Trans-ethnic meta-analysis of blood pressure in African and European ancestries

非洲和欧洲血统血压的跨种族荟萃分析

基本信息

批准号：
8755381
负责人：
Nora Franceschini
金额：
$ 12.83万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-01 至 2016-05-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8755381
关键词：
Affect African African American Aging American Indians Asians Biological Markers Blood Pressure Cardiovascular Diseases Chronic Kidney Failure Clinical Collaborations Computer software Coronary heart disease Data Development Drug Targeting Epidemiology European Gene Frequency Genetic Genetic Determinism Genetic Variation Genomics Genotype Goals Health Heart Heritability Heterogeneity Hispanics Hypertension Individual Japanese Population Kidney Kidney Diseases Knowledge Lead Linkage Disequilibrium Maps Meta-Analysis Methods National Heart, Lung, and Blood Institute Outcome Pathway interactions Pattern Population Population Heterogeneity Prevention strategy Reporting Research Resources Risk Sample Size Sampling Statistical Methods Stroke Subgroup Variant Work base blood pressure regulation burden of illness cardiovascular disorder risk cohort cost effective disability ethnic difference gene discovery genetic epidemiology genetic variant genome wide association study hypertension treatment improved innovation insight mortality novel pleiotropism public health relevance racial and ethnic racial and ethnic disparities racial/ethnic difference trait

项目摘要

DESCRIPTION (provided by applicant): Hypertension is a leading cause of global disease burden, mortality and disability, contributing to a greater risk of cardiovascular disease, stroke and chronic kidney disease. African Americans are disproportionally affected by hypertension and its complications. Whether these racial/ethnic differences in hypertension risk are related to genetic factors is currently unknown. Studies of individuals of diverse ancestry have provided evidence for presence of additional common variants in the population with broad effects across ancestries, which could be leveraged for gene discovery in trans-ethnic meta-analysis. Using genome wide association study data from the COGENT-BP and CHARGE-BP consortia, we propose to perform trans-ethnic meta-analyses of blood pressure traits in individuals of African and European ancestry for variant discovery and fine mapping of loci, by leveraging trans-ethnic differences in allele frequencies and the patterns of linkage disequilibrium. We will examine the evidence for association of the most significantly associated blood pressure variants with clinical relevant cardiovascular disease and kidney outcomes in collaborations with established consortia. Findings from this study could have a broad impact on gene discovery and fine mapping of loci, and may provide information on genetic determinants of racial/ethnic disparities to guide strategies for prevention and treatment of hypertension and its complications.

描述（由申请人提供）：高血压是全球疾病负担、死亡和残疾的主要原因，导致心血管疾病、中风和慢性肾病的风险增加。非裔美国人受高血压及其并发症的影响尤为严重。目前尚不清楚高血压风险的这些种族/民族差异是否与遗传因素有关。对不同血统个体的研究提供了证据，证明人群中存在其他常见变异，这些变异对不同血统具有广泛影响，可用于跨种族荟萃分析中的基因发现。利用来自 COGENT-BP 和 CHARGE-BP 联盟的全基因组关联研究数据，我们建议对非洲和欧洲血统个体的血压特征进行跨种族荟萃分析，以利用跨种族基因座的变异发现和精细定位。 -等位基因频率和连锁不平衡模式的种族差异。我们将检查与临床最显着相关的血压变异之间的关联证据。与已建立的联盟合作研究相关的心血管疾病和肾脏结果。这项研究的结果可能对基因发现和基因座精细定位产生广泛影响，并可能提供有关种族/民族差异的遗传决定因素的信息，以指导高血压及其并发症的预防和治疗策略。