Clinical Core

临床核心

基本信息

批准号：
10668237
负责人：
James McCallum Noble
金额：
$ 85.79万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10668237
关键词：
Address African American population Aging Alzheimer&apos s Disease Alzheimer&apos s Disease Pathway Alzheimer&apos s disease related dementia Area Autopsy Basic Science Biological Biological Markers Blood Blood Cells Blood specimen Brain Brain imaging Caregivers Cells Cerebrospinal Fluid Cessation of life Clinical Clinical Data Clinical Research Clinical Trials Code Collaborations DNA Data Data Collection Data Coordinating Center Data Element Data Set Database Management Systems Dementia Dementia with Lewy Bodies Diagnosis Diagnostic Disease Enrollment Ensure Environment Evaluation Extramural Activities Family Frontotemporal Dementia Funding Genetic Genetic study Goals Hispanic Populations Image Immunologics Impaired cognition Impairment Individual International Interview Liquid substance Magnetic Resonance Imaging Medical Neurologic Neuropsychological Tests Neuropsychology New York Participant Pathway interactions Patient Recruitments Peripheral Blood Mononuclear Cell Persons Pharmaceutical Preparations Plasma Population Preparation Quality Control Research Research Personnel Resource Sharing Resources Sampling Scientist Site Specific qualifier value Specimen Spinal Puncture Students Testing Time Tissues Training Translational Research biomarker panel brain tissue clinical center cohort data cleaning data exchange data management data standards demented ethnic diversity improved instrument mild cognitive impairment multi-ethnic neuroimaging neuroimmunology neuropathology outreach participant enrollment patient engagement randomized, clinical trials recruit repository skills social symposium training opportunity transmission process

Address African American population Aging Alzheimer&apos s Disease Alzheimer&apos s Disease Pathway Alzheimer&apos s disease related dementia Area Autopsy Basic Science Biological Biological Markers Blood Blood Cells Blood specimen Brain Brain imaging Caregivers Cells Cerebrospinal Fluid Cessation of life Clinical Clinical Data Clinical Research Clinical Trials Code Collaborations DNA Data Data Collection Data Coordinating Center Data Element Data Set Database Management Systems Dementia Dementia with Lewy Bodies Diagnosis Diagnostic Disease Enrollment Ensure Environment Evaluation Extramural Activities Family Frontotemporal Dementia Funding Genetic Genetic study Goals Hispanic Populations Image Immunologics Impaired cognition Impairment Individual International Interview Liquid substance Magnetic Resonance Imaging Medical Neurologic Neuropsychological Tests Neuropsychology New York Participant Pathway interactions Patient Recruitments Peripheral Blood Mononuclear Cell Persons Pharmaceutical Preparations Plasma Population Preparation Quality Control Research Research Personnel Resource Sharing Resources Sampling Scientist Site Specific qualifier value Specimen Spinal Puncture Students Testing Time Tissues Training Translational Research biomarker panel brain tissue clinical center cohort data cleaning data exchange data management data standards demented ethnic diversity improved instrument mild cognitive impairment multi-ethnic neuroimaging neuroimmunology neuropathology outreach participant enrollment patient engagement randomized, clinical trials recruit repository skills social symposium training opportunity transmission process

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项目摘要

CLINICAL CORE PROJECT SUMMARY/ABSTRACT The Clinical Core is the central component of the P30 Alzheimer’s Disease Research Center (ADRC). The Clinical Core mandate is to provide resources to further the goals of the Center in understanding biological pathways of Alzheimer’s Disease. The Core is a shared resource interacting closely with: the Outreach, Recruitment, and Engagement Core (ORE) Core with regard to recruitment and training; the Database Management and Statistical (DMS) Core with respect to data entry, storage and management; the Neuropathology Core, through arranging brain autopsy and providing relevant correlative clinical data; and the Biomarker, Genetics, and Neuroimmunology Cores through provision of DNA, plasma, blood cells, and cerebrospinal fluid samples for biomarker, genetic, and immunological analyses. The Core will build upon its 29 years as a funded P50 ADRC, during which time it has enrolled more than 6,000 individuals, nearly 1,900 of which are in the NACC Uniform Data Set (UDS) – with ethnic diversity including about 20% Hispanics and 11% African Americans. The P30 Core will enroll 500 individuals in a new cohort: 100 new participants per year, including 25 normal controls, and 75 persons with mild cognitive impairment or dementia. These participants will each have extensive biomarker studies including research-grade 3T MRI, and lumbar puncture for cerebrospinal fluid studies, and be followed annually. The Core will provide data to the DMS Core, transmitted to the National Alzheimer’s Coordinating Center (NACC), and DNA for the Genetics Core, sent to the National Centralized Repository for Alzheimer’s Disease (NCRAD). Evaluations will include detailed medical and neurological interviews and examinations and neuropsychological testing, using NACC and Columbia site- specific instruments. Biomarkers will flow to Biomarker, Genetics, and Neuroimmunology Cores, including blood samples for plasma and peripheral blood cell populations, DNA preparation for genetic studies, CSF specimens for spinal fluid cells and fluid biomarkers, and 3T MRI neuroimaging. The Clinical Core goals include brain autopsies at the time of death, to provide neuropathological samples. The Core coordinates closely with Administrative, Biomarkers, DMS, ORE, Genetics, Neuroimmunology, and Neuropathology Cores, and with the REC module. Participants in the Core are informed of other trials and projects, and encouraged to participate in these important imaging, instrument, drug study, and biomarker trials. The Clinical Core provides training to students, residents, fellows, and investigators. Coded participant data, images, and biological specimens, including plasma, DNA, CSF, and brain tissue are shared with ADRC, and other Columbia and extramural investigators to improve diagnosis, understanding and treatment of aging and dementia, promoting basic and translational research at Columbia, in the New York area, nationwide, and internationally.

临床核心项目摘要/摘要临床核心是P30阿尔茨海默氏病研究中心（ADRC）的核心组成部分。这临床核心任务是提供资源以进一步了解中心的目标以理解生物学阿尔茨海默氏病的途径。核心是一种共享资源，与：外展，外展，在招聘和培训方面，招聘和参与核心（矿石）核心；数据库在数据输入，存储和管理方面，管理和统计（DMS）核心；这神经病理学核心，通过安排脑尸检并提供相关的相关临床数据；和生物标志物，遗传学和神经免疫学通过提供DNA，血浆，血细胞和用于生物标志物，遗传和免疫学分析的脑脊液样品。核心将建立在其基础上 29年作为资助的P50 ADRC，在此期间，它已经招募了6,000多名个人，近1,900人在NACC统一数据集（UDS）中，种族多样性包括约20％的西班牙裔和11％非裔美国人。 P30核心将招募500个人参加新队列：每年100名新参与者，包括25个正常对照，有75人患有轻度认知障碍或痴呆症。这些参与者每个人都将进行广泛的生物标志物研究，包括研究级3T MRI和腰椎穿刺脑脊液研究，每年遵循。核心将向DMS核心提供数据，并传输到达国家遗传学核心的国家阿尔茨海默氏症协调中心（NACC）和DNA发送给国家阿尔茨海默氏病（NCRAD）的集中存储库。评估将包括详细的医学和使用NACC和哥伦比亚地点 - 特定仪器。生物标志物将流向生物标志物，遗传学和神经免疫学核心，包括血浆和外周血细胞种群的血液样本，遗传研究的DNA制备，CSF 脊柱流体细胞和流体生物标志物的标本以及3T MRI神经影像学。临床核心目标在死亡时包括大脑尸检，以提供神经病理学样本。核心坐标与行政，生物标志物，DMS，矿石，遗传学，神经免疫学和神经病理学核心紧密相关，并带有REC模块。核心的参与者会了解其他试验和项目，并鼓励参加这些重要的成像，仪器，药物研究和生物标志物试验。临床核心提供对学生，居民，研究员和调查人员进行培训。编码的参与者数据，图像和生物学包括等离子体，DNA，CSF和脑组织在内的标本与ADRC和其他哥伦比亚共享外壁外研究人员改善诊断，了解和治疗衰老和痴呆症，促进基础和翻译的研究在哥伦比亚，纽约地区，全国和国际上。