopathies
阿尔茨海默病的遗传结构 蛋白质病
- 批准号:99956509995650
- 财政年份:2021
- 资助金额:$ 71.63万$ 71.63万
- 项目类别:
Genetic Architecture of Alzheimer’s disease Proteinopathies
阿尔茨海默病的遗传结构 蛋白质病
- 批准号:1039142610391426
- 财政年份:2021
- 资助金额:$ 71.63万$ 71.63万
- 项目类别:
THE GENETICS AND MULTI-OMICS SPECIMENS CORE (GMSC)
遗传学和多组学样本核心 (GMSC)
- 批准号:1028306710283067
- 财政年份:2021
- 资助金额:$ 71.63万$ 71.63万
- 项目类别:
Genetic Architecture of Alzheimer’s disease Proteinopathies
阿尔茨海默病的遗传结构 蛋白质病
- 批准号:1058159910581599
- 财政年份:2021
- 资助金额:$ 71.63万$ 71.63万
- 项目类别:
Brain Single-nuclei and iPS-derived cells transcriptomic analysis to define the contribution of neuronal and glial pathw
脑单核和 iPS 衍生细胞转录组分析以确定神经元和神经胶质通路的贡献
- 批准号:1030216210302162
- 财政年份:2021
- 资助金额:$ 71.63万$ 71.63万
- 项目类别:
Genetic Architecture of Alzheimer’s disease Proteinopathies
阿尔茨海默病的遗传结构 蛋白质病
- 批准号:1053258110532581
- 财政年份:2021
- 资助金额:$ 71.63万$ 71.63万
- 项目类别:
相似海外基金
Vision Impairment in the National Health and Aging Trends Study: Epidemiology, Social Determinants of Health, and Adverse Late Life Outcomes
国家健康和老龄化趋势研究中的视力障碍:流行病学、健康的社会决定因素和不良的晚年结局
- 批准号:1073041810730418
- 财政年份:2023
- 资助金额:$ 71.63万$ 71.63万
- 项目类别:
Driving the Progeny of Olfactory HBC Stem Cells toward Neuronal Differentiation
驱动嗅觉 HBC 干细胞后代向神经元分化
- 批准号:1052716710527167
- 财政年份:2022
- 资助金额:$ 71.63万$ 71.63万
- 项目类别:
Driving the Progeny of Olfactory HBC Stem Cells toward Neuronal Differentiation
驱动嗅觉 HBC 干细胞后代向神经元分化
- 批准号:1064289010642890
- 财政年份:2022
- 资助金额:$ 71.63万$ 71.63万
- 项目类别:
THE INFORMATICS, DATA ANALYSIS, AND STATISTICS CORE (IDASC)
信息学、数据分析和统计核心 (IDASC)
- 批准号:1028306610283066
- 财政年份:2021
- 资助金额:$ 71.63万$ 71.63万
- 项目类别:
Prognostic Implications of Home-Based Blood Pressure Monitoring in Older Adults
老年人家庭血压监测的预后意义
- 批准号:1063118510631185
- 财政年份:2021
- 资助金额:$ 71.63万$ 71.63万
- 项目类别: