The Sylvester Cancer Center Support Grant

西尔维斯特癌症中心支持补助金

• 批准号: 10670832
• 负责人: Stephen D. Nimer
• 金额: $ 214.9万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-10 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10670832
• 关键词: Achievement; Address; Advanced Malignant Neoplasm; Affect; Argentina; Award; Basic Science; Behavioral Research; Bioinformatics; Biometry; Cancer Biology; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Control Research Program; Cancer Etiology; Cancer Patient; Caribbean region; Catchment Area; Clinical; Clinical Research; Clinical Sciences; Communities; Community Outreach; Competence; Comprehensive Cancer Center; County; Cultural Backgrounds; Cultural Diversity; Development; Diagnosis; Discipline; Disparate; Disparity; Education; Ensure; Environment; Environmental Risk Factor; Epigenetic Process; Ethnic Origin; Extramural Activities; Florida; Flow Cytometry; Fostering; Funding; Future; Grant; Growth; Health Professional; Heterogeneity; Home; Human; Individual; Intervention; Investments; Knowledge; Latin America; Leadership; Learning; Malignant Neoplasms; Mentored Clinical Scientist Development Program; Mission; National Cancer Institute; Oncology; Outcome; Patient Care; Patients; Peer Review; Persons; Play; Population Research; Population Sciences; Positioning Attribute; Prevention; Race; Research; Research Infrastructure; Research Personnel; Resource Sharing; Rewards; Role; Schools; Scientific Advances and Accomplishments; Scientist; Services; Source; Strategic Planning; Technology; Training; Training and Education; Translational Research; Translations; Tumor Biology; United States National Institutes of Health; Universities; anticancer research; bench to bedside; cancer genomics; cancer health disparity; cancer prevention; cancer risk; college; community based research; community center; community engagement; ethnic identity; ethnic minority; health equity; innovation; insight; interest; multidisciplinary; novel; novel strategies; outreach; post-doctoral training; pre-doctoral; programs; racial minority; recruit; research facility; socioeconomic diversity; socioeconomics

PROJECT SUMMARY: OVERALL The Sylvester Comprehensive Cancer Center (Sylvester) at the University of Miami seeks National Cancer Institute (NCI) designation to support its mission to reduce the human burden from cancer through research, education, prevention, and the delivery of quality patient care. Sylvester, the only academic Cancer Center located in South Florida, serves one of the most diverse catchment areas in the US. This four-county region (Broward, Miami-Dade, Monroe, and Palm Beach Counties), commonly known as South Florida, is home to more than six million residents and is characterized by substantial ethnic, cultural, racial, and socioeconomic diversity, reflected in the individuals treated by Sylvester and those affected by its outreach efforts. Led by Stephen D. Nimer, MD since 2012, Sylvester leadership has assembled a highly collaborative group of investigators that now includes 114 cancer scientists from three University Schools and Colleges. Sylvester’s research is organized into three Research Programs—Cancer Control, Cancer Epigenetics, and Tumor Biology. These programs are unified by crosscutting scientific themes and by Sylvester’s broader mission to address the cancer burden and disparities prevalent in its catchment area. Sylvester has invested heavily in these Research Programs and in four state-of-the-art shared resources that support Sylvester’s cancer researchers: the Biostatistics and Bioinformatics, Onco-Genomics, Flow Cytometry, and Behavioral and Community-Based Research Shared Resources. Sylvester has also invested heavily in its clinical research infrastructure, which has led to a dramatic increase in interventional treatment accruals (from 75 in 2011 to 509 in 2017), with more than 50% of the 4,568 patient accruals in 2017 representing racial/ethnic minorities. The University has made a substantial commitment to advancing Sylvester’s research capabilities since 2012, supporting the recruitment of 41 cancer researchers and doubling Cancer Center space. Sylvester has also expanded its pre- and post-doctoral training efforts across the clinical, basic, translational, and population sciences, which have been rewarded with five recently awarded NIH or NCI-funded T32 training grants, a U54 grant with a significant training component, and a Paul Calabresi K12 grant. Finally, Sylvester has invested roughly $5.7M in its Intramural Funding Program from 2014 to 2018, which has yielded $25.2M in peer-reviewed funding. Today, Sylvester has $38M in extramural research funding (including training grants), which includes $11M from the NCI; this represents a 12% and 64% increase, respectively, over the past year. These impressive achievements have created a culture and environment that enable Sylvester scientists to make valuable contributions to the understanding of cancer biology and the development of novel approaches to cancer prevention, diagnosis, and treatment.

项目摘要：总体 迈阿密大学西尔维斯特综合癌症中心（Sylvester）寻求国家癌症 研究所（NCI）设计，以支持其通过研究减少癌症烧伤的使命， 教育，预防和优质患者护理的提供。西尔维斯特（Sylvester），唯一的学术癌症中心 位于佛罗里达州南部，是美国最多样化的集水区之一。这个四县 （布劳沃德，迈阿密戴德，门罗和棕榈滩县），通常称为南佛罗里达州 超过600万居民，其特征是实质性的种族，文化，种族和社会经济 多样性反映在由西尔维斯特（Sylvester）治疗的个人和受到外展努力影响的个人中。 自2012年以来，由医学博士Stephen D. Nimer领导，Sylvester Leadersrive组成了一个高度合作的小组 现在包括来自三所大学和大学的114位癌症科学家的研究人员。西尔维斯特的 研究分为三个研究计划：癌症控制，癌症表观遗传学和肿瘤 生物学。这些计划是通过穿越科学主题和西尔维斯特更广泛的使命来统一的 解决癌症的癌症和集水区普遍存在的差异。西尔维斯特（Sylvester）投资了 这些研究计划以及四个最先进的共享资源支持西尔维斯特的癌症 研究人员：生物统计学和生物信息学，元组学，流式细胞术和行为和行为和 基于社区的研究共享资源。 西尔维斯特（Sylvester）还在其临床研究基础设施上投入了大量投资，这导致了急剧增长 介入治疗精度（从2011年的75到2017年的509个），其中4,568例患者中有50％以上 2017年代表种族/族裔少数民族的应计。该大学已经做出了实质性的承诺 自2012年以来，晋升Sylvester的研究能力，支持41位癌症研究人员的招聘 并加倍癌症中心空间。西尔维斯特（Sylvester）还扩大了博士后培训工作 在临床，基础，翻译和人群科学中，最近获得了五个 授予NIH或NCI资助的T32培训补助金，具有重要培训部分的U54赠款，Paul Calabresi K12 Grant。最后，西尔维斯特（Sylvester）从 2014年至2018年，已获得2520万美元的同行评审资金。今天，西尔维斯特（Sylvester）拥有3800万美元的壁外 研究资金（包括培训补助金），其中包括NCI的1100万美元；这代表12％， 在过去的一年中，分别增加了64％。 这些令人印象深刻的成就创造了一种文化和环境，使西尔维斯特科学家能够 为理解癌症生物学和新方法的发展做出宝贵的贡献 预防癌症，诊断和治疗。