Memory fragmentation during threat-driven naturalistic events

威胁驱动的自然事件期间的内存碎片

• 批准号: 10670678
• 负责人: David Franklin Gregory
• 金额: $ 3.57万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-30 至 2024-06-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10670678
• 关键词: Amygdaloid structure; Animal Model; Animals; Arousal; Behavioral; Behavioral Paradigm; Binding; Cell Nucleus; Charge; Clip; Complex; Data; Development; Education; Emotional; Ensure; Environment; Episodic memory; Event; Experimental Designs; Fellowship; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Future; Goals; Heart Rate; Hippocampus; Homologous Gene; Hour; Human; Image; Imaging Techniques; Individual; Laboratories; Literature; Measures; Medial; Memory; Mentors; Methods; Modeling; Neurobiology; Physiological; Post-Traumatic Stress Disorders; Predisposition; Process; Productivity; Research; Research Design; Research Personnel; Retrieval; Role; Statistical Models; Stimulus; Structure; System; Techniques; Temporal Lobe; Testing; Time; Training; Translating; archived data; career; cognitive neuroscience; cohesion; design; experience; imaging study; information processing; insight; locus ceruleus structure; member; memory encoding; movie; neural; neurobehavioral; neuroimaging; neuromechanism; neurophysiology; neuroregulation; noradrenergic; novel; response; scaffold; skills; spatiotemporal; training opportunity

PROJECT SUMMARY/ABSTRACT Threat as a behavioral and neural construct impacts memory quality. Animal models show arousal-related dysfunction of the MTL, with homologs in the human neuroimaging literature. Specifically, high arousal biases memory encoding towards item-based processing at the detriment of contextual binding in the hippocampus, leading towards memory fragmentation. Research using naturalistic stimuli (i.e., movie clips) allows realistic portrayal to induce threat-driven episodic memory and subsequent impact of accurate arousal-induced dysfunction; however, the role of functional engagement of the MTL have not been wholly identified during the encoding and retrieval of arousal-driven events. The proposed study will utilize ecologically valid experimental designs of tasked-based imaging techniques during encoding and retrieval using naturalistic event memoranda and unconstrained free recall, to better model real-world contexts. This proposal will provide a neurobiological foundation to identify biases in memory due to threat-related arousal. Further, this project and fellowship would allow me to obtain key training opportunities, particularly in neuroimaging analysis, statistical modeling, and theoretical understanding of synthesizing the cognitive neuroscience of memory and neuromodulation; all of which I would not otherwise have the time to receive without this funding. My mentor, co-mentor and I have designed a training plan that will allow me to translate animal models into human neuroimaging research, and gain skills to apply these methods to provide frameworks to understand how threat-related arousal biases memory cohesion. Further, through these experiences I will master analysis techniques needed to characterize neurobehavioral correlates of task-based imaging study designs. These efforts will ensure I gain the professional, analytical, and theoretical skills necessary for my future career as an independent investigator in the domain of arousal-related memory. The support of this fellowship will allow me to round out my education and develop into a productive and impactful researcher, identifying neural mechanisms for threat-related arousal impacts on natural memory formation and memory fragmentation, which I will hope to apply to models of PTSD in the future.

项目概要/摘要 威胁作为一种行为和神经结构会影响记忆质量。动物模型显示与唤醒相关 MTL 功能障碍，与人类神经影像文献中的同源物。具体来说，高唤醒偏差 记忆编码朝向基于项目的处理，但会损害海马体的上下文绑定， 导致内存碎片。使用自然刺激（即电影剪辑）的研究可以实现现实 描绘以诱发威胁驱动的情景记忆以及准确唤醒诱发的后续影响 功能障碍；然而，MTL 的功能参与的作用在 觉醒驱动事件的编码和检索。拟议的研究将利用生态有效的实验 使用自然事件备忘录进行编码和检索期间基于任务的成像技术的设计 和不受限制的自由回忆，以更好地模拟现实世界的环境。该提案将提供神经生物学 识别由于威胁相关的唤醒而导致的记忆偏差的基础。此外，该项目和研究金将 让我获得重要的培训机会，特别是在神经影像分析、统计建模和 对综合记忆和神经调节的认知神经科学的理论理解；所有的 如果没有这笔资金，我就没有时间收到它。我和我的导师、共同导师 设计了一个培训计划，使我能够将动物模型转化为人类神经影像研究，并且 获得应用这些方法的技能，以提供框架来理解与威胁相关的唤醒偏差 记忆凝聚力。此外，通过这些经验，我将掌握表征所需的分析技术 基于任务的成像研究设计的神经行为相关性。这些努力将确保我获得 我未来作为独立调查员的职业生涯所必需的专业、分析和理论技能 与唤醒相关的记忆领域。这项奖学金的支持将使我能够完成我的学业 并发展成为一名富有成效和有影响力的研究人员，识别与威胁相关的神经机制 唤醒对自然记忆形成和记忆碎片的影响，我希望将其应用于模型 PTSD 的未来。