Tai Chi and Fibromyalgia

太极拳和纤维肌痛

基本信息

批准号：
8690771
负责人：
CHENCHEN WANG
金额：
$ 68.35万
依托单位：
TUFTS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8690771
关键词：
Address Adverse effects Advocate Aerobic Aerobic Exercise Affect American Area Boston Cardiovascular system Chinese People Chronic Clinical Clinical Trials Clinical effectiveness Communities Diagnosis Disabled Persons Disease Dose Education Effectiveness Exercise Fatigue Fibromyalgia Frequencies Goals Health Healthcare Systems Impairment Individual Institute of Medicine (U.S.)Insurance Carriers Intervention Life Measures Medical Mental Health Mind-Body Intervention Muscle Musculoskeletal Pain Occupations Outcome Pain Pain Disorder Patients Perception Performance Personal Satisfaction Physical therapy exercises Policy Maker Population Quality of life Questionnaires Randomized Randomized Controlled Trials Regimen Research Rheumatology Schedule Self Efficacy Severities Sleep Sleep disturbances Stretching Symptoms Syndrome Tai Ji Testing Therapeutic Time United States Work blind body-mind chronic pain college combat comparative effectiveness conditioning cost disability payment disabling disease economic impact effective intervention effective therapy effectiveness research effectiveness trial flexibility follow-up group intervention health related quality of life improved innovation meetings metropolitan muscle strength novel physical conditioning primary outcome programs psychologic psychosocial satisfaction secondary outcome standard of care tool

项目摘要

DESCRIPTION (provided by applicant): Fibromyalgia (FM) is a chronic musculoskeletal pain syndrome that causes substantial physical and psychological impairment and costs over $25 billion annually. Current pharmacological therapies may be expensive, cause serious adverse effects, and fail to effectively improve pain and function. Thus, finding new and effective non-pharmacological treatments for FM patients is urgently needed. Previous research has demonstrated that Tai Chi, a traditional Chinese mind-body exercise, can improve both physical and mental health for FM patients. However, no clinical trials have demonstrated its clinical effectiveness compared to standard aerobic exercise therapy, or determined its optimum dose (frequency or duration) as a treatment for FM. We therefore propose to conduct the first comparative effectiveness trial of Tai Chi vs. aerobic exercise (a recommended component of the current standard of care) and to evaluate effectiveness under different Tai Chi dosing schedules in a large FM population. We aim to (1) demonstrate that, compared to aerobic exercise, Tai Chi is a more effective intervention for managing the pain and improving the functional limitations that impact quality of life for FM patients, and 2) determine the optimal frequency and duration of a supervised Tai Chi intervention in relation to short and long-term effectiveness. To achieve this goal, we will conduct a single-blind, randomized controlled trial of Tai Chi vs. aerobic exercise in 216 patients who meet the American College of Rheumatology criteria for FM. Patients will be randomized to one of four Tai Chi intervention groups: 12 or 24 weeks of supervised Tai Chi given once or twice per week, or a supervised aerobic exercise control (2x/week for 24 weeks). All groups will have a 52-week follow-up. The primary outcome will be the FM Impact Questionnaire total score at 24 weeks. Secondary outcomes include the measures of widespread pain, functional performance, psychological functioning, self-efficacy, sleep quality, and quality of life at 12, 24, and 52 weeks. Successful completion of the proposed study will determine the ideal regimen of Tai Chi and demonstrate that Tai Chi can be a simple, effective, and durable treatment for this therapeutically challenging disorder. We believe that our work will convince the clinical community to implement Tai Chi as a first-line treatment for the millions of individuals with FM.

描述（由申请人提供）：纤维肌痛 (FM) 是一种慢性肌肉骨骼疼痛综合征，会导致严重的身体和心理损伤，每年造成的费用超过 250 亿美元。目前的药物疗法可能价格昂贵，会造成严重的副作用，并且无法有效改善疼痛和功能。因此，迫切需要为 FM 患者寻找新的有效的非药物治疗方法。先前的研究表明，太极拳这种中国传统的身心锻炼可以改善FM患者的身心健康。然而，尚无临床试验证明其与标准有氧运动疗法相比的临床有效性，或确定其作为 FM 治疗的最佳剂量（频率或持续时间）。因此，我们建议对太极拳与有氧运动（当前护理标准的推荐组成部分）进行首次比较有效性试验，并评估在大量 FM 人群中不同太极拳给药方案的有效性。我们的目标是 (1) 证明，与有氧运动相比，太极拳是一种更有效的干预措施，可以控制疼痛和改善影响 FM 患者生活质量的功能限制，2) 确定最佳频率和持续时间监督太极拳干预的短期和长期效果。为了实现这一目标，我们将对 216 名符合美国风湿病学会 FM 标准的患者进行太极拳与有氧运动的单盲、随机对照试验。患者将被随机分配到四个太极拳干预组之一：每周一次或两次监督下的太极拳，为期 12 或 24 周，或监督下的有氧运动对照（每周 2 次，持续 24 周）。所有小组都将进行为期 52 周的随访。主要结果将是 24 周时的 FM 影响问卷总分。次要结局包括 12、24 和 52 周时广泛疼痛、功能表现、心理功能、自我效能、睡眠质量和生活质量的测量。成功完成拟议的研究将确定太极拳的理想疗法，并证明太极拳可以成为治疗这种具有治疗挑战性的疾病的简单、有效和持久的疗法。我们相信，我们的工作将说服临床界将太极拳作为数百万 FM 患者的一线治疗方法。