Memory fragmentation during threat-driven naturalistic events

威胁驱动的自然事件期间的内存碎片

• 批准号: 10670678
• 负责人: David Franklin Gregory
• 金额: $ 3.57万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-30 至 2024-06-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10670678
• 关键词: Amygdaloid structure; Animal Model; Animals; Arousal; Behavioral; Behavioral Paradigm; Binding; Cell Nucleus; Charge; Clip; Complex; Data; Development; Education; Emotional; Ensure; Environment; Episodic memory; Event; Experimental Designs; Fellowship; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Future; Goals; Heart Rate; Hippocampus; Homologous Gene; Hour; Human; Image; Imaging Techniques; Individual; Laboratories; Literature; Measures; Medial; Memory; Mentors; Methods; Modeling; Neurobiology; Physiological; Post-Traumatic Stress Disorders; Predisposition; Process; Productivity; Research; Research Design; Research Personnel; Retrieval; Role; Statistical Models; Stimulus; Structure; System; Techniques; Temporal Lobe; Testing; Time; Training; Translating; archived data; career; cognitive neuroscience; cohesion; design; experience; imaging study; information processing; insight; locus ceruleus structure; member; memory encoding; movie; neural; neurobehavioral; neuroimaging; neuromechanism; neurophysiology; neuroregulation; noradrenergic; novel; response; scaffold; skills; spatiotemporal; training opportunity

PROJECT SUMMARY/ABSTRACT Threat as a behavioral and neural construct impacts memory quality. Animal models show arousal-related dysfunction of the MTL, with homologs in the human neuroimaging literature. Specifically, high arousal biases memory encoding towards item-based processing at the detriment of contextual binding in the hippocampus, leading towards memory fragmentation. Research using naturalistic stimuli (i.e., movie clips) allows realistic portrayal to induce threat-driven episodic memory and subsequent impact of accurate arousal-induced dysfunction; however, the role of functional engagement of the MTL have not been wholly identified during the encoding and retrieval of arousal-driven events. The proposed study will utilize ecologically valid experimental designs of tasked-based imaging techniques during encoding and retrieval using naturalistic event memoranda and unconstrained free recall, to better model real-world contexts. This proposal will provide a neurobiological foundation to identify biases in memory due to threat-related arousal. Further, this project and fellowship would allow me to obtain key training opportunities, particularly in neuroimaging analysis, statistical modeling, and theoretical understanding of synthesizing the cognitive neuroscience of memory and neuromodulation; all of which I would not otherwise have the time to receive without this funding. My mentor, co-mentor and I have designed a training plan that will allow me to translate animal models into human neuroimaging research, and gain skills to apply these methods to provide frameworks to understand how threat-related arousal biases memory cohesion. Further, through these experiences I will master analysis techniques needed to characterize neurobehavioral correlates of task-based imaging study designs. These efforts will ensure I gain the professional, analytical, and theoretical skills necessary for my future career as an independent investigator in the domain of arousal-related memory. The support of this fellowship will allow me to round out my education and develop into a productive and impactful researcher, identifying neural mechanisms for threat-related arousal impacts on natural memory formation and memory fragmentation, which I will hope to apply to models of PTSD in the future.

项目摘要/摘要 作为行为和神经结构的威胁会影响记忆质量。动物模型显示与唤醒有关 MTL功能障碍，具有人类神经影像学文献中的同源物。具体而言，高唤醒偏见 在海马中的上下文绑定损害基于项目的处理的内存， 导致记忆破碎。使用自然主义刺激（即电影剪辑）的研究允许逼真 引起威胁驱动的情节记忆的刻画以及准确唤醒引起的后续影响 功能障碍；但是，MTL功能参与的作用尚未完全确定 编码和检索唤醒驱动的事件。拟议的研究将利用生态有效的实验 使用自然主义事件备忘录在编码和检索过程中基于任务的成像技术的设计 和不受限制的免费召回，以更好地模拟现实世界的上下文。该建议将提供神经生物学 由于威胁相关的唤醒而识别记忆中的偏见的基础。此外，这个项目和奖学金将 允许我获得关键的培训机会，尤其是在神经成像分析，统计建模和 理论理解记忆和神经调节的认知神经科学；所有人 如果没有这笔资金，我否则我将没有时间收到。我的导师，我和我有 设计了一个培训计划，使我能够将动物模型转化为人类神经影像学研究，并 提高技能以应用这些方法提供框架，以了解与威胁相关的唤醒偏见如何 记忆凝聚力。此外，通过这些经验，我将掌握分析技术来表征 基于任务成像研究设计的神经行为相关性。这些努力将确保我获得 我未来作为独立研究者的职业生涯所必需的专业，分析和理论技能 与唤醒相关的内存的域。这项奖学金的支持将使我能够完善我的教育 并发展成为一名富有成效且有影响力的研究人员，确定与威胁有关的神经机制 唤醒对自然记忆形成和记忆破碎的影响，我希望将其应用于模型 将来的PTSD。